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Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function

  • Benign Prostatic Hyperplasia (K McVary, Section Editor)
  • Published:
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Abstract

Medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia are frequently associated with changes in sexual function. While these medications are generally well-tolerated and have both reduced and delayed more invasive surgical options, the ramifications of long-term chronic use are largely unknown. Sexual side effects of these medications are frequently either reported as part of a short-term initial drug study or have inflexible endpoints that are not able to gauge more subtle changes in sexual performance. This review will delineate the currently known effects of these medications on sexual function and will consider mechanisms of dysfunction.

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Conflict of Interest

Dr. R. Charles Welliver Jr. reports other financial or material support from American Medical Systems, Coloplast, and Sophiris.

Dr. Michael Butcher and Dr. Yogitha Potini each declare no potential conflict of interest.

Dr. Kevin T. McVary reports personal fees from Allergan, Lilly/ICOS, Watson Pharmaceuticals, NeoTract, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Sophiris, outside the submitted work. In addition, Dr. McVary has patents pending for 1) Thermal-Activated Penile Prosthesis Using a Shape-Memory Biomaterial. Dr. McVary is a section editor for Current Urology Reports.

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  1. Albany Medical College, Albany, NY, 12208, USA

    Charles Welliver

  2. Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, 62794, USA

    Michael Butcher, Yogitha Potini & Kevin T. McVary

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  1. Charles Welliver
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  2. Michael Butcher
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Correspondence to Charles Welliver.

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This article is part of the Topical Collection on Benign Prostatic Hyperplasia

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Welliver, C., Butcher, M., Potini, Y. et al. Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function. Curr Urol Rep 15, 441 (2014). https://doi.org/10.1007/s11934-014-0441-2

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