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Surgical Techniques and Pitfalls for Excision and Grafting

  • Male and Female Surgical Interventions (C Carson and M Khera, Section Editors)
  • Published:
Current Sexual Health Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To highlight the surgical techniques of Peyronie plaque excision with grafting technique. We also sought to help the surgeon with important aspects of pre-operative and post-operative counseling.

Recent Findings

The pre-operative discussion is imperative in setting expectations and goals of care. The ideal graft has yet to be developed, but improvements have been made with decreased risks of infection and contracture rates.

Summary

We have learned that Peyronie’s disease is still a surgically treatable disease. Excision and grafting is a complex procedure, but with an appropriate technique, complex curvatures can be managed in trained hands. Patient selection is imperative in deciding whether concomitant penile prosthesis should be placed. Graft choice is left up to the operating surgeon, but use of non-autologous grafts appears to be increasing.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. El-Sakka AI, et al. Peyronie’s disease is associated with an increase in transforming growth factor-beta protein expression. J Urol. 1997;158:1391–4.

    Article  CAS  Google Scholar 

  2. Dolmans GH, Werker PM, de Jong IJ, Nijman RJ, Wijmenga C, Ophoff RA. WNT2 locus is involved in genetic susceptibility of Peyronie’s disease. J Sex Med. 2012;9(5):1430–4.

    Article  CAS  Google Scholar 

  3. Dibenedetti DB, Nguyen D, Zografos L, Ziemiecki R, Zhou X. A population-based study of Peyronie’s disease: prevalence and treatment patterns in the United States. Adv Urol. 2011;2011:282503.

    Article  Google Scholar 

  4. Tefekli A, Kandirali E, Erol B, Tunc M. A.Kadioglu Peyronie’s disease: a silent consequence of diabetes mellitus. Asian J Androl. 2006;8(1):75–9.

    Article  CAS  Google Scholar 

  5. Pryor JP, Ralph DJ. Clinical presentations of Peyronie’s disease. Int J Impot Res. 2002;14(5):414–7.

    Article  CAS  Google Scholar 

  6. Gelbard MK, Dorey F, James K. The natural history of Peyronie’s disease. J Urol. 1990;144:1376.

    Article  CAS  Google Scholar 

  7. Mulhall JP, Schiff J, Guhring P. An analysis of the natural history of Peyronie’s disease. J Urol. 2006;175:2115.

    Article  Google Scholar 

  8. Ralph D, Gonzalez-Cadavid N, Mirone V, et al. The management of Peyronie’s disease: evidence-based 2010 guidelines. J Sex Med. 2010;7:2359–74.

    Article  Google Scholar 

  9. Paulis G, Barletta D, Turchi P, et al. Efficacy and safety evaluation of pentoxifylline associated with other antioxidants in medical treatment of Peyronie’s disease: a case-control study. Res Rep Urol. 2015;8:1–10.

    PubMed  PubMed Central  Google Scholar 

  10. Chung E, Deyoung L, Brock GB. The role of PDE5 inhibitors in penile septal scar remodeling: assessment of clinical and radiological outcomes. J Sex Med. 2011;8:1472–7.

    Article  CAS  Google Scholar 

  11. Gelbard M, Goldstein I, Hellstrom WJ, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of Peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190:1199.

    Article  Google Scholar 

  12. Levine LA. Newell M andTaylor FL: Penile traction therapy for treatment of Peyronie’s disease: a single- center pilot study. J Sex Med. 2008;5:61468.

    Google Scholar 

  13. Raheem AA, Garaffa G, Raheem TA, et al. The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease. BJU Int. 2010;106:1178.

    Article  Google Scholar 

  14. Ziegelmann M, Savage J, Alom M, et al. LBA8 preliminary outcomes of a novel penile traction device (restorex) in men with Peyronie’s disease: a randomized, controlled trial. J Urol. 2018;199:e746.

    Google Scholar 

  15. • Levine LA, Burnett AL. Standard operating procedures for Peyronie’s disease. J Sex Med. 2013;10:1:230–44. Good outline for workup and management of patients with Peyronie disease.

  16. Staerman F, Pierrevelcin J, Ripert T, et al. Medium-term follow-up of plaque incision and porcine small intestinal submucosal grafting for Peyronie’s disease. Int J Impot Res. 2010;22:343–8.

    Article  CAS  Google Scholar 

  17. Wolf JS, Benett CJ, Dmochowski RR, et al. Best Practice Policy Statement on Urologic Surgery Antimicrobial Prophylaxis. Available online: http://www.auanet.org/guidelines/antimicrobial-prophylaxis-(2008-reviewed-and-validity-confirmed-2011-amended-2012)

  18. Austoni E, Altieri VM, Tenaglia R. Trans-scrotal penile degloving, a new procedure for corporoplasties. Urologia. 2012;79:200–10.

    Article  Google Scholar 

  19. Lue K, Emtage JB, Martinez DR, Yang C, Carrion R. Excision and patch grafting of a lateral Peyronie’s plaque-utilizing a longitudinal “window” approach. Sex Med. 2015;3(2):86–9.

    Article  Google Scholar 

  20. Kadioglu A, Tefekli A, Erol B, et al. A retrospective review of 307 men with Peyronie’s disease. J Urol. 2002;168:1075.

    Article  Google Scholar 

  21. Hatzichristodoulou G, Dorstewitz A, Gschwend JE, et al. Surgical management of penile fracture and long-term outcome on erectile function and voiding. J Sex Med. 2013;10:1424–30.

    Article  Google Scholar 

  22. Gelbard MK. Relaxing incisions in the correction of penile deformity due to Peyronie’s disease. J Urol. 1995;154:1457–60.

    Article  CAS  Google Scholar 

  23. Carson CC. Chun, JL Peyronie’s disease: surgical management: autologous materials. J Sex Med. 2002;14(5):329–35.

    CAS  Google Scholar 

  24. Salem E. Elkady et al. Lingual mucosal graft treatment of Peyronie’s disease. Urology. 2014;84(6):1374–7.

    Article  Google Scholar 

  25. Knoll LD, Furlow WL, Benson RC, Bilhartz DL. Comparison of the use of downsized infalatable penile prosthesis vs. prosthetic implantation with Gore-Tex grafting for non-dilatable cavernosal fibrosis. J Urol. 1993;149:A.

    Google Scholar 

  26. Jordan GH, Alter GJ, Gilbert DA, Horton CE, Devine CJ. Penile prosthesis implantation in total phalloplasty. J Urol. 1994;152:410–4.

    Article  CAS  Google Scholar 

  27. Hellstrom WJ, Reddy S. Application of pericardial graft in the surgical management of Peyronie’s disease. J Urol. 2000;163:1445–7.

    Article  CAS  Google Scholar 

  28. Knoll LD. Use of small intestinal submucosa graft for the surgical management of Peyronie’s disease. J Urol. 2007;178:2474–8.

    Article  Google Scholar 

  29. John T, Bandi G, Santucci R. Porcine small intestinal submucosa is not an ideal graft material for Peyronie’s disease surgery. J Urol. 2006;176:1025–8.

    Article  CAS  Google Scholar 

  30. Lee EW, Shindel AW, Brandes SB. Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie’s disease. Int Braz J Urol. 2008;34:191–6.

    Article  Google Scholar 

  31. Hafez A, El-Assmy AT, El-Hamid MA. 4 layer versus 1 layer small intestinal submucosa for correction of penile chordee: experimental study in a rabbit model. J Urol. 2004;171:2489–91.

    Article  Google Scholar 

  32. • Hatzichristodoulou G, Gschwend JE, Lahme S. Surgical therapy of Peyronie’s disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. Int J Impot Res. 2013;25:183–7. Describes a technique that has been adopted to minimize post-operative erectile dysfunction and highlights use of collagen fleece.

  33. • Falcone M, Preto M, Ceruti C, et al. A comparative study between 2 different grafts used as patches after plaque incision and inflatable penile prosthesis implantation for end-stage Peyronie’s disease. J Sex Med. 2018;15(6):848–52. https://doi.org/10.1016/j.jsxm.2018.04.632. Good review of graft materials and highlights use of xenografts and collagen fleece.

  34. Levine LA, Greenfield JM, Estrada CR. Erectile dysfunction following surgical correction of Peyronie’s disease and a pilot study of the use of sildenafil citrate rehabilitation for postoperative erectile dysfunction. J Sex Med. 2007;5:241–7.

    Google Scholar 

  35. Levine LA, Rybak J. A comparative analysis of traction therapy vs. no traction following tunica albuginea plication or partial excision and grafting for Peyronie’s disease: Measured lengths and patient perceptions. 2011 Annual Meeting of the American Urological Association.

  36. Chung E, Clendinning E, Lessard L, et al. Five-year follow-up of Peyronie’s graft surgery: outcomes and patient satisfaction. J Sex Med. 2011;8:594–600.

    Article  Google Scholar 

  37. Sansalone S, Garaffa G, Djinovic R, et al. Long-term results of the surgical treatment of Peyronie’s disease with Egydio’s technique: a European multicentre study. Asian J Androl. 2011;13:842–5.

    Article  Google Scholar 

  38. Taylor FL, Levine LA. Surgical correction of Peyronie’s disease via tunica albuginea plication or partial plaque excision with pericardial graft: long-term follow up. J Sex Med. 2008;5:2221–8.

    Article  Google Scholar 

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Correspondence to Lorenzo DiGiorgio.

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Conflict of Interest

Rafael Carrion reports serving as a consultant for Coloplast and Endo, outside of submitted work.

Justin Parker reports serving as a consultant for Coloplast, and a Speaker for Baxter, outside of submitted work.

Lorenzo DiGiorgio and Melissa Mendez each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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DiGiorgio, L., Mendez, M., Parker, J. et al. Surgical Techniques and Pitfalls for Excision and Grafting. Curr Sex Health Rep 11, 406–410 (2019). https://doi.org/10.1007/s11930-019-00207-w

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  • DOI: https://doi.org/10.1007/s11930-019-00207-w

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