Skip to main content

Advertisement

Log in

Depression Treatment Expenditures for Adults in the USA: a Systematic Review

  • Mood Disorders (E Baca-Garcia, Section Editor)
  • Published:
Current Psychiatry Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

We review 2016–2019 peer-reviewed literature which summarizes the factors contributing to high expense of treating depression among adults in the USA, and interventions that have been conducted to decrease depression treatment expenditures.

Recent Findings

Treatment expenditures associated with depression are high and growing, driven in part by increased health care utilization and a shift toward increased insurance coverage of medications and therapies. The majority of identified articles describe the elevated financial burden associated with treating individuals with chronic medical conditions who also have a depression diagnosis. The few available studies documenting health care system-level interventions identify that multi-target treatment for comorbid illness, collaborative care management, and integration of psychiatric treatment into primary care show promise for reducing depression treatment expenditures.

Summary

Additional research is needed to identify innovative, cost-effective state, and federal payer-initiated depression treatment models, and evaluation of collaborative care and integrated care models implemented to scale across multiple health care systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). Washington, D.C: American Psychiatric Pub; 2013.

    Book  Google Scholar 

  2. Allen J, Balfour R, Bell R, Marmot M. Social determinants of mental health. Int Rev Psychiatry. 2014;26(4):392–407.

    Article  Google Scholar 

  3. Kohout FJ, Berkman LF, Evans DA, Cornoni-Huntley J. Two shorter forms of the CES-D depression symptoms index. J Aging Health. 1993;5(2):179–93.

    Article  CAS  Google Scholar 

  4. Greenberg PE, Fournier AA, Sisitsky T, Pike CT, Kessler RC. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry. 2015;76(2):155–62.

    Google Scholar 

  5. Kessler RC. The costs of depression. Psychiatr Clin N Am. 2012;35(1):1–14.

    Article  Google Scholar 

  6. Hasin DS, Sarvet AL, Meyers JL, Saha TD, Ruan WJ, Stohl M, et al. Epidemiology of adult dsm-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry. 2018;75(4):336–46.

    Article  Google Scholar 

  7. Egede LE, Bishu KG, Walker RJ, Dismuke CE. Impact of diagnosed depression on healthcare costs in adults with and without diabetes: United States, 2004-2011. J Affect Disord. 2016;195:119–26.

    Article  Google Scholar 

  8. Dieleman JL, Baral R, Birger M, Bui AL, Bulchis A, Chapin A, et al. US spending on personal health care and public health, 1996-2013. JAMA. 2016;316(24):2627–46.

    Article  Google Scholar 

  9. Beiser DG. et al., Depression in emergency department patients and association with health care utilization. Acad Emerg Med. 2019;0(0).

  10. Dennehy EB, Robinson RL, Stephenson JJ, Faries D, Grabner M, Palli SR, et al. Impact of non-remission of depression on costs and resource utilization: from the COmorbidities and symptoms of DEpression (CODE) study. Curr Med Res Opin. 2015;31(6):1165–77.

    Article  Google Scholar 

  11. Himelhoch S, Weller WE, Wu AW, Anderson GF, Cooper LA. Chronic medical illness, depression, and use of acute medical services among Medicare beneficiaries. Med Care. 2004;42(6):512–21.

    Article  Google Scholar 

  12. Robinson RL, Grabner M, Palli SR, Faries D, Stephenson JJ. Covariates of depression and high utilizers of healthcare: impact on resource use and costs. J Psychosom Res. 2016;85:35–43.

    Article  Google Scholar 

  13. Yoon J, M. Yano E, Altman L, Cordasco KM, E. Stockdale S, Chow A, et al. Reducing costs of acute care for ambulatory care-sensitive medical conditions: the central roles of comorbid mental illness. Med Care. 2012;50(8):705–13.

    Article  Google Scholar 

  14. Croghan TW, Obenchain RL, Crown WE. What does treatment of depression really cost? Health Aff. 1998;17(4):198–208.

    Article  CAS  Google Scholar 

  15. Sullivan M, Simon G, Spertus J, Russo J. Depression-related costs in heart failure care. Arch Intern Med. 2002;162(16):1860–6.

    Article  Google Scholar 

  16. Birnbaum HG, Kessler RC, Kelley D, Ben-Hamadi R, Joish VN, Greenberg PE. Employer burden of mild, moderate, and severe major depressive disorder: mental health services utilization and costs, and work performance. Depress Anxiety. 2010;27(1):78–89.

    Article  Google Scholar 

  17. Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.

    Article  Google Scholar 

  18. • Ammerman RT, et al. Annual direct health care expenditures and employee absenteeism costs in high-risk, low-income mothers with major depression. J Affect Disord. 2016;190:386–94. This article reviews the high costs associated with depression treatment among high-risk, low-income mothers facing social adversity. Using a longitudinal, large, and nationally representative sample, this is the sole study in the current review highlighting the impact of social determinants of health on treatment outcomes and expenditures.

    Article  Google Scholar 

  19. Ammerman RT, Mallow PJ, Rizzo JA, Putnam FW, van Ginkel JB. Cost-effectiveness of in-home cognitive behavioral therapy for low-income depressed mothers participating in early childhood prevention programs. J Affect Disord. 2017;208:475–82.

    Article  Google Scholar 

  20. Bilal J, et al. The influence of depression on health care expenditures among adults with spondylosis, intervertebral disc disorders, and other Back problems in the United States. Pain Med. 2018;0(0):1–9.

    Google Scholar 

  21. Click B, Ramos Rivers C, Koutroubakis IE, Babichenko D, Anderson AM, Hashash JG, et al. Demographic and clinical predictors of high healthcare use in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2016;22(6):1442–9.

    Article  Google Scholar 

  22. Courtney PM, Bohl DD, Lau EC, Ong KL, Jacobs JJ & Della Valle CJ. Risk adjustment is necessary in Medicare bundled payment models for total hip and knee arthroplasty. J. Arthroplast. 2018;33(8):2368–2375. https://doi.org/10.1016/j.arth.2018.02.095.

    Article  Google Scholar 

  23. Deb A, et al. Burden of depression among working-age adults with rheumatoid arthritis. Arthritis. 2018;2018:1–11.

    Article  Google Scholar 

  24. Domino ME, Kilany M, Wells R, Morrissey JP. Through the looking glass: estimating effects of medical homes for people with severe mental illness. Health Serv Res. 2017;52(5):1858–80.

    Article  Google Scholar 

  25. Egede LE, Walker RJ, Bishu K, Dismuke CE. Trends in costs of depression in adults with diabetes in the United States: medical expenditure panel survey, 2004-2011. J Gen Intern Med. 2016;31(6):615–22.

    Article  Google Scholar 

  26. Gangan N & Yang Y. The impact of work absences on health services utilization and costs among employed individuals with depression. J. Occup. Environ. Med. 2018;60(3):e139–e145. https://doi.org/10.1097/jom.0000000000001259.

    Article  Google Scholar 

  27. •• Hockenberry JM, et al. Trends in treatment and spending for patients receiving outpatient treatment of depression in the United States, 1998–2015. JAMA Psychiatry. 2019;Online:E1–8. This review of national trends in outpatient depression treatment and associated costs documents significant shifts in expenditures from 1998 to 2007, then again from 2007 to 2015 due to changes in health policy.

    Google Scholar 

  28. Johnston KJ, et al. Association between patient cognitive and functional status and Medicare Total annual cost of care: implications for value-based PaymentAssociation between patient cognitive and functional status and Medicare cost of CareAssociation between patient cognitive and functional status and Medicare cost of care. JAMA Intern Med. 2018;178(11):1489–97.

    Article  Google Scholar 

  29. • Moise N, et al. Sustainability of collaborative care management for depression in primary care settings with academic affiliations across New York State. Implement Sci : IS. 2018;13(1):128–128. This New York State study reviews barriers and facilitators affecting whether 32 primary care clinics sustain a care management model for outpatient depression treatment.

    Article  Google Scholar 

  30. Ogunsanya ME, Nduaguba SO, Brown CM. Incremental health care services and expenditures associated with depression among individuals with cutaneous lupus erythematosus (CLE). Lupus. 2018;27(7):1107–15.

    Article  CAS  Google Scholar 

  31. Park C, Fang J, Hawkins NA, Wang G. Comorbidity status and annual total medical expenditures in U.S. hypertensive adults. Am J Prev Med. 2017;53(6, Supplement 2):S172–81.

    Article  Google Scholar 

  32. Penna S, Bell KL, Kuo FC, Henderson RA, Foltz C & Chen AF. Impact of co-morbidities on the cost of care in primary elective joint arthroplasty. J. Arthroplast. 2019;34(5):834–838. https://doi.org/10.1016/j.arth.2019.01.038.

    Article  Google Scholar 

  33. Shao H, Mohammed MU, Thomas N, Babazadeh S, Yang S, Shi Q, et al. Evaluating excessive burden of depression on health status and health care utilization among patients with hypertension in a nationally representative sample from the Medial Expenditure Panel Survey (MEPS 2012). J Nerv Ment Dis. 2017;205(5):397–404.

    Article  Google Scholar 

  34. •• Thorpe K, Jain S, Joski P. Prevalence and spending associated with patients who have a behavioral health disorder and other conditions. Health Affairs. 2017;36(1):124–32. This review examines factors contributing to the high costs associated with comorbid medical and psychiatric illness and demonstrates a need for evidence-based, whole person-oriented collaborative models of care.

    Article  Google Scholar 

  35. Wallace K, Zhao X, Misra R, Sambamoorthi U. The humanistic and economic burden associated with anxiety and depression among adults with comorbid diabetes and hypertension. Journal of diabetes research. 2018;2018:1–9.

    Article  Google Scholar 

  36. Wu J, Davis‐Ajami ML & Kevin Lu Z. Impact of depression on health and medical care utilization and expenses in US adults with migraine: a retrospective cross sectional study. Headache: The Journal of Head and Face Pain. 2017;56(7):1147–1160. https://doi.org/10.1111/head.12871.

    Article  Google Scholar 

  37. Gangan, N. and Y. Yang, The impact of work absences on health services utilization and costs among employed individuals with depression. 2018. 60(3): p. e139-e145.

  38. Barrett B, Byford S, Knapp M. Evidence of cost-effective treatments for depression: a systematic review. J Affect Disord. 2005;84(1):1–13.

    Article  Google Scholar 

  39. Gaisin I, Ivanova L. FRI0239 decreased prevalence of anxiety and depression in rheumatoid arthritis patients following b cell-targeted biologic therapy. Ann Rheum Dis. 2013;72(Suppl 3):A454-A454.

    Google Scholar 

  40. Centers for Disease Control and Prevention. Current depression among adults---United States, 2006 and 2008. MMWR. Morb Mortal Wkly Rep. 2010;59(38):1229.

    Google Scholar 

  41. Unutzer J, et al. The collaborative care model: an approach for integrating physical and mental health care in medicaid health homes, in health home: Information Resource Center. Baltimore: Centers for Medicare & Medicaid Services; 2013.

    Google Scholar 

  42. Chung H, et al. Advancing integration of behavioral health into primary care: A continuum-based framework. New York: United Hospital Fund; 2016.

    Google Scholar 

  43. Shim R, Rust G. Primary care, behavioral health, and public health: partners in reducing mental health stigma (editorial). Am J Prev Med. 2013;(May 2013).

  44. Berwick D, Nolan T, Whittington J. The triple aim: care, health, And Cost. Health Aff. 2008;27(1).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aaron Samuel Breslow.

Ethics declarations

Conflict of Interest

Aaron Samuel Breslow, Nathaniel M. Tran, Frederick Q. Lu, and Benjamin Lê Cook declare that they have no conflicts of interest.

Jonathan Alpert is a consultant for GLG consulting; grant funding from Otsuka Pharmaceuticals, Axome Therapeutics, and the Patient Centered Research Outcomes Institute (PCORI); payment for manuscript from Belvior Publications through Editorial Fees; and is the Chair of American Psychiatric Association Council on Research.

Human and Animal Rights

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Mood Disorders

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Breslow, A.S., Tran, N.M., Lu, F.Q. et al. Depression Treatment Expenditures for Adults in the USA: a Systematic Review. Curr Psychiatry Rep 21, 105 (2019). https://doi.org/10.1007/s11920-019-1083-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11920-019-1083-3

Keywords

Navigation