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The Role of Cortisol in First Episode of Psychosis: A Systematic Review

  • Schizophrenia and Other Psychotic Disorders (SJ Siegel, Section Editor)
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Abstract

The stress diathesis hypothesis is currently one of the prevailing models of etiology of psychotic disorders. Cortisol is the most researched stress hormone; yet its role in first episode psychosis (FEP) was only recently investigated. The aim of the present study is to systematically review the evidence on the potential role of cortisol in FEP. Higher cortisol levels in blood samples have been consistently replicated, whereas saliva studies measuring baseline cortisol levels have exhibited divergent results. Moreover, longitudinal studies have revealed a cortisol upregulation in FEP with a subsequent decrease induced by antipsychotic treatment. The evidence suggests a role for cortisol in psychosis, although the association of cortisol with psychopathological symptoms is currently non-specific. Future research should focus on more pure diagnostic entities, clearly defined stages of the disorder and refined methods of hormonal measurement.

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Evangelos Karanikas, Diomidis Antoniadis, and George D. Garyfallos declare that they have no conflict of interest.

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Authors and Affiliations

  1. 2nd Psychiatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Evangelos Karanikas, Diomidis Antoniadis & George D. Garyfallos

  2. 18 Pileas Street, Kato Toumba, Thessaloniki, 54454, Greece

    Diomidis Antoniadis

  3. 45Α Karakasi Street, 54248, Thessaloniki, Greece

    Evangelos Karanikas

  4. Psychiatric Hospital of Thessaloniki, Aristotle University of Thessaloniki, Lagada Ave 196, Stavroupolis, 56429, Thessaloniki, Greece

    George D. Garyfallos

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  1. Evangelos Karanikas
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Correspondence to Diomidis Antoniadis.

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Karanikas, E., Antoniadis, D. & Garyfallos, G.D. The Role of Cortisol in First Episode of Psychosis: A Systematic Review. Curr Psychiatry Rep 16, 503 (2014). https://doi.org/10.1007/s11920-014-0503-7

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