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Neuraxial Anesthesia and Analgesia During Cardiothoracic Surgery: A Narrative Review

  • New and Emerging Therapies in Interventional Pain Medicine (J Hasoon, Section Editor)
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Abstract

Purpose of Review

The purpose of this review is to synthesize and examine the literature on the use of neuraxial anesthesia and analgesia during cardiothoracic surgery. As cardiothoracic procedures often require systemic anticoagulation, neuraxial techniques are quite often underutilized due to the theoretical risk of epidural hematoma. In this review, we seek to examine the literature to review the indications and contraindications and to explore if neuraxial anesthesia and analgesia has a role in cardiothoracic surgery.

Recent Findings

Neuraxial techniques have multiple advantages during cardiothoracic surgery including coronary vasodilation, decreased sympathetic surge, and a decreased cortisol level leading to overall reduction in stress response. Multiple studies have shown an improvement in pain scores, reduction in pulmonary complications, faster extubation times, with minimal complications when neuraxial techniques are utilized in cardiothoracic surgeries.

Summary

Given the numerous advantages and minimal complications of neuraxial techniques in cardiothoracic surgeries, we hope its utilization continues to increase. Moving forward, we hope additional studies continue to reaffirm the benefits of neuraxial anesthesia and analgesia for cardiothoracic surgeries to improve its utilization.

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Data Availability

No datasets were generated or analysed during the current study.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Abrams BA, Weitzel NS. Neuraxial analgesia for cardiac surgery [Internet]. 2018 [cited 2023 Aug 12]. Available from: https://www.asra.com/news-publications/asra-newsletter/newsletter-item/asra-news/2018/07/18/neuraxial-analgesia-for-cardiac-surgery.

  2. Zhang S, Wu X, Guo H, Ma L. Thoracic epidural anesthesia improves outcomes in patients undergoing cardiac surgery: meta-analysis of randomized controlled trials. Eur J Med Res. 2015;20(1):25. https://doi.org/10.1186/s40001-015-0091-y.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kowalewski R, Seal D, Tang T, Prusinkiewicz C, Ha D. Neuraxial anesthesia for cardiac surgery: thoracic epidural and high spinal anesthesia - why is it different? HSR Proc Intensive Care Cardiovasc Anesth. 2011;3(1):25–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. • Liu H, Emelife PI, Prabhakar A, Moll V, Kendrick JB, Parr AT, et al. Regional anesthesia considerations for cardiac surgery. Best Pract Res Clin Anaesthesiol. 2019;33(4):387–406. https://doi.org/10.1016/j.bpa.2019.07.008. This article compares the various regional techniques for cardiac surgery.

    Article  PubMed  Google Scholar 

  5. •• Devarajan J, Balasubramanian S, Nazarnia S, Lin C, Subramaniam K. Regional analgesia for cardiac surgery part 1. Current status of neuraxial and paravertebral blocks for adult cardiac surgery. Semin Cardiothorac Vasc Anesth. 2021;25(4):252–64. https://doi.org/10.1177/10892532211023337. This article discusses the utility of neuraxial and paravertebral blocks for cardiac surgery.

    Article  PubMed  Google Scholar 

  6. Hemmerling TM, Cyr S, Terrasini N. Epidural catheterization in cardiac surgery: the 2012 risk assessment. Ann Card Anaesth. 2013;16(3):169–77. https://doi.org/10.4103/0971-9784.114237.

    Article  PubMed  Google Scholar 

  7. Shams D, Sachse K, Statzer N, Gupta RK. Regional anesthesia complications and contraindications. Clin Sports Med. 2022;41(2):329–43. https://doi.org/10.1016/j.csm.2021.11.006.

    Article  PubMed  Google Scholar 

  8. Kanda H, Kamiya H, Takahoko K, Yamaya S, Kudo E, Kunisawa T. Awake double valve surgery without general anesthesia. J Clin Anesth. 2019;56:117–8. https://doi.org/10.1016/j.jclinane.2019.01.025.

    Article  PubMed  Google Scholar 

  9. Barnwal NK, Bhaskar VS, Jain KL. High thoracic epidural anesthesia and dexmedetomidine for awake off-pump coronary artery bypass grafting: a feasible option for patients with severe pulmonary disease. Ann Card Anaesth. 2023;26(3):321–4. https://doi.org/10.4103/aca.aca_153_22.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Svircevic V, van Dijk D, Nierich AP, Passier MP, Kalkman CJ, van der Heijden GJMG, et al. Meta-analysis of thoracic epidural anesthesia versus general anesthesia for cardiac surgery. Anesthesiology. 2011;114(2):271–82. https://doi.org/10.1097/ALN.0b013e318201d300.

    Article  CAS  PubMed  Google Scholar 

  11. •• Chiew JK, Low CJW, Zeng K, Goh ZJ, Ling RR, Chen Y, et al. Thoracic epidural anesthesia in cardiac surgery: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials. Anesth Analg. 2023;137(3):587–600. https://doi.org/10.1213/ane.0000000000006532. This article reveals the benefits of thoracic epidural analgesia in reducing ICU/hospital length of stay and decreasing postoperative complications.

    Article  PubMed  Google Scholar 

  12. Kowalski S, Goldie D, Maguire D, Arora RC, Girling L, Fransoo R, et al. High spinal anesthesia combined with general anesthesia versus general anesthesia alone: a retrospective cohort study in cardiac surgical patients. Acta Anaesthesiol Belg. 2019;70(2):63–70.

    Google Scholar 

  13. Ruppen W, Derry S, McQuay HJ, Moore RA. Incidence of epidural haematoma and neurological injury in cardiovascular patients with epidural analgesia/anaesthesia: systematic review and meta-analysis. BMC Anesthesiol. 2006;6(1):10. https://doi.org/10.1186/1471-2253-6-10.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Guay J, Kopp S. Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass. Cochrane Database Syst Rev. 2019(3). https://doi.org/10.1002/14651858.CD006715.pub3.

  15. Onan B, Onan IS, Kilickan L, Sanisoglu I. Effects of epidural anesthesia on acute and chronic pain after coronary artery bypass grafting. J Card Surg. 2013;28(3):248–53. https://doi.org/10.1111/jocs.12086.

    Article  PubMed  Google Scholar 

  16. Sen AC, Rajan S, Balachandran R, Kumar L, Nair SG. Comparison of perioperative thoracic epidural fentanyl with bupivacaine and intravenous fentanyl for analgesia in patients undergoing coronary artery bypass grafting surgery. Anesth Essays Res. 2017;11(1):105–9. https://doi.org/10.4103/0259-1162.186613.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Akdoğan A, Ertürk E, Özdemir AC, Kutanis D, Güven KY. The effect of thoracic epidural analgesia on short-term outcome and mortality in geriatric patients undergoing open heart surgery. Ulus Travma Acil Cerrahi Derg. 2022;28(3):382–9. https://doi.org/10.14744/tjtes.2022.57995.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Hanada S, Kurosawa A, Randall B, Horst TVD, Ueda K. Impact of high spinal anesthesia technique on fast-track strategy in cardiac surgery: retrospective study. Reg Anesth Pain Med. 2020;45(1):22–6. https://doi.org/10.1136/rapm-2018-100213.

    Article  PubMed  Google Scholar 

  19. • Elmiro GS, Souza AH, Loyola SO, Prudente ML, Kushida CL, Carvalho JOS, et al. Spinal anesthesia increases the frequency of extubation in the operating room and decreases the time of mechanical ventilation after cardiac surgery. Braz J Cardiovasc Surg. 2021;36(1):32–8. https://doi.org/10.21470/1678-9741-2019-0433. This article highlights the pulmonary benefits of neuraxial anesthesia in cardiac surgery.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Young E, Sedghi S, Farzin H, Graffeo N, Sakha H, Nader ND. Do intrathecal opioids improve surgical outcomes after coronary artery bypass grafting? A systematic review and analysis. Pain Physician. 2023;26(4):319–26.

    PubMed  Google Scholar 

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Acknowledgements

The authors would like to thank Dr. Lisa Wofford (Chief of Anesthesiology at Ben Taub General Hospital) and Dr. Lee Chang (Anesthesiology Program Director at Baylor College of Medicine) for the continued support.

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Authors

Contributions

K.C. reviewed neuraxial anesthesia for cardiac surgery and contributed to that section of the manuscript. K.G. reviewed neuraxial analgesia for cardiac surgery and contributed to that section of the manuscript. T.L. contributed to the introduction of the manuscript. A.N. contributed to the abstract, conclusion, and is the corresponding author for the manuscript. All authors reviewed the manuscript.

Corresponding author

Correspondence to Anvinh Nguyen.

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The authors declare that they have no competing interests.

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All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki Declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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Chen, K., Gashler, K., Li, T. et al. Neuraxial Anesthesia and Analgesia During Cardiothoracic Surgery: A Narrative Review. Curr Pain Headache Rep 28, 315–319 (2024). https://doi.org/10.1007/s11916-024-01235-5

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