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Pain Syndromes Secondary to Cluneal Nerve Entrapment

  • Neuropathic Pain (A Abd-Elsayaed, Section Editor)
  • Published:
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Abstract

Purpose of Review

The purpose of this review is to provide an overview of the cluneal nerves, present a summary of pain syndromes secondary to clunealgia, and evaluate current literature for diagnostic and treatment modalities.

Recent Findings

Multiple trials and studies have reported success with numerous modalities ranging from nerve blocks, neuroablation, and even peripheral neuromodulation with varying degrees of clinical benefit.

Summary

Cluneal nerve entrapment or chronic impingement can cause buttock pain or referred pain to nearby areas including the lower back, pelvic area, or even the lower extremities. Clunealgias and associated pain syndromes can often be challenging to diagnose and differentiate. An appreciation of the pathophysiology of clunealgias can assist with patient selection for interventional pain strategies targeted towards the cluneal nerves, including nerve blocks, neuroablation, and peripheral neuromodulation. More research is needed to better delineate the efficacy of these procedures for clunealgias.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Kikuta S, Iwanaga J, Watanabe K, Tubbs RS. Revisiting the middle cluneal nerves: an anatomic study with application to pain syndromes and invasive procedures around the sacrum. World Neurosurg. 2019;127:1228–31 Anatomy and pain syndromes related to MCN.

    Article  Google Scholar 

  2. Dallas-Prunskis T. Inferior cluneal nerve entrapment. Peripheral nerve entrapments. Spinger. Cham. 2016;52:565–70.

    Google Scholar 

  3. Tubbs RS, Levin MR, Loukas M, Potts EA, Cohen-Gadol AA. Anatomy and landmarks for the superior and middle cluneal nerves: application to posterior iliac crest harvest and entrapment syndromes. J Neurosurg Spine. 2010;13(3):356–9.

    Article  Google Scholar 

  4. • Isu T, Kim K, Morimoto D, Iwamoto N. Superior and middle cluneal nerve entrapment as a cause of low back pain. Neurospine. 2018;15(1):25–32. https://doi.org/10.14245/ns.1836024.012Diagnosis of SCN and MCN nerve entrapment.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Konno T, Aota Y, Saito T, Qu N, Hayashi S, Kawata S, et al. Anatomical study of middle cluneal nerve entrapment. J Pain Res. 2017;10:1431–5.

    Article  Google Scholar 

  6. Aota Y. Entrapment of middle cluneal nerves as an unknown cause of low back pain. World J Orthop. 2016;7(3):167–70.

    Article  Google Scholar 

  7. • Nielsen TD, Moriggl B, Barckman J, et al. Randomized trial of ultrasound-guided superior cluneal nerve block. Reg Anesth Pain Med. 2019;44:772–80 Ultrasound guided nerve blocks of SCN.

    Article  Google Scholar 

  8. Mehta P. Peripheral nerve stimulation. In: Deer's treatment of pain 2019. Cham: Springer. p. 607–14.

  9. Deer T, Pope J, Benyamin R, Vallejo R, Friedman A, Caraway D, et al. Prospective, multicenter, randomized, double-blinded, partial crossover study to assess the safety and efficacy of the novel neuromodulation system in the treatment of patients with chronic pain of peripheral nerve origin. Neuromodulation. 2016;19(1):91–100.

    Article  Google Scholar 

  10. Abd-Elsayed A. Wireless peripheral nerve stimulation for treatment of peripheral neuralgias. Neuromodulation: Technology at the Neural Interface. 2020.

  11. McRoberts WP, Deer TR, Abejon D, Barolat G. Stimulation of the extraspinal peripheral nervous system. In: Deer TR, Pope JE, editors. Atlas of implantable therapies for pain management. New York: Springer Science; 2016. p. 171–83.

    Chapter  Google Scholar 

  12. Darnis B, Robert R, Labat J, et al. Perineal pain and inferior cluneal nerves: anatomy and surgery. Surg Radiol Anat. 2008;30(3):177–83.

    Article  CAS  Google Scholar 

  13. Iwanaga J, Simonds E, Patel M, et al. Anatomic study of superior cluneal nerves: application to low back pain and surgical approaches to lumbar vertebrae. World Neurosurg. 2018;116:766–8.

    Article  Google Scholar 

  14. Maigne JY, Doursounian L. Entrapment neuropathy of the medial superior cluneal nerve: nineteen cases surgically treated, with a minimum of 2 years’ follow-up. Spine. 1997;22(10):1156–9.

    Article  CAS  Google Scholar 

  15. Bodner G, Platzgummer H, Meng S, Brugger PC, Gruber GM, Lieba-Samal D. Successful identification and assessment of the superior cluneal nerves with high-resolution sonography. Pain Physician. 2016;19(3):197–202.

    PubMed  Google Scholar 

  16. Ermis MN, Yildirim D, Durakbasa MO, et al. Medial superior cluneal nerve entrapment neuropathy in military personnel; diagnosis and etiologic factors. J Back Musculoskelet Rehabil. 2011;24(3):137–44.

    Article  Google Scholar 

  17. Nielsen TD, Moriggl B, Barckman J, Jensen JM, Kolsen-Petersen JA, Søballe K, et al. Randomized trial of ultrasound-guided superior cluneal nerve block. Reg Anesth Pain Med. 2019;44:772–80.

    Article  Google Scholar 

  18. Chang KV, Wu WT. Is it possible to exactly visualize the superior cluneal nerve using ultrasound imaging?. Reg Anesth Pain Med. 2019:rapm-2019.

  19. • Knight M, Karangoda I, Ahmed RN, D’Angelo T, Inklebarger J, Abbas B, et al. A radiofrequency treatment pathway for cluneal nerve disorders. EC Orthopaedics. 2020; Radiofrequency ablation for cluneal nerve disorders.

  20. Talu GK, Özyalçin S, Talu U. Superior cluneal nerve entrapment. Reg Anesth Pain Med. 2000;25:6.

    Article  Google Scholar 

  21. Brinks A, Koes BW, Volkers AC, Verhaar JA, Bierma-Zeinstra SM. Adverse effects of extra-articular corticosteroid injections: a systematic review. BMC Musculoskelet Disord. 2010;11(1):206.

    Article  Google Scholar 

  22. Inklebarger J, Galanis N. The management of cluneal nerve referred pain with prolotherapy. J Prolotherapy. 2018;10:982–91.

    Google Scholar 

  23. Ramamurthy S, Walsh NE, Schoenfeld LS, Hoffman J. Evaluation of neurolytic blocks using phenol and cryogenic block in the management of chronic pain. J Pain Symptom Manag. 1989;4(2):72–5.

    Article  CAS  Google Scholar 

  24. Karri J, Mas MF, Francisco GE, Li S. Practice patterns for spasticity management with phenol neurolysis. J Rehabil Med. 2017;49(6):482–8.

    Article  Google Scholar 

  25. Vorobeychik Y Optimal performance of RFA of the nerves supplying the posterior sacroiliac joint complex. https://clinicaltrials.gov/ct2/show/NCT02808962. Updated March 30, 2020. Accessed April 27, 2020.

  26. Slavin KV. Peripheral nerve stimulation for neuropathic pain. Neurotherapeutics. 2008 Jan 1;5(1):100–6.

    Article  Google Scholar 

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Correspondence to Jay Karri.

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Jay Karri, Mani Singh, Vwaire Orhurhu, Mihir Joshi, and Alaa Abd-Elsayed declare no conflict of interest.

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This article is part of the Topical Collection on Neuropathic Pain

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Karri, J., Singh, M., Orhurhu, V. et al. Pain Syndromes Secondary to Cluneal Nerve Entrapment. Curr Pain Headache Rep 24, 61 (2020). https://doi.org/10.1007/s11916-020-00891-7

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  • DOI: https://doi.org/10.1007/s11916-020-00891-7

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