Skip to main content

Advertisement

Log in

Management of Patients on Abuse-Deterrent Opioids in the Ambulatory Surgery Setting

  • Other Pain (N Vadivelu and A Kaye, Section Editors)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The use of prescription opioids for acute and chronic pain has become more prevalent than ever, and concurrent with the increased prescribing of opioids, there has been a steady increase in opioid abuse. Abuse is commonly associated with physical or chemical manipulation of the original opiate to provide more rapid onset of the active ingredient.

Recent Findings

This growing national public health concern has led to the development of various abuse-deterring opioids with the intent of decreasing the diversion of opioids from their prescribed use. Given the ever-increasing percentage of surgeries performed in the ambulatory surgery setting, anesthesia providers will inevitably encounter more and more patients taking these new opioid formulations with abuse-deterring properties. Consequently, a thorough understanding of these medications is vital for optimal anesthetic management.

Summary

This article reviews the scope of the problem of prescription opiate abuse, summarizes the currently available abuse-deterring opioids, and discusses the anesthetic management of patients who are taking these new medications in the outpatient setting.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Nahin RL. Estimates of pain prevalence and severity in adults: United States, 2012. J Pain. 2015;16(8):769–80. Pubmed Central PMCID: 4562413.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Trescot AM, Boswell MV, Atluri SL, Hansen HC, Deer TR, Abdi S, et al. Opioid guidelines in the management of chronic non-cancer pain. Pain Physician. 2006;9(1):1–39.

    PubMed  Google Scholar 

  3. • Manchikanti L, Fellows B, Ailinani H, Pampati V. Therapeutic use, abuse, and nonmedical use of opioids: a ten-year perspective. Pain Physician. 2010;13(5):401–35. PMID: 20859312. Reviews the demographics of substance abuse over the past 10 years, including prevalence of abuse/misuse and number of prescriptions being written for opioid analgesics.

    PubMed  Google Scholar 

  4. Abdel Shaheed C, Maher CG, Williams KA, Day R, McLachlan AJ. Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(7):958–68.

    Article  PubMed  Google Scholar 

  5. Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137–62.

    Article  CAS  PubMed  Google Scholar 

  6. Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113–30. Pubmed Central PMCID: 4043401.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gugelmann HM, Perrone J. Can prescription drug monitoring programs help limit opioid abuse? JAMA. 2011;306(20):2258–9.

    Article  CAS  PubMed  Google Scholar 

  8. American Hospital Association. Utilization and volume [cited 2016 August 14]. Available from: http://www.aha.org/research/reports/tw/chartbook/index.shtml.

  9. Wier LM, Steiner CA, Owens PL. Surgeries in Hospital-Owned Outpatient Facilities, 2012. HCUP Statistical Brief #188. February 2015. Agency for Healthcare Research and Quality, Rockville, MD. http://www.hcupus.ahrq.gov/reports/statbriefs/sb188-Surgeries-Hospital-Outpatient-Facilities-2012.pdf.

  10. Whippey A, Kostandoff G, Paul J, Ma J, Thabane L, Ma HK. Predictors of unanticipated admission following ambulatory surgery: a retrospective case-control study. Can J Anesth. 2013;60(7):675–83.

    Article  PubMed  Google Scholar 

  11. Schneider JP, Matthews M, Jamison RN. Abuse-deterrent and tamper-resistant opioid formulations: what is their role in addressing prescription opioid abuse? CNS Drugs. 2010;24(10):805–10.

    Article  CAS  PubMed  Google Scholar 

  12. Frymoyer JW, Cats-Baril WL. An overview of the incidences and costs of low back pain. Orthop Clin North Am. 1991;22(2):263–71.

    CAS  PubMed  Google Scholar 

  13. Webster L. Update on abuse-resistant and abuse-deterrent approaches to opioid formulations. Pain Med. 2009;10 Suppl 2:S124–33.

    Article  PubMed  Google Scholar 

  14. Smith SM, Dart RC, Katz NP, Paillard F, Adams EH, Comer SD, et al. Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations. Pain. 2013;154(11):2287–96.

    Article  PubMed  Google Scholar 

  15. • Bannwarth B. Will abuse-deterrent formulations of opioid analgesics be successful in achieving their purpose? Drugs. 2012;72(13):1713–23. PubMed PMID: 22931520. Reviews various classes of abuse-deterrent formulations and postulates as to whether they would be successful in clinical application.

    Article  CAS  PubMed  Google Scholar 

  16. Stanos SP, Bruckenthal P, Barkin RL. Strategies to reduce the tampering and subsequent abuse of long-acting opioids: potential risks and benefits of formulations with physical or pharmacologic deterrents to tampering. Mayo Clin Proc. 2012;87(7):683–94. Pubmed Central PMCID: 3498428.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Administration SAaMHS. In: Services UDoHaH, editor. SAMHSA 2007 national survey of drug use and helath: detailed tables. 2007.

    Google Scholar 

  18. Dhalla IA, Persaud N, Juurlink DN. Facing up to the prescription opioid crisis. BMJ. 2011;343:d5142.

    Article  PubMed  Google Scholar 

  19. Grady D, Berkowitz SA, Katz MH. Opioids for chronic pain. Arch Intern Med. 2011;171(16):1426–7.

    Article  PubMed  Google Scholar 

  20. Nicholson B. Responsible prescribing of opioids for the management of chronic pain. Drugs. 2003;63(1):17–32.

    Article  PubMed  Google Scholar 

  21. Woodcock J. A difficult balance–pain management, drug safety, and the FDA. N Engl J Med. 2009;361(22):2105–7.

    Article  CAS  PubMed  Google Scholar 

  22. Crim OoDa. In: Nations U, editor. World drug report 2015. 2015.

    Google Scholar 

  23. Administration SAaMHS. In: Services DoHaH, editor. Results from the 2013 national survey on drug use and health: summary of national findings. 2013.

    Google Scholar 

  24. Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merrill JO, Sullivan MD, et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med. 2010;152(2):85–92. Pubmed Central PMCID: 3000551.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011;305(13):1315–21.

    Article  CAS  PubMed  Google Scholar 

  26. Okie S. A flood of opioids, a rising tide of deaths. N Engl J Med. 2010;363(21):1981–5.

    Article  CAS  PubMed  Google Scholar 

  27. Holmes D. Prescription drug addiction: the treatment challenge. Lancet. 2012;379(9810):17–8.

    Article  PubMed  Google Scholar 

  28. Centers for Disease C, Prevention. Emergency department visits involving nonmedical use of selected prescription drugs—United States, 2004–2008. MMWR Morb Mortal Wkly Rep. 2010;59(23):705–9.

    Google Scholar 

  29. Nelson LS, Perrone J. Curbing the opioid epidemic in the United States: the risk evaluation and mitigation strategy (REMS). JAMA. 2012;308(5):457–8.

    Article  CAS  PubMed  Google Scholar 

  30. Casty FE, Wieman MS, Shusterman N. Current topics in opioid therapy for pain management: addressing the problem of abuse. Clin Drug Investig. 2013;33(7):459–68.

    Article  CAS  PubMed  Google Scholar 

  31. Vadivelu N, Schermer E, Kodumudi G, Berger JM. The clinical applications of extended-release abuse-deterrent opioids. CNS Drugs. 2016;30(7):637–46.

    Article  CAS  PubMed  Google Scholar 

  32. •• Abuse-Deterrent Opioids - Evaluation and Labeling Guidance for Industry. US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research. 2015 April 2015. Guidelines for the development of abuse-deterring opioids that were developed by the US Department of Health. Categorizes these medications into classes based on mechanism of action

  33. •• Timeline of Selected FDA Activities and Significant Events Addressing Opioid Misuse and Abuse. 2016 5/27/2016. Timeline of events when certain abuse-deterrent opioids were developed and whether or not they subsequently received FDA abuse-deterrent status

  34. • Mastropietro DJ, Omidian H. Abuse-deterrent formulations: part 2: commercial products and proprietary technologies. Expert Opin Pharmacother. 2015;16(3):305–23. PubMed PMID: 25421961. Reviews various classes of abuse-deterrent formulations and goes over timeline of events when certain drugs were developed and received FDA abuse-deterrent status.

    CAS  PubMed  Google Scholar 

  35. Gasior M, Bond M, Malamut R. Routes of abuse of prescription opioid analgesics: a review and assessment of the potential impact of abuse-deterrent formulations. Postgrad Med. 2016;128(1):85–96.

    Article  PubMed  Google Scholar 

  36. Bulloch M. Abuse-deterrent opioids: a primer for pharmacists. 2015. Epub October 20, 2015

  37. Zohydro ER, Pernix Therapeutics Online2015 [8/20/2016]. Available from: www.zohydroer.com.

  38. Burness CB, Keating GM. Oxycodone/Naloxone prolonged-release: a review of its use in the management of chronic pain while counteracting opioid-induced constipation. Drugs. 2014;74(3):353–75.

    Article  CAS  PubMed  Google Scholar 

  39. Moorman-Li R, Motycka CA, Inge LD, Congdon JM, Hobson S, Pokropski B. A review of abuse-deterrent opioids for chronic nonmalignant pain. P & T : a peer-reviewed journal for formulary management. 2012;37(7):412–8. Pubmed Central PMCID: 3411218.

    Google Scholar 

  40. Badalamenti VC, Buckley JW, Smith ET. Safety of EMBEda (morphine sulfate and naltrexone hydrochloride) extended-release capsules: review of postmarketing adverse events during the first year. JOpioid Manag. 2012;8(2):115–25.

    Article  PubMed  Google Scholar 

  41. Sigmon SC, Moody DE, Nuwayser ES, Bigelow GE. An injection depot formulation of buprenorphine: extended bio-delivery and effects. Addiction. 2006;101(3):420–32.

    Article  PubMed  Google Scholar 

  42. Gudin JA, Nalamachu SR. An overview of prodrug technology and its application for developing abuse-deterrent opioids. Postgrad Med. 2016;128(1):97–105.

    Article  PubMed  Google Scholar 

  43. Bryson EO, Lipson S, Gevirtz C. Anesthesia for patients on buprenorphine. Anesthesiol Clin. 2010;28(4):611–7.

    Article  CAS  PubMed  Google Scholar 

  44. Alford DP, Compton P, Samet JH. Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. Ann Intern Med. 2006;144(2):127–34. Pubmed Central PMCID: 1892816.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Vadivelu N, Mitra S, Kaye AD, Urman RD. Perioperative analgesia and challenges in the drug-addicted and drug-dependent patient. Best Pract Res Clin Anaesthesiol. 2014;28(1):91–101.

    Article  PubMed  Google Scholar 

  46. Roberts DM, Meyer-Witting M. High-dose buprenorphine: perioperative precautions and management strategies. Anaesth Intensive Care. 2005;33(1):17–25.

    CAS  PubMed  Google Scholar 

  47. Cullen KA, Hall MJ, Golosinskiy A. Ambulatory surgery in the United States, 2006: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics; 2009

  48. McGrath B, Chung F. Postoperative recovery and discharge. Anesthesiol Clin North Am. 2003;21(2):367–86.

    Article  Google Scholar 

  49. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97(2):534–40.

    Article  PubMed  Google Scholar 

  50. Carroll IR, Angst MS, Clark JD. Management of perioperative pain in patients chronically consuming opioids. Reg Anesth Pain Med. 2004;29(6):576–91.

    Article  PubMed  Google Scholar 

  51. Apfel C, Jahr JR, Kelly CL, Ang RY, Oderda GM. Effect of i.v. acetaminophen on total hip or knee replacement surgery: a case-matched evaluation of a national patient database. Am J Health Syst Pharm. 2015;72(22):1961–8.

    Article  CAS  PubMed  Google Scholar 

  52. Hadzic A, Williams BA, Karaca PE, Hobeika P, Unis G, Dermksian J, et al. For outpatient rotator cuff surgery, nerve block anesthesia provides superior same-day recovery over general anesthesia. Anesthesiology. 2005;102(5):1001–7.

    Article  CAS  PubMed  Google Scholar 

  53. Liu SS, Strodtbeck WM, Richman JM, Wu CL. A comparison of regional versus general anesthesia for ambulatory anesthesia: a meta-analysis of randomized controlled trials. Anesth Analg. 2005;101(6):1634–42.

    Article  PubMed  Google Scholar 

  54. Pavlin DJ, Chen C, Penaloza DA, Buckley FP. A survey of pain and other symptoms that affect the recovery process after discharge from an ambulatory surgery unit. J Clin Anesth. 2004;16(3):200–6.

    Article  PubMed  Google Scholar 

  55. Rana MV, Desai R, Tran L, Davis DA. Perioperative pain control in the ambulatory setting. Curr Pain Headache Rep. 2016;20(3):1–9.

    Article  Google Scholar 

  56. Mitra S, Sinatra RS. Perioperative management of acute pain in the opioid-dependent patient. Anesthesiology. 2004;101(1):212–27.

    Article  PubMed  Google Scholar 

  57. Rapp SE, Ready LB, Nessly ML. Acute pain management in patients with prior opioid consumption: a case-controlled retrospective review. Pain. 1995;61(2):195–201.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nalini Vadivelu.

Ethics declarations

Conflict of Interest

Nalini Vadivelu, Daniel Chang, Leandro Lumermann, Thomas Suchy, and Matthew M. Burg declare that they have no conflict of interest.

Manuel L. Fontes declares personal fees from Grifols Pharmaceutical for serving as a speaker.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Other Pain

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vadivelu, N., Chang, D., Lumermann, L. et al. Management of Patients on Abuse-Deterrent Opioids in the Ambulatory Surgery Setting. Curr Pain Headache Rep 21, 10 (2017). https://doi.org/10.1007/s11916-017-0612-1

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11916-017-0612-1

Keywords

Navigation