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Animal Models of Chronic Migraine

  • Chronic Daily Headache (SJ Wang, Section Editor)
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Abstract

Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when their underlying pathophysiology is likely to be the same and that migraine frequency probably depends on complex polygenic influences remains to be determined. Any model of chronic migraine must reflect the chronicity of the disorder and be reliable and validated with pharmacological interventions. Future animal models of chronic migraine are likely to involve recurrent activation of the trigeminal nociceptive system. Valid models would provide a means for investigating pathophysiological mechanism of the transformation from episodic to chronic migraine and may also be used to test the efficacy of potential preventive medications.

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Dr. Robin James Storer, Dr. Weera Supronsinchai, and Dr. Anan Srikiatkhachorn each declare no potential conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Department of Physiology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand

    Robin James Storer, Weera Supronsinchai & Anan Srikiatkhachorn

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  1. Robin James Storer
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Correspondence to Anan Srikiatkhachorn.

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Storer, R.J., Supronsinchai, W. & Srikiatkhachorn, A. Animal Models of Chronic Migraine. Curr Pain Headache Rep 19, 467 (2015). https://doi.org/10.1007/s11916-014-0467-7

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