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Diabetes and the Microvasculature of the Bone and Marrow

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Abstract

Purpose of Review

The purpose of this review is to highlight the evidence of microvascular dysfunction in bone and marrow and its relation to poor skeletal outcomes in diabetes mellitus.

Recent Findings

Diabetes mellitus is characterized by chronic hyperglycemia, which may lead to microangiopathy and macroangiopathy. Micro- and macroangiopathy have been diagnosed in Type 1 and Type 2 diabetes, coinciding with osteopenia, osteoporosis, enhanced fracture risk and delayed fracture healing. Microangiopathy has been reported in the skeleton, correlating with reduced blood flow and perfusion, vasomotor dysfunction, microvascular rarefaction, reduced angiogenic capabilities, and augmented vascular permeability.

Summary

Microangiopathy within the skeleton may be detrimental to bone and manifest as, among other clinical abnormalities, reduced mass, enhanced fracture risk, and delayed fracture healing. More investigations are required to elucidate the various mechanisms by which diabetic microvascular dysfunction impacts the skeleton.

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  1. Bone Vascular and Microcirculation Laboratory, Department of Kinesiology, University of Texas at Arlington, Arlington, TX, 76019, USA

    Teresa Le, Amanda Salas Sanchez, Danyah Nashawi, Sunidhi Kulkarni & Rhonda D. Prisby

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Le, T., Salas Sanchez, A., Nashawi, D. et al. Diabetes and the Microvasculature of the Bone and Marrow. Curr Osteoporos Rep 22, 11–27 (2024). https://doi.org/10.1007/s11914-023-00841-3

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