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Osteoblasts: a Novel Source of Erythropoietin

  • Skeletal Development (E Schipani and E Zelzer, Section Editors)
  • Published:
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Abstract

Osteoblasts are an important cellular component of the bone microenvironment controlling bone formation and hematopoiesis. Understanding the cellular and molecular mechanisms by which osteoblasts regulate these processes is a rapidly growing area of research given the important implications for bone therapy, regenerative medicine, and hematopoietic stem cell transplantation. Here we summarize our current knowledge regarding the cellular and molecular crosstalk driving bone formation and hematopoiesis and will discuss the implications of a recent finding demonstrating that osteoblasts are a cellular source of erythropoietin .

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Conflict of Interest

C. Wu, A. J. Giaccia, and E. B. Rankin declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

All studies by C. Wu, A. J. Giaccia, and E. B. Rankin involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.

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Authors and Affiliations

  1. Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University, Stanford, CA, 94303-5152, USA

    Colleen Wu, Amato J. Giaccia & Erinn B. Rankin

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  1. Colleen Wu
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  2. Amato J. Giaccia
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  3. Erinn B. Rankin
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Correspondence to Erinn B. Rankin.

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Wu, C., Giaccia, A.J. & Rankin, E.B. Osteoblasts: a Novel Source of Erythropoietin. Curr Osteoporos Rep 12, 428–432 (2014). https://doi.org/10.1007/s11914-014-0236-x

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  • DOI: https://doi.org/10.1007/s11914-014-0236-x

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