Abstract
Purpose of Review
Breast cancer is currently the most prevalent cancer diagnosed globally, and there is a significant gap in the availability of effective first-line treatment options. In addition to a cancer diagnosis, breast cancer patients face additional pain and morbidity after treatment. Radiation fibrosis, muscle spasms, muscle pain, neuropathy, and limited shoulder function are all potential side effects of breast cancer treatment and breast reconstruction. Post-mastectomy pain syndrome affects 25–60% of people after breast surgery. The current review moves forward to explain interventional pain management options that can be used to supplement conservative measures (physical therapy, medication, topical ointments) to help these patients.
Recent Findings
There are many new interventional procedures to treat chest wall pain, neuropathic pain, and spasticity after breast surgery. Currently, the most commonly performed procedures are botulinum toxin injections, serratus anterior plane blocks, intercostobrachial nerve blocks, thoracic paravertebral nerve blocks, pectoralis nerve blocks, and erector spinae nerve blocks.
Summary
Utilizing one of these interventional procedures, along with physical therapy and pharmacologic interventions, can help manage post-mastectomy pain syndrome in the millions of breast cancer patients diagnosed and treated every year.
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References
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Fahad UM. Breast cancer: current perspectives on the disease status. Breast Cancer Metastasis and Drug Resistance: Challenges and Progress 2019:51–64.
Tan PY, Anand SP, Chan DXH. Post-mastectomy pain syndrome: a timely review of its predisposing factors and current approaches to treatment. Proc Singap Healthc. 2022;31:20101058211006420. This study presents an overview of the leading causes of post-mastecomy pain and viable treatment options.
Wijayasinghe N, Duriaud HM, Kehlet H, Anderson KG. Ultrasound guided intercostobrachial nerve blockade in patients with persistent pain after breast cancer surgery: a pilot study. Pain Physician. 2016;19(2):E309.
Kokosis G, Chopra K, Darrach H, Dellon AL, Williams EH. Re-visiting post-breast surgery pain syndrome: risk factors, peripheral nerve associations and clinical implications. Gland Surgery. 2019;8(4):407.
Khanna A. Role of interventional pain management in breast cancer. In: Breast cancer and gynecologic cancer rehabilitation. Elsevier; 2021. p. 141–8. This study entails important causes and recommended interventional procedures for post-mastectomy pain.
Fazekas D, Doroshenko M, Horn DB. Intercostal neuralgia. InStatPearls [Internet]. StatPearls Publishing; 2022.
Wisotzky E, Hanrahan N, Lione TP, Maltser S. Deconstructing postmastectomy syndrome: implications for physiatric management. Phys Med Rehabil Clin N Am. 2017;28(1):153–69. https://doi.org/10.1016/j.pmr.2016.09.003.
Stubblefield MD. Clinical evaluation and management of radiation fibrosis syndrome. Phys Med Rehabil Clin N Am. 2017;28(1):89–100. https://doi.org/10.1016/j.pmr.2016.08.003.
Yang S, Park DH, Ahn SH, Kim J, Lee JW, Han JY, et al. Prevalence and risk factors of adhesive capsulitis of the shoulder after breast cancer treatment. Support Care Cancer. 2017;25(4):1317–22. https://doi.org/10.1007/s00520-016-3532-4.
Lee CH, Chung SY, Kim WY, Yang SN. Effect of breast cancer surgery on chest tightness and upper limb dysfunction. Medicine (Baltimore). 2019;98(19):e15524. https://doi.org/10.1097/2FMD.0000000000015524.
Lang AE, Dickerson CR, Kim SY, Stobart J, Milosavljevic S. Impingement pain affects kinematics of breast cancer survivors in work-related functional tasks. Clin Biomech. 2019;1(70):223–30. https://doi.org/10.1016/j.clinbiomech.2019.10.001.
Neto CM, Pezarat P, Oliveira R. Effects of breast cancer treatment on shoulder function: What to expect and how to treat? Int J Phys Ther Rehab 2018;4:147. https://doi.org/10.15344/2455-7498/2018/147.
Dibbs R, Trost J, DeGregorio V, Izaddoost S. Free tissue breast reconstruction. Semin Plast Surg. 2019;33(1):59–66. https://doi.org/10.1055/s-0039-1677703.
Tuohy SM. Current concepts in rehabilitation following breast reconstruction surgery. Rehabilitation Oncology. 2005;23(2):14–7.
Zehm A, Kamdar M. Palliative uses of botulinum neurotoxin #324. J Palliat Med. 2017;20(3):300–2. https://doi.org/10.1089/jpm.2016.0498. This study describes the detailed mechanism of botulinum toxin injections, a recommended option with minimal side effects in management of post-mastectomy pain.
Egeo G, Fofi L, Barbanti P. Botulinum neurotoxin for the treatment of neuropathic pain. Front Neurol. 2020;11(11):716. https://doi.org/10.3389/fneur.2020.00716.
Safarpour Y, Jabbari B. Botulinum toxin treatment of pain syndromes–an evidence based review. Toxicon. 2018;147:120–8. https://doi.org/10.1016/j.toxicon.2018.01.017.
Zocca JA, Chen GH, Puttanniah VG, Hung JC, Gulati A. Ultrasound-guided serratus plane block for treatment of postmastectomy pain syndromes in breast cancer patients: a case series. Pain Pract. 2017;17(1):141–6. https://doi.org/10.1111/papr.12482. This study describes the the serratus plane block in management of post-mastectomy pain.
Datu MD, Prasetyadhi J. Serratus anterior plane block in modified radical mastectomy surgery: a case series. JA Clin Rep. 2020;6:1–4. https://doi.org/10.1186/s40981-020-00373-0.
Edwards JT, Langridge XT, Cheng GS, McBroom MM, Minhajuddin A, Machi AT. Superficial vs deep serratus anterior plane block for analgesia in patients undergoing mastectomy: a randomized prospective trial. J Clin Anesth. 2021;75:110470. https://doi.org/10.1016/j.jclinane.2021.110470.
Zheng C, Wang J, Xie S. Ultrasound-guided thoracic paravertebral nerve block on postoperative pain, quality of life, and recovery in patients with non-small-cell lung cancer. Biomed Res Int. 2021;2021:1–6. https://doi.org/10.1155/2021/6692815.
Richardson J, Lönnqvist P. Thoracic paravertebral block. Br J Anaesth. 1998;81(2):230–8. https://doi.org/10.1093/bja/81.2.230.
Ueshima H, Otake H, Hara E, Blanco R. How to use pectoral nerve blocks effectively—an evidence-based update. Asian J Anesthesiol. 2019;57(2):28–36. https://doi.org/10.6859/aja.201906_57(2).0002.
Forero M, Adhikary SD, Lopez H, Tsui C, Chin KJ. The erector spinae plane block: a novel analgesic technique in thoracic neuropathic pain. Reg Anesth Pain Med. 2016;41(5):621–7. https://doi.org/10.1097/AAP.0000000000000451.
Tulgar S, Ahiskalioglu A, De Cassai A, Gurkan Y. Efficacy of bilateral erector spinae plane block in the management of pain: current insights. J Pain Res. 2019:2597–613. https://doi.org/10.2147/jpr.s182128.
Vidal E, Giménez H, Forero M, Fajardo M. Erector spinae plane block: a cadaver study to determine its mechanism of action. Revista Española de Anestesiología y Reanimación (English Edition). 2018;65(9):514–9. This study illustrates the analgesic potential of the erector spinae plane block in post-mastectomy pain.
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Murugappan, A., Khanna, A. Interventional Treatment Options for Post-mastectomy Pain. Curr Oncol Rep 25, 1175–1179 (2023). https://doi.org/10.1007/s11912-023-01435-z
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DOI: https://doi.org/10.1007/s11912-023-01435-z