Skip to main content

Advertisement

Log in

Rehabilitation in Advanced Cancer Patients with Bone Metastases and Neural Compromise: Current Status and Future Directions

  • Cancer Rehabilitation (S Shahpar, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review aimed to increase the understanding of oncologists and physiatrists about the necessity, efficacy, and safety of rehabilitation in advanced cancer patients with bone metastases and neural compromise.

Recent Findings

Recently, there are growing evidence supporting the safety and efficacy of rehabilitation in patients with bone metastases and neural compromise. Despite the potential benefits of rehabilitation, however, rehabilitative services are considerably underutilized in clinical practice. Many oncologists are not familiar with functional issues and have limited understanding of the available rehabilitative services. Moreover, medical professionals, even physiatrists, have uncertainties and concerns about skeletal complications and often regard rehabilitation as a contraindication in this patient group.

Summary

This review aimed to raise awareness on the role of rehabilitation in the continuum of cancer treatment, to improve its use in clinical practice. A multidisciplinary team approach involving physiatrist may facilitate integration of relevant clinicians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Cheville A. Rehabilitation of patients with advanced cancer. Cancer. 2001;92:1039–48. https://doi.org/10.1002/1097-0142(20010815)92:4+%3c1039::aid-cncr1417%3e3.0.co;2-l.

    Article  CAS  PubMed  Google Scholar 

  2. Cromes G. Implementation of interdisciplinary cancer rehabilitation. Rehabil Couns Bull. 1978;21:230–7.

    Google Scholar 

  3. Okamura H. Importance of rehabilitation in cancer treatment and palliative medicine. Jpn J Clin Oncol. 2011;41:733–8. https://doi.org/10.1093/jjco/hyr061.

    Article  PubMed  Google Scholar 

  4. Chasen M, Bhargava R, MacDonald N. Rehabilitation for patients with advanced cancer. CMAJ. 2014;186:1071–5. https://doi.org/10.1503/cmaj.131402.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Stubblefield MD. The underutilization of rehabilitation to treat physical impairments in breast cancer survivors. PM&R. 2017;9:S317–23. https://doi.org/10.1016/j.pmrj.2017.05.010.

    Article  Google Scholar 

  6. Mitra R. Principles of rehabilitation medicine. New York: McGraw-Hill; 2019.

    Google Scholar 

  7. Jiang W, Rixiati Y, Zhao B, Li Y, Tang C, Liu J. Incidence, prevalence, and outcomes of systemic malignancy with bone metastases. J Orthop Surg (Hong Kong). 2020;28:1–5. https://doi.org/10.1177/2309499020915989.

    Article  Google Scholar 

  8. Macedo F, Ladeira K, Pinho F, Saraiva N, Bonito N, Pinto L, Gonçalves F. Bone metastases: an overview. Oncol Rev. 2017;11:321. https://doi.org/10.4081/oncol.2017.321.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shinoda Y, Sawada R, Yoshikawa F, Oki T, Hirai T, Kobayashi H, Matsudaira K, Oka H, Tanaka S, Kawano H. Factors related to the quality of life in patients with bone metastases. Clin Exp Metastasis. 2019;36:441–8. https://doi.org/10.1007/s10585-019-09983-0.

    Article  CAS  PubMed  Google Scholar 

  10. • Sheill G, Guinan EM, Peat N, Hussey J. Considerations for exercise prescription in patients with bone metastases: a comprehensive narrative review. PM R. 2018;10:843–64. https://doi.org/10.1016/j.pmrj.2018.02.006. This review gives a comprehensive summary of rehabilitation in patients with bone metastases.

  11. Wilk M, Kepski J, Kepska J, Casselli S, Szmit S. Exercise interventions in metastatic cancer disease: a literature review and a brief discussion on current and future perspectives. BMJ Support Palliat Care. 2020;10:404–10. https://doi.org/10.1136/bmjspcare-2020-002487.

    Article  PubMed  Google Scholar 

  12. Weller S, Hart NH, Bolam KA, Mansfield S, Santa Mina D, Winters-Stone KM, Campbell A, Rosenberger F, Wiskemann J, Quist M, Cormie P, Goulart J, Campbell KL. Exercise for individuals with bone metastases: a systematic review. Crit Rev Oncol Hematol. 2021;166: 103433. https://doi.org/10.1016/j.critrevonc.2021.103433.

    Article  PubMed  Google Scholar 

  13. Cormie P, Newton RU, Spry N, Joseph D, Taaffe DR, Galvão DA. Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases. Prostate Cancer Prostatic Dis. 2013;16:328–35. https://doi.org/10.1038/pcan.2013.22.

    Article  CAS  PubMed  Google Scholar 

  14. Weinfurt KP, Li Y, Castel LD, Saad F, Timbie JW, Glendenning GA, Schulman KA. The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol. 2005;16:579–84. https://doi.org/10.1093/annonc/mdi122.

    Article  CAS  PubMed  Google Scholar 

  15. Sheill G, Guinan E, Neill LO, Hevey D, Hussey J. Physical activity and advanced cancer: the views of oncology and palliative care physicians in Ireland. Ir J Med Sci. 2018;187:337–42. https://doi.org/10.1007/s11845-017-1677-x.

    Article  CAS  PubMed  Google Scholar 

  16. Zopf EM, Newton RU, Taaffe DR, Spry N, Cormie P, Joseph D, Chambers SK, Baumann FT, Bloch W, Galvão DA. Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: a cross-sectional investigation. Eur J Cancer Care (Engl). 2017;26: e12575. https://doi.org/10.1111/ecc.12575.

    Article  Google Scholar 

  17. Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51:2375–90. https://doi.org/10.1249/MSS.0000000000002116.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Keilani M, Kainberger F, Pataraia A, Hasenöhrl T, Wagner B, Palma S, Cenik F, Crevenna R. Typical aspects in the rehabilitation of cancer patients suffering from metastatic bone disease or multiple myeloma. Wien Klin Wochenschr. 2019;131:567–75. https://doi.org/10.1007/s00508-019-1524-3.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Coleman R, Hadji P, Body JJ, Santini D, Chow E, Terpos E, Oudard S, Bruland Ø, Flamen P, Kurth A, Van Poznak C, Aapro M, Jordan K. Bone health in cancer: ESMO clinical practice guidelines. Ann Oncol. 2020;31:1650–63. https://doi.org/10.1016/j.annonc.2020.07.019.

    Article  CAS  PubMed  Google Scholar 

  20. Bunting RW, Boublik M, Blevins FT, Dame CC, Ford LA, Lavine LS. Functional outcome of pathologic fracture secondary to malignant disease in a rehabilitation hospital. Cancer. 1992;69:98–102. https://doi.org/10.1002/1097-0142(19920101)69:1%3c98::aid-cncr2820690118%3e3.0.co;2-f.

    Article  CAS  PubMed  Google Scholar 

  21. Mirels H. Metastatic disease in long bones: a proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res. 1989;249:256–64. https://doi.org/10.1097/00003086-198912000-00027.

    Article  Google Scholar 

  22. Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the spine oncology study group. Spine (Phila Pa 1976). 2010;35:E1221–9. https://doi.org/10.1097/BRS.0b013e3181e16ae2

  23. Guo Y, Ngo-Huang AT, Fu JB. Perspectives on spinal precautions in patients who have cancer and spinal metastasis. Phys Ther. 2020;100:554–63.

    Article  Google Scholar 

  24. Wu JS, Beaton D, Smith PM, Hagen NA. Patterns of pain and interference in patients with painful bone metastases: a brief pain inventory validation study. J Pain Symptom Manage. 2010;39:230–40. https://doi.org/10.1016/j.jpainsymman.2009.07.006.

    Article  PubMed  Google Scholar 

  25. Cheville AL, Murthy NS, Basford JR, Rose PS, Tran K, Pittelkow TP, Ringler MD. Imaging and clinical characteristics predict near-term disablement from bone metastases: Implications for rehabilitation. Arch Phys Med Rehabil. 2016;97:53–60.

    Article  Google Scholar 

  26. •• Galvao DA, Taaffe DR, Spry N, Cormie P, Joseph D, Chambers SK, Chee R, Peddle-Mcintyre CJ, Hart NH, Baumann FT. Exercise preserves physical function in prostate cancer patients with bone metastases. Med Sci Sports Exerc. 2018;50:393. https://doi.org/10.1249/MSS.0000000000001454. This article gives guide to prescribe multimodal exercises in patients with bone metastases.

  27. Dawson JK, Dorff TB, Schroeder ET, Lane CJ, Gross ME, Dieli-Conwright CM. Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial. BMC Cancer. 2018;18:1–15. https://doi.org/10.1186/s12885-018-4306-9.

    Article  CAS  Google Scholar 

  28. Cormie P, Galvão DA, Spry N, Joseph D, Taaffe DR, Newton RU. Functional benefits are sustained after a program of supervised resistance exercise in cancer patients with bone metastases: longitudinal results of a pilot study. Support Care Cancer. 2014;22:1537–48. https://doi.org/10.1007/s00520-013-2103-1.

    Article  PubMed  Google Scholar 

  29. Rief H, Akbar M, Keller M, Omlor G, Welzel T, Bruckner T, Rieken S, Häfner MF, Schlampp I, Gioules A, Debus J. Quality of life and fatigue of patients with spinal bone metastases under combined treatment with resistance training and radiation therapy: a randomized pilot trial. Radiat Oncol. 2014;9:151. https://doi.org/10.1186/1748-717X-9-151.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Rief H, Bruckner T, Schlampp I, Bostel T, Welzel T, Debus J, Förster R. Resistance training concomitant to radiotherapy of spinal bone metastases - survival and prognostic factors of a randomized trial. Radiat Oncol. 2016;11:97. https://doi.org/10.1186/s13014-016-0675-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Rief H, Omlor G, Akbar M, Welzel T, Bruckner T, Rieken S, Haefner MF, Schlampp I, Gioules A, Habermehl D, von Nettelbladt F, Debus J. Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trial. BMC Cancer. 2014;14:67. https://doi.org/10.1186/1471-2407-14-67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Rief H, Petersen LC, Omlor G, Akbar M, Bruckner T, Rieken S, Haefner MF, Schlampp I, Förster R, Debus J, Welzel T. The effect of resistance training during radiotherapy on spinal bone metastases in cancer patients: a randomized trial. Radiother Oncol. 2014;112:133–9. https://doi.org/10.1016/j.radonc.2014.06.008.

    Article  PubMed  Google Scholar 

  33. Rief H, Welzel T, Omlor G, Akbar M, Bruckner T, Rieken S, Haefner MF, Schlampp I, Gioules A, Debus J. Pain response of resistance training of the paravertebral musculature under radiotherapy in patients with spinal bone metastases: a randomized trial. BMC Cancer. 2014;14:485. https://doi.org/10.1186/1471-2407-14-485.

    Article  PubMed  PubMed Central  Google Scholar 

  34. • Sprave T, Rosenberger F, Verma V, Förster R, Bruckner T, Schlampp I, Bostel T, Welzel T, Akbaba S, Rackwitz T, Nicolay NH, Grosu AL, Wiskemann J, Debus J, Rief H. Paravertebral muscle training in patients with unstable spinal metastases receiving palliative radiotherapy: an exploratory randomized feasibility trial. Cancers (Basel). 2019;11:1771. https://doi.org/10.3390/cancers11111771. This study shows that exercise is potentially feasible even in patients with unstable bone metastases.

  35. Delank K-S, Wendtner C, Eich HT, Eysel P. The treatment of spinal metastases. Dtsch Aerzteblatt Int. 2011;108:71. https://doi.org/10.3238/arztebl.2011.0071.

    Article  Google Scholar 

  36. Chang V, Holly LT. Bracing for thoracolumbar fractures. Neurosurg Focus. 2014;37:E3. https://doi.org/10.3171/2014.4.FOCUS1477.

    Article  PubMed  Google Scholar 

  37. Cawley DT, Butler JS, Benton A, Altaf F, Rezajooi K, Kyriakou C, Selvadurai S, Molloy S. Managing the cervical spine in multiple myeloma patients. Hematol Oncol. 2019;37:129–35. https://doi.org/10.1002/hon.2564.

    Article  PubMed  Google Scholar 

  38. Health NIf, Care Excellence. Metastatic spinal cord compression in adults: risk assessment, diagnosis and management: clinical guideline. 2008. https://www.nice.org.uk/guidance/cg75. Accessed 29 Oct 2021.

  39. Lee SH, Grant R, Kennedy C, Kilbride L. Positioning and spinal bracing for pain relief in metastatic spinal cord compression in adults. Cochrane Database Syst Rev. 2015:CD007609. https://doi.org/10.1002/14651858.CD007609.pub3

  40. Newman M, Lowe CM, Barker K. Spinal orthoses for vertebral osteoporosis and osteoporotic vertebral fracture: a systematic review. Arch Phys Med Rehabil. 2016;97:1013–25. https://doi.org/10.1016/j.apmr.2015.10.108.

    Article  PubMed  Google Scholar 

  41. Linhares D, Pinto BS, da Silva MR, Neves N, Fonseca JA. Orthosis in thoracolumbar fractures: a systematic review and meta-analysis of randomized controlled trials. Spine. 2020;45:E1523–31. https://doi.org/10.1097/BRS.0000000000003655.

    Article  PubMed  Google Scholar 

  42. Azadinia F, Ebrahimi ET, Kamyab M, Parnianpour M, Cholewicki J, Maroufi N. Can lumbosacral orthoses cause trunk muscle weakness: a systematic review of literature. Spine J. 2017;17:589–602. https://doi.org/10.1016/j.spinee.2016.12.005.

    Article  PubMed  Google Scholar 

  43. Takasaki H, Miki T. The impact of continuous use of lumbosacral orthoses on trunk motor performance: a systematic review with meta-analysis. Spine J. 2017;17:889–900. https://doi.org/10.1016/j.spinee.2017.03.003.

    Article  PubMed  Google Scholar 

  44. Gwathmey KG. Plexus and peripheral nerve metastasis. Handb Clin Neurol. 2018;149:257–79. https://doi.org/10.1016/B978-0-12-811161-1.00017-7.

    Article  PubMed  Google Scholar 

  45. Mendez JS, DeAngelis LM. Metastatic complications of cancer involving the central and peripheral nervous systems. Neurol Clin. 2018;36:579–98. https://doi.org/10.1016/j.ncl.2018.04.011.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Bollen L, Dijkstra SPD, Bartels R, de Graeff A, Poelma DLH, Brouwer T, Algra PR, Kuijlen JMA, Minnema MC, Nijboer C, Rolf C, Sluis T, Terheggen M, van der Togt-van Leeuwen ACM, van der Linden YM, Taal W. Clinical management of spinal metastases-the Dutch national guideline. Eur J Cancer. 2018;104:81–90. https://doi.org/10.1016/j.ejca.2018.08.028.

    Article  PubMed  Google Scholar 

  47. Wewel JT, O’Toole JE. Epidemiology of spinal cord and column tumors. Neurooncol Pract. 2020;7:i5-9. https://doi.org/10.1093/nop/npaa046.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Ruppert LM. Malignant spinal cord compression. Phys Med Rehabil Clin N Am. 2017;28:101–14. https://doi.org/10.1016/j.pmr.2016.08.007.

    Article  PubMed  PubMed Central  Google Scholar 

  49. • Ruppert LM, Reilly J. Metastatic spine oncology: symptom-directed management. Neurooncol Pract. 2020;7:i54–61. https://doi.org/10.1093/nop/npaa058. This review gives a detailed summary of rehabilitation management of metastatic spinal cord compression based on specific symptomatology.

  50. Gillis TA, Yadav R, Guo Y. Rehabilitation of patients with neurologic tumors and cancer-related central nervous system disabilities. In: Levin VA, editor. Cancer in the nervous system. Oxford: Oxford University Press; 2002.

  51. Escalón MX, Bryce TN. Inpatient rehabilitation of persons with spinal cord injury due to cancer. In: Cristian A, editor. Central nervous system cancer rehabilitation. St Louis: Elsevier; 2019.

  52. Raj VS, Lofton L. Rehabilitation and treatment of spinal cord tumors. J Spinal Cord Med. 2013;36:4–11. https://doi.org/10.1179/2045772312Y.0000000015.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Pataraia A, Crevenna R. Challenges in rehabilitation of patients with nontraumatic spinal cord dysfunction due to tumors: a narrative review. Wien Klin Wochenschr. 2019;131:608–13. https://doi.org/10.1007/s00508-019-1528-z.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Czerniec SA, Ward LC, Meerkin JD, Kilbreath SL. Assessment of segmental arm soft tissue composition in breast cancer-related lymphedema: a pilot study using dual energy X-ray absorptiometry and bioimpedance spectroscopy. Lymphat Res Biol. 2015;13:33–9. https://doi.org/10.1089/lrb.2014.0033.

    Article  PubMed  Google Scholar 

  55. Kirshblum S, O’Dell MW, Ho C, Barr K. Rehabilitation of persons with central nervous system tumors. Cancer. 2001;92:1029–38. https://doi.org/10.1002/1097-0142(20010815)92:4+%3c1029::aid-cncr1416%3e3.0.co;2-p.

    Article  CAS  PubMed  Google Scholar 

  56. Nori P, Kline-Quiroz C, Stubblefield MD. Cancer rehabilitation: acute and chronic issues, nerve injury, radiation sequelae, surgical and chemo-related, part 2. Med Clin North Am. 2020;104:251–62. https://doi.org/10.1016/j.mcna.2019.10.005.

    Article  PubMed  Google Scholar 

  57. New PW, Eriks-Hoogland I, Scivoletto G, Reeves RK, Townson A, Marshall R, Rathore FA. Important clinical rehabilitation principles unique to people with non-traumatic spinal cord dysfunction. Top Spinal Cord Inj Rehabil. 2017;23:299–312. https://doi.org/10.1310/sci2304-299.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Fortin CD, Voth J, Jaglal SB, Craven BC. Inpatient rehabilitation outcomes in patients with malignant spinal cord compression compared to other non-traumatic spinal cord injury: a population based study. J Spinal Cord Med. 2015;38:754–64. https://doi.org/10.1179/2045772314Y.0000000278.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Ikbali Afsar S, Cosar SNS, Yemisci OU, Boluk H. Inpatient rehabilitation outcomes in neoplastic spinal cord compression vs. traumatic spinal cord injury. J Spinal Cord Med. 2020. https://doi.org/10.1080/10790268.2020.1794713

  60. McKinley WO, Huang ME, Tewksbury MA. Neoplastic vs. traumatic spinal cord injury: an inpatient rehabilitation comparison. Am J Phys Med Rehabil. 2000;79:138–44

  61. •• New PW, Simmonds F, Stevermuer T. Comparison of patients managed in specialised spinal rehabilitation units with those managed in non-specialised rehabilitation units. Spinal Cord. 2011;49:909–16. https://doi.org/10.1038/sc.2011.29. This study proposed the NOMPRS framework and practical considerations for managing people with spinal cord dysfunction due to tumors based on consensus opinion from a panel of experts and literature review.

  62. New PW. Understanding the role of rehabilitation medicine in the care of patients with tumor causing spinal cord dysfunction. Curr Phys Med Rehabil Rep. 2017;5:40–5. https://doi.org/10.1007/s40141-017-0142-0.

    Article  Google Scholar 

  63. Stubblefield MD, Bilsky MH. Barriers to rehabilitation of the neurosurgical spine cancer patient. J Surg Oncol. 2007;95:419–26. https://doi.org/10.1002/jso.20783.

    Article  PubMed  Google Scholar 

  64. New PW, Marshall R, Stubblefield MD, Scivoletto G. Rehabilitation of people with spinal cord damage due to tumor: literature review, international survey and practical recommendations for optimizing their rehabilitation. J Spinal Cord Med. 2017;40:213–21. https://doi.org/10.1080/10790268.2016.1173321.

    Article  PubMed  Google Scholar 

  65. Nayar G, Ejikeme T, Chongsathidkiet P, Elsamadicy AA, Blackwell KL, Clarke JM, Lad SP, Fecci PE. Leptomeningeal disease: current diagnostic and therapeutic strategies. Oncotarget. 2017;8:73312–28. https://doi.org/10.18632/oncotarget.20272

  66. Fu JB, Molinares DM, Morishita S, Silver JK, Dibaj SS, Guo Y, Bruera E. Retrospective analysis of acute rehabilitation outcomes of cancer inpatients with leptomeningeal disease. PM R. 2020;12:263–70. https://doi.org/10.1002/pmrj.12207.

    Article  PubMed  Google Scholar 

  67. Wang N, Bertalan MS, Brastianos PK. Leptomeningeal metastasis from systemic cancer: review and update on management. Cancer. 2018;124:21–35. https://doi.org/10.1002/cncr.30911.

    Article  PubMed  Google Scholar 

  68. Le Rhun E, Preusser M, van den Bent M, Andratschke N, Weller M. How we treat patients with leptomeningeal metastases. ESMO Open. 2019;4: e000507. https://doi.org/10.1136/esmoopen-2019-000507.

    Article  PubMed  PubMed Central  Google Scholar 

  69. • Fu JB, Ng AH, Molinares DM, Pingenot EA, Morishita S, Silver JK, Bruera E. Rehabilitation utilization by cancer patients with pathology-confirmed leptomeningeal disease receiving intrathecal chemotherapy. Am J Phys Med Rehabil. 2021;100:100–4. https://doi.org/10.1097/PHM.0000000000001565. This is the first study found to focus on the rehabilitation utilization of patients with leptomeningeal disease.

  70. • Kim J, Jeon JY, Choi YJ, Choi JK, Kim S-B, Jung KH, Ahn J-H, Kim JE, Seo S. Characteristics of metastatic brachial plexopathy in patients with breast cancer. Support Care Cancer. 2020;28:1913–8. https://doi.org/10.1007/s00520-019-04997-6. This study revealed the clinical features of metastatic brachial plexopathy in breast cancer patients that differed from previous reports.

  71. Ibrahim T, Flamini E, Fabbri L, Serra P, Mercatali L, Ricci R, Sacanna E, Falasconi MC, Casadei R, Galassi R. Multidisciplinary approach to the treatment of bone metastases: Osteo-Oncology Center, a new organizational model. Tumori Journal. 2009;95:291–7.

    Article  Google Scholar 

  72. Kimura T. Multidisciplinary approach for bone metastasis: a review. Cancers (Basel). 2018;10:156. https://doi.org/10.3390/cancers10060156.

    Article  CAS  Google Scholar 

  73. Spratt DE, Beeler WH, de Moraes FY, Rhines LD, Gemmete JJ, Chaudhary N, Shultz DB, Smith SR, Berlin A, Dahele M, Slotman BJ, Younge KC, Bilsky M, Park P, Szerlip NJ. An integrated multidisciplinary algorithm for the management of spinal metastases: an international spine oncology consortium report. Lancet Oncol. 2017;18:e720–30. https://doi.org/10.1016/S1470-2045(17)30612-5.

    Article  PubMed  Google Scholar 

  74. Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL. Assessment and management of patients with metastatic spinal cord compression: a multidisciplinary review. J Clin Oncol. 2019;37:61–71. https://doi.org/10.1200/JCO.2018.78.1211.

    Article  CAS  PubMed  Google Scholar 

  75. Nakata E, Sugihara S, Sugawara Y, Nakahara R, Furumatsu T, Tetsunaga T, Kunisada T, Nakanishi K, Akezaki Y, Ozaki T. Multidisciplinary treatment system for bone metastases for early diagnosis, treatment and prevention of malignant spinal cord compression. Oncol Lett. 2020;19:3137–44. https://doi.org/10.3892/ol.2020.11415.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Cheville AL, Tchou J. Barriers to rehabilitation following surgery for primary breast cancer. J Surg Oncol. 2007;95:409–18. https://doi.org/10.1002/jso.20782.

    Article  PubMed  Google Scholar 

  77. Kumar P, Casarett D, Corcoran A, Desai K, Li Q, Chen J, Langer C, Mao JJ. Utilization of supportive and palliative care services among oncology outpatients at one academic cancer center: determinants of use and barriers to access. J Palliat Med. 2012;15:923–30. https://doi.org/10.1089/jpm.2011.0217.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Schiff D, O’Neill BP, Suman VJ. Spinal epidural metastasis as the initial manifestation of malignancy: clinical features and diagnostic approach. Neurology. 1997;49:452–6. https://doi.org/10.1212/wnl.49.2.452.

    Article  CAS  PubMed  Google Scholar 

  79. Schiff D, O’Neill BP. Intramedullary spinal cord metastases: clinical features and treatment outcome. Neurology. 1996;47:906–12. https://doi.org/10.1212/wnl.47.4.906.

    Article  CAS  PubMed  Google Scholar 

  80. Taillibert S, Laigle-Donadey F, Chodkiewicz C, Sanson M, Hoang-Xuan K, Delattre JY. Leptomeningeal metastases from solid malignancy: a review. J Neurooncol. 2005;75:85–99. https://doi.org/10.1007/s11060-004-8101-x.

    Article  PubMed  Google Scholar 

  81. Jaeckle KA. Neurologic manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol. 2010;30:254–62. https://doi.org/10.1055/s-0030-1255219.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all persons who have made substantial contributions to the work reported in the manuscript.

Author information

Authors and Affiliations

Authors

Contributions

All authors whose names appear on the submission made substantial contributions to the article. All authors performed the literature search and analysis. CRB and MNG equally drafted the manuscript and JYJ supervised and critically revised the work. All authors reviewed and commented on the final version of the manuscript.

Corresponding author

Correspondence to Jae Yong Jeon.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Ethics Approval

Not applicable.

Informed Consent

Not applicable.

Consent to Participate

Not applicable.

Consent for Publication

Not applicable.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Cancer Rehabilitation

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bae, C.R., Gelvosa, M.N. & Jeon, J.Y. Rehabilitation in Advanced Cancer Patients with Bone Metastases and Neural Compromise: Current Status and Future Directions. Curr Oncol Rep 24, 1023–1033 (2022). https://doi.org/10.1007/s11912-022-01229-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11912-022-01229-9

Keywords

Navigation