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Mindfulness-Based Interventions and Sleep Among Cancer Survivors: a Critical Analysis of Randomized Controlled Trials

  • Integrative Care (C Lammersfeld, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of review

The purpose of our critical examination is to present results and provide a synthesis of this body of work.

Recent findings

Sleep problems among cancer survivors are gaining research attention. To our knowledge, there have been six randomized control trials published from 2013 to 2015 that test the effects of mindfulness-based interventions (MBIs) on sleep as a primary or secondary outcome.

Summary

Our examination of the literature highlights important methodological issues and variability among trials. We conclude our review by offering solutions to facilitate more scientific rigor in future studies.

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References

Papers of particular interest, published recently, have been highlighted as: ••Of major importance

  1. Piet J, Wurtzen H, Zachariae R. The effect of mindfulness-based therapy on symptoms of anxiety and depression in adult cancer patients and survivors: a systematic review and meta-analysis. J Consult Clin Psychol. 2012;80(6):1007–20.

    Article  PubMed  Google Scholar 

  2. Shennan C, Payne S, Fenlon D. What is the evidence for the use of mindfulness-based interventions in cancer care? Psychooncol. 2011;20(7):681–97.

    Article  Google Scholar 

  3. Ong JC, Ulmer CS, Manber R. Improving sleep with mindfulness and acceptance: a metacognitive model of insomnia. Behav Res Ther. 2012;50(11):651–60.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Black DS, O'Reilly GA, Olmstead R, Breen EC, Irwin MR. Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015;175(4):494–501.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bleiker EM, Pouwer F, van der Ploeg HM, Leer JW, Ader HJ. Psychological distress two years after diagnosis of breast cancer: frequency and prediction. Patient Educ Couns. 2000;40(3):209–17.

    Article  CAS  PubMed  Google Scholar 

  6. Davidson JR, MacLean AW, Brundage MD, Schulze K. Sleep disturbance in cancer patients. Soc Sci Med. 2002;54(9):1309–21.

    Article  PubMed  Google Scholar 

  7. Bower JE, Ganz PA, Irwin MR, Kwan L, Breen EC, Cole SW. Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism? J Clin Oncol. 2011;29(26):3517–22.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Liu L, Mills PJ, Rissling M, Fiorentino L, Natarajan L, Dimsdale JE, et al. Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy. Brain Behav Immun. 2012;26(5):706–13.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rouleau CR, Garland SN, Carlson LE. The impact of mindfulness-based interventions on symptom burden, positive psychological outcomes, and biomarkers in cancer patients. Cancer Manag Res. 2015;7:121–31.

    PubMed  PubMed Central  Google Scholar 

  10. Palesh OG, Roscoe JA, Mustian KM, Roth T, Savard J, Ancoli-Israel S, et al. Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program. J Clin Oncol. 2010;28(2):292–8.

    Article  PubMed  Google Scholar 

  11. Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M. It's not over when it's over: long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med. 2010;40(2):163–81.

    Article  PubMed  Google Scholar 

  12. NIH National Cancer Institute. NCI Dictionary of Cancer Terms [Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms?CdrID=450125].

  13. •• Garland SN, Carlson LE, Stephens AJ, Antle MC, Samuels C, Campbell TS. Mindfulness-based stress reduction compared with cognitive behavioral therapy for the treatment of insomnia comorbid with cancer: a randomized, partially blinded, noninferiority trial. J Clin Oncol. 2014;32(5):449–57. Main focus in our critical examination of RCTs targeting sleep problems. A rigerously executed RCT focusing on sleep as a primary outcome among cancer survivors with a confirmed diagnosis of insomnia, utilizing both ojective and subjective sleep measures.

    Article  PubMed  Google Scholar 

  14. •• Lengacher CA, Reich RR, Paterson CL, Jim HS, Ramesar S, Alinat CB, et al. The effects of mindfulness-based stress reduction on objective and subjective sleep parameters in women with breast cancer: a randomized controlled trial. Psychooncology. 2015;24(4):424–32. Main focus in our critical examination of RCTs targeting sleep problems among cancer survivors. A rigerously executed RCT focusing on sleep as a secondary outcome, utilizing both ojective and subjective sleep measures.

    Article  PubMed  Google Scholar 

  15. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213.

    Article  CAS  PubMed  Google Scholar 

  16. •• Shapiro SL, Bootzin RR, Figueredo AJ, Lopez AM, Schwartz GE. The efficacy of mindfulness-based stress reduction in the treatment of sleep disturbance in women with breast cancer: an exploratory study. J Psychosom Res. 2003;54(1):85–91. Main focus in our critical examination on RCTs targeting sleep problems among cancer survivors. RCT focusing on sleep as a secondary outcome among cancer survivors utilizing subjective measures of sleep.

    Article  PubMed  Google Scholar 

  17. •• Andersen SR, Wurtzen H, Steding-Jessen M, Christensen J, Andersen KK, Flyger H, et al. Effect of mindfulness-based stress reduction on sleep quality: results of a randomized trial among Danish breast cancer patients. Acta Oncol. 2013;52(2):336–44. Main focus in our critical examination of RCTs targeting sleep problems among cancer survivors. RCT focusing on sleep as a secondary outcome among cancer survivors utilizing subjective measures of sleep.

    Article  PubMed  Google Scholar 

  18. •• Bower JE, Crosswell AD, Stanton AL, Crespi CM, Winston D, Arevalo J, et al. Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial. Cancer. 2015;121(8):1231–40. Main focus in our critical examination of RCTs targeting sleep problems among cancer survivors. RCT focusing on sleep as a secondary outcome among cancer survivors utilizing a subjective measure of sleep.

    Article  PubMed  Google Scholar 

  19. •• Johns SA, Brown LF, Beck-Coon K, Monahan PO, Tong Y, Kroenke K. Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors. Psychooncology. 2015;24(8):885–93. Main focus in our critical examination of RCTs targeting sleep problems among cancer survivors. RCT focusing on sleep as a secondary outcome among cancer survivors utilizing a subjective measure of sleep.

    Article  PubMed  Google Scholar 

  20. Gagnon C, Belanger L, Ivers H, Morin CM. Validation of the Insomnia Severity Index in primary care. J Am Board Fam Med. 2013;26(6):701–10.

    Article  PubMed  Google Scholar 

  21. Savard J, Simard S, Blanchet J, Ivers H, Morin CM. Prevalence, clinical characteristics, and risk factors for insomnia in the context of breast cancer. Sleep. 2001;24(5):583–90.

    Article  CAS  PubMed  Google Scholar 

  22. Shapiro SL, Lopez AM, Schwartz GE, Bootzin R, Figueredo AJ, Braden CJ, et al. Quality of life and breast cancer: relationship to psychosocial variables. J Clin Psychol. 2001;57(4):501–19.

    Article  CAS  PubMed  Google Scholar 

  23. Montazeri A, Vahdaninia M, Harirchi I, Ebrahimi M, Khaleghi F, Jarvandi S. Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study. BMC Cancer. 2008;8:330.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Johnsson A, Fornander T, Rutqvist LE, Olsson M. Work status and life changes in the first year after breast cancer diagnosis. Work. 2011;38(4):337–46.

    PubMed  Google Scholar 

  25. Hartl K, Engel J, Herschbach P, Reinecker H, Sommer H, Friese K. Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors. Psychooncology. 2010;19(2):160–9.

    Article  PubMed  Google Scholar 

  26. Kangas M, Henry JL, Bryant RA. The course of psychological disorders in the 1st year after cancer diagnosis. J Consult Clin Psychol. 2005;73(4):763–8.

    Article  PubMed  Google Scholar 

  27. Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP. The role of actigraphy in the study of sleep and circadian rhythms. Sleep. 2003;26(3):342–92.

    Article  PubMed  Google Scholar 

  28. Ong JC, Manber R, Segal Z, Xia Y, Shapiro S, Wyatt JK. A randomized controlled trial of mindfulness meditation for chronic insomnia. Sleep. 2014;37(9):1553–63.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Britton WB, Haynes PL, Fridel KW, Bootzin RR. Mindfulness-based cognitive therapy improves polysomnographic and subjective sleep profiles in antidepressant users with sleep complaints. Psychother Psychosom. 2012;81(5):296–304.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Zeidan F, Emerson NM, Farris SR, Ray JN, Jung Y, McHaffie JG, et al. Mindfulness meditation-based pain relief employs different neural mechanisms than placebo and sham mindfulness meditation-induced analgesia. J Neurosci. 2015;35(46):15307–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Georgia Christodoulou & David S. Black

  2. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

    David S. Black

Authors
  1. Georgia Christodoulou
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  2. David S. Black
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Corresponding author

Correspondence to David S. Black.

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Conflict of Interest

Georgia Christodoulou and David S. Black declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Funding/Support

Funding and resource support was received by a grant from the National Institute on Aging to the USC/UCLA Center on Biodemography and Population Health (P30AG017265), the National Center for Complementary and Integrative Health (L30AT008380), and the American Mindfulness Research Association. The ideas and opinions expressed herein are those of the author(s) and endorsement of those opinions by funders is not intended nor inferred.

Additional information

This article is part of the Topical Collection on Integrative Care

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Christodoulou, G., Black, D.S. Mindfulness-Based Interventions and Sleep Among Cancer Survivors: a Critical Analysis of Randomized Controlled Trials. Curr Oncol Rep 19, 60 (2017). https://doi.org/10.1007/s11912-017-0621-6

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  • DOI: https://doi.org/10.1007/s11912-017-0621-6

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