Skip to main content

Advertisement

Log in

Management of Psychological Complications Following Mild Traumatic Brain Injury

  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

It has been clear for decades that psychological factors often contribute to mild traumatic brain injury (mTBI) outcome, but an emerging literature has begun to clarify which specific factors are important, when, for whom, and how they impact recovery. This review aims to summarize the contemporary evidence on psychological determinants of recovery from mTBI and its implications for clinical management.

Recent Findings

Comorbid mental health disorders and specific illness beliefs and coping behaviors (e.g., fear avoidance) are associated with worse recovery from mTBI. Proactive assessment and intervention for psychological complications can improve clinical outcomes. Evidence-based treatments for primary mental health disorders are likely also effective for treating mental health disorders after mTBI, and can reduce overall post-concussion symptoms. Broad-spectrum cognitive-behavioral therapy may modestly improve post-concussion symptoms, but tailoring delivery to individual psychological risk factors and/or symptoms may improve its efficacy. Addressing psychological factors in treatments delivered primarily by non-psychologists is a promising and cost-effective approach for enhancing clinical management of mTBI.

Summary

Recent literature emphasizes a bio-psycho-socio-ecological framework for understanding mTBI recovery and a precision rehabilitation approach to maximize recovery. Integrating psychological principles into rehabilitation and tailoring interventions to specific risk factors may improve clinical management of mTBI.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Matney C, et al. Understanding patients with traumatic brain injury. In: Traumatic Brain Injury: A Roadmap for Accelerating Progress. US: National Academies Press; 2022.

    Google Scholar 

  2. Van Praag DLG, et al. Post-traumatic stress disorder after civilian traumatic brain injury: a systematic review and meta-analysis of prevalence rates. J Neurotrauma. 2019;36(23):3220–32.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Iljazi A, et al. Post-traumatic stress disorder after traumatic brain injury—a systematic review and meta-analysis. Neurol Sci. 2020;41(10):2737–46.

    Article  PubMed  Google Scholar 

  4. Stein MB, et al. Risk of posttraumatic stress disorder and major depression in civilian patients after mild traumatic brain injury: a TRACK-TBI study. JAMA Psychiat. 2019;76(3):249–58.

    Article  Google Scholar 

  5. van der Vlegel M, et al. The association of post-concussion and post-traumatic stress disorder symptoms with health-related quality of life, health care use and return-to-work after mild traumatic brain injury. J Clin Med. 2021;10(11):2473.

  6. Delmonico RL, et al. Prevalence of depression and anxiety disorders following mild traumatic brain injury. PM R. 2022;14(7):753–63.

    Article  PubMed  Google Scholar 

  7. Costello K, Greenwald BD. Update on domestic violence and traumatic brain injury: a narrative review. Brain Sci. 2022;12(1).

  8. Galovski TE, et al. A multi-method approach to a comprehensive examination of the psychiatric and neurological consequences of intimate partner violence in women: a methodology protocol. Front Psych. 2021;12:569335.

    Article  Google Scholar 

  9. Lamontagne G, et al. Anxiety symptoms and disorders in the first year after sustaining mild traumatic brain injury. Rehabil Psychol. 2022;67(1):90–9.

    Article  PubMed  Google Scholar 

  10. Hellewell SC, et al. Characterizing the risk of depression following mild traumatic brain injury: a meta-analysis of the literature comparing chronic mTBI to non-mTBI populations. Front Neurol. 2020;11:350.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ledoux A-A, et al. Risk of mental health problems in children and youths following concussion. JAMA Netw Open. 2022;5(3):e221235.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wang B, et al. Longitudinal analyses of the reciprocity of depression and anxiety after traumatic brain injury and its clinical implications. J Clin Med. 2021;10(23):5597.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Iverson GL, Greenberg J, Cook NE. Anxiety is associated with diverse physical and cognitive symptoms in youth presenting to a multidisciplinary concussion clinic. Front Neurol. 2022;12:811462.

  14. Terry DP, et al. Effect of depression on cognition after mild traumatic brain injury in adults. Clin Neuropsychol. 2019;33(1):124–36.

    Article  PubMed  Google Scholar 

  15. Zahniser E, et al. The temporal relationship of mental health problems and functional limitations following mTBI: a TRACK-TBI and TED study. J Neurotrauma. 2019;36(11):1786–93.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Durga Roy MDMS, et al. Prevalence and correlates of depressive symptoms within 6 months after first-time mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 34(4):367–377.

  17. Popov N, et al. Factors associated with quality of life in adults with persistent post-concussion symptoms. Can J Neurol Sci. 2022;49(1):109–17.

    Article  PubMed  Google Scholar 

  18. Helmrich IRAR, et al. Development of prognostic models for health-related quality of life following traumatic brain injury. Qual Life Res. 2022;31(2):451–471.

  19. • Maas AI, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022;21(11):1004–1060. This publication reviews insights on TBI (including outcomes after mTBI) from contemporary observational cohorts CENTER-TBI and TRACK-TBI.

  20. Lange RT, Iverson GL, Rose A. Depression strongly influences postconcussion symptom reporting following mild traumatic brain injury. J Head Trauma Rehabil. 2011;26(2):127–37.

    Article  PubMed  Google Scholar 

  21. Wilson L, et al. Tailoring multidimensional outcomes to level of functional recovery after traumatic brain injury. J Neurotrauma. 2022;39(19–20):1363–1381.

  22. Campbell-Sills L, et al. Risk factors for suicidal ideation following mild traumatic brain injury: a TRACK-TBI study. J Head Trauma Rehabil. 2021;36(1):E30–9.

    Article  PubMed  Google Scholar 

  23. Scholten AC, et al. Prevalence of and risk factors for anxiety and depressive disorders after traumatic brain injury: a systematic review. J Neurotrauma. 2016;33(22):1969–94.

    Article  PubMed  Google Scholar 

  24. Silverberg ND, et al. Systematic review of multivariable prognostic models for mild traumatic brain injury. J Neurotrauma. 2015;32(8):517–26.

    Article  PubMed  Google Scholar 

  25. Mikolic A, et al. Prediction of global functional outcome and post-concussive symptoms after mild traumatic brain injury: external validation of prognostic models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study. J Neurotrauma. 2021;38(2):196–209.

    PubMed  Google Scholar 

  26. Mah K, Hickling A, Reed N. Perceptions of mild traumatic brain injury in adults: a scoping review. Disabil Rehabil. 2018;40(8):960–73.

    Article  PubMed  Google Scholar 

  27. Snell DL, et al. Wrestling with uncertainty after mild traumatic brain injury: a mixed methods study. Disabil Rehabil. 2020;42(14):1942–53.

    Article  PubMed  Google Scholar 

  28. Greenberg J, et al. Pain catastrophizing and limiting behavior mediate the association between anxiety and postconcussion symptoms. Psychosomatics. 2020;61(1):49–55.

    Article  PubMed  Google Scholar 

  29. Hou R, et al. When a minor head injury results in enduring symptoms: a prospective investigation of risk factors for postconcussional syndrome after mild traumatic brain injury. J Neurol Neurosurg Psychiatry. 2012;83(2):217–23.

    Article  PubMed  Google Scholar 

  30. van der Naalt J, et al. Early predictors of outcome after mild traumatic brain injury (UPFRONT): an observational cohort study. Lancet Neurol. 2017;16(7):532–40.

    Article  PubMed  Google Scholar 

  31. Silverberg ND, Panenka WJ, Iverson GL. Fear avoidance and clinical outcomes from mild traumatic brain injury. J Neurotrauma. 2018;35(16):1864–73.

    Article  PubMed  Google Scholar 

  32. Cassetta BD, et al. Avoidance and endurance coping after mild traumatic brain injury are associated with disability outcomes. Rehabil Psychol. 2021;66(2):160.

    Article  PubMed  Google Scholar 

  33. Faulkner JW, Snell DL, Theadom A. Psychological flexibility moderates the influence of fear avoidance on outcomes after mild traumatic brain injury. Brain Inj. 2022;36(8):991–999.

  34. Mäki K, et al. Perceived injustice after mild traumatic brain injury. J Head Trauma Rehabil. 2022;37(3):E157–E164.

  35. Battigelli G, Hussain MW. The role of blame attribution in post-concussion syndrome morbidity: a retrospective analysis of patients at a subspecialty clinic. Neurology. 2020;95(20 Supplement 1):S11–2.

    Article  Google Scholar 

  36. Tuborgh A, et al. Attachment and symptom reporting in adolescents and young adults after a concussion. J Psychosom Res. 2021;150:110603.

    Article  CAS  PubMed  Google Scholar 

  37. Fordal L, et al. Trajectories of persistent postconcussion symptoms and factors associated with symptom reporting after mild traumatic brain injury. Arch Phys Med Rehabil. 2022;103(2):313–22.

    Article  PubMed  Google Scholar 

  38. Summerell PA, Smillie LD, Anderson JFI. Personality traits beyond Neuroticism predict post-concussive symptomatology in the post-acute period after mild traumatic brain injury in premorbidly healthy adults. Appl Neuropsychol Adult. 2021:1–10. https://doi.org/10.1080/23279095.2021.1970554.

  39. Caze T, et al. Influence of anxiety sensitivity and negative affect on concussion outcomes. Orthop J Sports Med. 2022;10(5_suppl2):2325967121S00424.

    Article  PubMed Central  Google Scholar 

  40. Picon EL, et al. Memory perfectionism is associated with persistent memory complaints after concussion. Arch Clin Neuropsychol. 2022;37(6):1177–1184.

  41. Elliott TR, et al. Resilience facilitates adjustment through greater psychological flexibility among Iraq/Afghanistan war veterans with and without mild traumatic brain injury. Rehabil Psychol. 2019;64(4):383–97.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Ernst N, et al. Lower post-injury psychological resilience is associated with increased recovery time and symptom burden following sport-related concussion. Appl Neuropsychol Child. 2022;11(4):781–788.

  43. Spikman JM, et al. Coping with stress before and after mild traumatic brain injury: a pilot hair cortisol study. Brain Inj. 2021;35(8):871–9.

    Article  PubMed  Google Scholar 

  44. Parker HA, et al. Personality characteristics and acute symptom response predict chronic symptoms after mild traumatic brain injury. J Int Neuropsychol Soc. 2021;27(10):992–1003.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Reed N, Zemek R. Living guidelines for pediatric concussion care. 2022. Available from:https://pedsconcussion.com/.

    Google Scholar 

  46. Marshall S, Bayley M, McCullagh S, Berrigan L, Fischer L, Ouchterlony D, Rockwell C, Velikonja D, et al. Guideline for concussion/mild traumatic brain injury and persistent symptoms: 3rd edition (for Adults 18+ years of age). Toronto, ON: Ontario Neurotrauma Foundation; 2018. Available at: https://braininjuryguidelines.org/concussion/fileadmin/pdf/Concussion_guideline_3rd_edition_final.pdf. Accessed 20 Sept 2022.

  47. Department of Veterans Affairs and Department of Defense. VA/DoD clinical practice guidelines for the management and rehabilitation of post-acute mild traumatic brain injury. 2021. Available at: https://www.healthquality.va.gov/guidelines/rehab/mtbi/. Accessed 20 Sept 2022

  48. Kroenke K, Spitzer RL. The PHQ-9: a new depression diagnostic and severity measure. Psychiatric Annals. 2002;32(9):509–15.

    Article  Google Scholar 

  49. Spitzer RL, et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092–7.

    Article  PubMed  Google Scholar 

  50. Bovin MJ, et al. Psychometric properties of the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PCL-5) in veterans. Psychol Assess. 2016;28(11):1379–91.

    Article  PubMed  Google Scholar 

  51. Brown RL, Rounds LA. Conjoint screening questionnaires for alcohol and other drug abuse: criterion validity in a primary care practice. Wis Med J. 1995;94(3):135–40.

    CAS  PubMed  Google Scholar 

  52. von Steinbuechel N, et al. Translation and linguistic validation of outcome instruments for traumatic brain injury research and clinical practice: a step-by-step approach within the observational CENTER-TBI study. J Clin Med. 2021;10(13):2863.

    Article  Google Scholar 

  53. Steinbuechel NV, et al. Psychometric characteristics of the patient-reported outcome measures applied in the CENTER-TBI study. J Clin Med. 2021;10(11):2396.

    Article  PubMed  Google Scholar 

  54. Teymoori A, et al. Measurement invariance of assessments of depression (PHQ-9) and anxiety (GAD-7) across sex, strata and linguistic backgrounds in a European-wide sample of patients after Traumatic Brain Injury. J Affect Disord. 2020;262:278–85.

    Article  PubMed  Google Scholar 

  55. Zachar-Tirado CN, Donders J. Clinical utility of the GAD-7 in identifying anxiety disorders after traumatic brain injury. Brain Inj. 2021;35(6):655–60.

    Article  PubMed  Google Scholar 

  56. Donders J, Pendery A. Clinical utility of the Patient Health Questionnaire-9 in the assessment of major depression after broad-spectrum traumatic brain injury. Arch Phys Med Rehabil. 2017;98(12):2514–9.

    Article  PubMed  Google Scholar 

  57. Fann JR, et al. Validity of the Patient Health Questionnaire-9 in assessing depression following traumatic brain injury. J Head Trauma Rehabil. 2005;20(6):501–11.

    Article  PubMed  Google Scholar 

  58. Cook KF, et al. Do somatic and cognitive symptoms of traumatic brain injury confound depression screening? Arch Phys Med Rehabil. 2011;92:818–23.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Teymoori A, et al. Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) scales after traumatic brain injury. J Clin Med. 2020;9(3):873.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Ouellet M-C, et al. Depression in the first year after traumatic brain injury. J Neurotrauma. 2018;35:1620–9.

    Article  PubMed  Google Scholar 

  61. Silverberg ND, et al. Promoting early treatment for mild traumatic brain injury in primary care with a guideline implementation tool: a pilot cluster randomised trial. BMJ Open. 2020;10(10):e035527.

  62. McCarty CA, et al. Collaborative care model for treatment of persistent symptoms after concussion among youth (CARE4PCS-II): study protocol for a randomized, controlled trial. Trials. 2019;20(1):567.

    Article  PubMed  PubMed Central  Google Scholar 

  63. McCrory P, et al. Consensus statement on concussion in sport-the 5(th) international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med. 2017;51(11):838–47.

    PubMed  Google Scholar 

  64. Broadbent E, et al. The brief illness perception questionnaire. J Psychosom Res. 2006;60(6):631–7.

    Article  PubMed  Google Scholar 

  65. Plourde V, et al. Perceptions of symptom duration are associated with emotional distress and functioning in adolescents with protracted concussion recovery. J Pediatr Psychol. 2022.

  66. Moss-Morris R, et al. The revised illness Perception Questionnaire (IPQ-R). Psychol Health. 2002;17(1):1–16.

    Article  Google Scholar 

  67. Snell DL, et al. An examination of the factor structure of the Revised Illness Perception Questionnaire modified for adults with mild traumatic brain injury. Brain Inj. 2010;24(13-14):1595–605.

    Article  PubMed  Google Scholar 

  68. Spence M, Moss-Morris R, Chalder T. The Behavioural Responses to Illness Questionnaire (BRIQ): a new predictive measure of medically unexplained symptoms following acute infection. Psychol Med. 2005;35:583–93.

    Article  PubMed  Google Scholar 

  69. •• Thastum MM, et al. Novel interdisciplinary intervention, GAIN, vs. enhanced usual care to reduce high levels of post-concussion symptoms in adolescents and young adults 2–6 months post-injury: a randomised trial. EClinical Medicine. 2019;17:100214. This randomized trial focused on modifying specific illness-related cognitions and behaviours within an interdisciplinary intervention showed promising results. It also showed that therapists non-psychologists, with input from a neuropsychologist, can successfully address psychological factors.

  70. Snell DL, et al. Evaluation of the fear avoidance behavior after Traumatic Brain Injury Questionnaire. J Neurotrauma. 2020;37(13):1566–73.

    Article  PubMed  Google Scholar 

  71. •• Silverberg ND, et al. Feasibility of concussion rehabilitation approaches tailored to psychological coping styles: a randomized controlled trial. Arch Phys Med Rehabil. 2022;103(8):1565–1573.e2 This trial demonstrates the potential of matching participants to treatment based on their coping styles for improving outcomes.

    Article  PubMed  Google Scholar 

  72. Cairncross M, et al. Normative data for the fear avoidance behavior after Traumatic Brain Injury Questionnaire in a clinical sample of adults with mild TBI. J Head Trauma Rehabil. 2021;36(5):E355–62.

    Article  PubMed  Google Scholar 

  73. Cairncross M, et al. Fear avoidance behavior in youth with poor recovery from concussion: measurement properties and correlates of a new scale. Child Neuropsychol. 2021;27(7):911–21.

    Article  PubMed  Google Scholar 

  74. Stubbs JL, et al. Atypical somatic symptoms in adults with prolonged recovery from mild traumatic brain injury. Front Neurol. 2020;11:43.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Soumoff AA, et al. Somatic symptom severity, not injury severity, predicts probable posttraumatic stress disorder and major depressive disorder in wounded service members. J Trauma Stress. 2022;35(1):210–21.

    Article  PubMed  Google Scholar 

  76. Nelson LD, et al. Preinjury somatization symptoms contribute to clinical recovery after sport-related concussion. Neurology. 2016;86(20):1856–63.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Picon EL, et al. Unexpected symptoms after concussion: potential links to functional neurological and somatic symptom disorders. J Psychosom Res. 2021;151:110661.

    Article  PubMed  Google Scholar 

  78. Iverson GL, et al. “Good old days” bias following mild traumatic brain injury. Clin Neuropsychol. 2010;24(1):17–37.

    Article  PubMed  Google Scholar 

  79. Voormolen DC, et al. Rating of pre-injury symptoms over time in patients with mild traumatic brain injury: the good-old-days bias revisited. Brain Inj. 2020;34(8):1001–9.

    Article  PubMed  Google Scholar 

  80. Yang C-C, et al. “Good-old-days” bias: a prospective follow-up study to examine the preinjury supernormal status in patients with mild traumatic brain injury. J Clin Exp Neuropsychol. 2014;36(4):399–409.

    Article  PubMed  Google Scholar 

  81. Silverberg ND, et al. The nature and clinical significance of preinjury recall bias following mild traumatic brain injury. J Head Trauma Rehabil. 2016;31(6):388–396.

  82. Terpstra AR, et al. Psychological contributions to symptom provocation testing after concussion. J Head Trauma Rehabil. 2022.https://doi.org/10.1097/HTR.0000000000000796.

  83. Van Praag DLG, et al. Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury. Brain Spine. 2022;2:100854.

    Article  PubMed  Google Scholar 

  84. Hromas GA, et al. Making a difference: affective distress explains discrepancy between objective and subjective cognitive functioning after mild traumatic brain injury. J Head Trauma Rehabil. 2021;36(3):186–95.

    Article  PubMed  Google Scholar 

  85. Stenberg J, et al. Change in self-reported cognitive symptoms after mild traumatic brain injury is associated with changes in emotional and somatic symptoms and not changes in cognitive performance. Neuropsychology. 2020;34(5):560–8.

    Article  PubMed  Google Scholar 

  86. Anderson JFI. Cognitive complaint and objective cognition during the post-acute period after mild traumatic brain injury in pre-morbidly healthy adults. Brain Inj. 2021;35(1):103–13.

    Article  PubMed  Google Scholar 

  87. Jurick SM, et al. Prevalence and correlates of self-reported cognitive difficulties in deployment-injured U.S. military personnel. J Trauma Stress. 2022;35(5):1343–1356.

  88. Silverberg ND, et al. Barriers and facilitators to the management of mental health complications after mild traumatic brain injury. Concussion. 2021;6(3):CNC92.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Silverberg ND, et al. Management of concussion and mild traumatic brain injury: a synthesis of practice guidelines. Arch Phys Med Rehabil. 2020;101(2):382–393.

  90. Cook JM, et al. VA residential provider perceptions of dissuading factors to the use of two evidence-based PTSD treatments. Prof Psychol Res Pract. 2014;45(2):136–42.

    Article  Google Scholar 

  91. Silverberg ND, Panenka WJ. Antidepressants for depression after concussion and traumatic brain injury are still best practice. BMC Psychiatry. 2019;19(1):100.

    Article  PubMed  PubMed Central  Google Scholar 

  92. van der Horn HJ, et al. Brain network dysregulation, emotion, and complaints after mild traumatic brain injury. Hum Brain Mapp. 2016;37(4):1645–54.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Medeiros GC, et al. Neuroimaging correlates of depression after traumatic brain injury: a systematic review. J Neurotrauma. 2022;39(11-12):755–72.

    Article  PubMed  Google Scholar 

  94. Mikolić A, et al. Treatment for posttraumatic stress disorder in patients with a history of traumatic brain injury: a systematic review. Clin Psychol Rev. 2019;73:101776.

    Article  PubMed  Google Scholar 

  95. Jak AJ, et al. SMART-CPT for veterans with comorbid post-traumatic stress disorder and history of traumatic brain injury: a randomised controlled trial. J Neurol Neurosurg Psychiatry. 2019;90(3):333–41.

    Article  PubMed  Google Scholar 

  96. McGeary DD, et al. Cognitive behavioral therapy for veterans with comorbid posttraumatic headache and posttraumatic stress disorder symptoms: a randomized clinical trial. JAMA Neurol. 2022;79(8):746–57.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Little A, Byrne C, Coetzer R. The effectiveness of cognitive behaviour therapy for reducing anxiety symptoms following traumatic brain injury: a meta-analysis and systematic review. NeuroRehabilitation. 2021;48(1):67–82.

    Article  PubMed  Google Scholar 

  98. Kreitzer N, et al. The effect of antidepressants on depression after traumatic brain injury: a meta-analysis. J Head Trauma Rehabil. 2019;34(3):E47–54.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Tsai PY, et al. Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis. Sci Rep. 2021;11(1):16940.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. •• Teo SH, et al. Cognitive and psychological interventions for the reduction of post-concussion symptoms in patients with mild traumatic brain injury: a systematic review. Brain Inj. 2020;34(10):1305–21 Review and meta-analysis of psyhological interventions for symptoms after mTBI.

    Article  PubMed  Google Scholar 

  101. •• Chen CL, et al. Effects of cognitive behavioral therapy for adults with post-concussion syndrome: a systematic review and meta-analysis of randomized controlled trials. J Psychosom Res. 2020;136:110190 Review and meta-analysis of cognitive-behavioral therapies for symptoms after mTBI.

    Article  PubMed  Google Scholar 

  102. •• Rytter HM, et al. Nonpharmacological treatment of persistent postconcussion symptoms in adults: a systematic review and meta-analysis and guideline recommendation. JAMA Netw Open. 2021;4(11):e2132221 Review and meta-analysis of nonpharmacological treatments for symptoms after mTBI.

    Article  PubMed  PubMed Central  Google Scholar 

  103. • Sullivan KA, et al. Psychological approaches for the management of persistent postconcussion symptoms after mild traumatic brain injury: a systematic review, in Disability and Rehabilitation. 2020, Disabil Rehabil. p. 2243-2251. Review of psyhological interventions for symptoms after mTBI.

  104. Minen M, Jinich S, Vallespir Ellett G. Behavioral therapies and mind-body interventions for posttraumatic headache and post-concussive symptoms: a systematic review. Headache. 2019;59(2):151–63.

    Article  PubMed  Google Scholar 

  105. Tomfohr-Madsen L, et al. A pilot randomized controlled trial of cognitive-behavioral therapy for insomnia in adolescents with persistent postconcussion symptoms. J Head Trauma Rehabil. 2020;35(2):E103–E112.

  106. Terpstra AR, et al. Psychological mediators of avoidance and endurance behavior after concussion. Rehabil Psychol. 2021;66:470–8.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Gilliam WP, et al. Pain catastrophizing as a treatment process variable in cognitive behavioural therapy for adults with chronic pain. Eur J Pain. 2021;25(2):339–47.

    Article  PubMed  Google Scholar 

  108. Acabchuk RL, et al. Therapeutic effects of meditation, yoga, and mindfulness-based interventions for chronic symptoms of mild traumatic brain injury: a systematic review and meta-analysis. Appl Psychol Health Well Being. 2021;13(1):34–62.

    Article  PubMed  Google Scholar 

  109. Sander AM, et al. A randomized controlled trial of acceptance and commitment therapy for psychological distress among persons with traumatic brain injury. Neuropsychol Rehabil. 2021;31(7):1105–29.

    Article  PubMed  Google Scholar 

  110. Bissell DA, Ziadni MS, Sturgeon JA. Perceived injustice in chronic pain: an examination through the lens of predictive processing. Pain Manag. 2018;8(2):129–38.

    Article  PubMed  PubMed Central  Google Scholar 

  111. Rauwenhoff J, et al. The BrainACT study: acceptance and commitment therapy for depressive and anxiety symptoms following acquired brain injury: study protocol for a randomized controlled trial. Trials. 2019;20(1):773.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Greenberg J, et al. A live video mind-body treatment to prevent persistent symptoms following mild traumatic brain injury: protocol for a mixed methods study. JMIR Res Protoc. 2021;10(1):e25746.

    Article  PubMed  PubMed Central  Google Scholar 

  113. Næss-Schmidt ET, et al. Interdisciplinary intervention (GAIN) for adults with post-concussion symptoms: a study protocol for a stepped-wedge cluster randomised trial. Trials. 2022;23(1):613.

    Article  PubMed  PubMed Central  Google Scholar 

  114. Herdman D, et al. The INVEST trial: a randomised feasibility trial of psychologically informed vestibular rehabilitation versus current gold standard physiotherapy for people with Persistent Postural Perceptual Dizziness. J Neurol. 2022;269(9):4753–63.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Liu TW, et al. Decreasing fear of falling in chronic stroke survivors through cognitive behavior therapy and task-oriented training. Stroke. 2018; https://doi.org/10.1161/STROKEAHA.118.022406.

  116. Clark CN, et al. Reframing postconcussional syndrome as an interface disorder of neurology, psychiatry and psychology. Brain. 2022;145(6):1906–15.

    Article  PubMed  PubMed Central  Google Scholar 

  117. National Academies of Sciences, E. and Medicine, Traumatic Brain Injury: a roadmap for accelerating progress. 2022.

    Google Scholar 

  118. •• Iverson GL. Network analysis and precision rehabilitation for the post-concussion syndrome. Front Neurol. 2019;10:489 This publication reviews the persistent symptoms after mTBI from a network perspective.

    Article  PubMed  PubMed Central  Google Scholar 

  119. van der Horn HJ, et al. An integrated perspective linking physiological and psychological consequences of mild traumatic brain injury. J Neurol. 2020;267(9):2497–506.

    Article  PubMed  Google Scholar 

  120. Silverberg ND, Iverson GL. Etiology of the post-concussion syndrome: physiogenesis and psychogenesis revisited. NeuroRehabilitation. 2011;29(4):317–29.

    Article  PubMed  Google Scholar 

  121. Fink P, et al. Symptoms and syndromes of bodily distress: an exploratory study of 978 internal medical, neurological, and primary care patients. Psychosom Med. 2007;69(1):30–9.

    Article  PubMed  Google Scholar 

  122. Green K, et al. History of functional somatic syndromes and persistent symptoms after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2021;33(2):109–15.

    Article  PubMed  Google Scholar 

  123. Vuu S, et al. Physical exercise for people with mild traumatic brain injury: a systematic review of randomized controlled trials. NeuroRehabilitation. 2022;51(2):185–200.

  124. Leddy JJ, et al. Early targeted heart rate aerobic exercise versus placebo stretching for sport-related concussion in adolescents: a randomised controlled trial. Lancet Child Adolesc Health. 2021;5(11):792–9.

    Article  PubMed  Google Scholar 

  125. Chrisman SPD, et al. Pilot randomized controlled trial of an exercise program requiring minimal in-person visits for youth with persistent sport-related concussion. Front Neurol. 2019;10:623.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Wijenberg M, et al. Do fear and catastrophizing about mental activities relate to fear-avoidance behavior in a community sample? An experimental study. J Clin Exp Neuropsychol. 2021;43(1):66–77.

    Article  PubMed  Google Scholar 

  127. Ashar YK, et al. Effect of pain reprocessing therapy vs placebo and usual care for patients with chronic back pain: a randomized clinical trial. JAMA Psychiat. 2022;79(1):13–23.

    Article  Google Scholar 

  128. Jungilligens J, et al. A new science of emotion: implications for functional neurological disorder. Brain. 2022;145(8):2648–63.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Mollica A, et al. Neuromodulation treatments for mild traumatic brain injury and post-concussive symptoms. Curr Neurol Neurosci Rep. 2022;22(3):171–81.

    Article  PubMed  Google Scholar 

  130. Vlaeyen JWS, et al. Towards a dynamic account of chronic pain. Pain. 2022;163(9):e1038–e1039.

  131. Price M, et al. The symptoms at the center: examining the comorbidity of posttraumatic stress disorder, generalized anxiety disorder, and depression with network analysis. J Psychiatr Res. 2019;109:52–8.

    Article  PubMed  Google Scholar 

  132. Afzali MH, et al. A network approach to the comorbidity between posttraumatic stress disorder and major depressive disorder: the role of overlapping symptoms. J Affect Disord. 2017;208:490–6.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Noah D. Silverberg.

Ethics declarations

Conflict of Interest

No competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Silverberg, N.D., Mikolić, A. Management of Psychological Complications Following Mild Traumatic Brain Injury. Curr Neurol Neurosci Rep 23, 49–58 (2023). https://doi.org/10.1007/s11910-023-01251-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11910-023-01251-9

Keywords

Navigation