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Cancer and Cerebrovascular Disease

  • Neurology of Systemic Diseases (J. Biller, Section Editor)
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To review the latest information about the interactions between cancer and cerebrovascular disease.

Recent Findings

Additional data support the finding that both ischemic and hemorrhagic stroke are important complications of cancer or its treatment. Reperfusion therapy is being given successfully to patients with stroke complicating cancer.

Summary

Hemorrhagic stroke may occur with metastatic disease to the brain, coagulopathies from cancer, in particular leukemia, or as complications of chemotherapy. Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro-thrombotic disorder such as non-bacterial thrombotic endocarditis (NBTE) or disseminated intravascular coagulation (DIC), or secondary to chemotherapy. Stroke also is a potential consequence of radiation therapy to the head and neck. Venous sinus thrombosis may develop with hematologic malignancies or chemotherapy. Although many patients will have a history of cancer at the time of stroke, a cerebrovascular event may be the initial manifestation of a malignancy.

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  1. Division of Cerebrovascular Diseases, Department of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Harold P. Adams Jr

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Adams, H.P. Cancer and Cerebrovascular Disease. Curr Neurol Neurosci Rep 19, 73 (2019). https://doi.org/10.1007/s11910-019-0985-0

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