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Disturbances of Sleep and Alertness in Parkinson’s Disease

  • Movement Disorders (S Fox, Section Editor)
  • Published:
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Abstract

Purpose of Review

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest over the past two decades due to its impact on the daily lives of PD patients, poorly understood mechanisms, and limited treatment options. In this review, we discuss the most common sleep disorders in PD and present recent investigations that have broadened our understanding of the epidemiology, clinical manifestations, diagnosis, and treatment of disturbed sleep and alertness in PD.

Resent Findings

The etiology of impaired sleep-wake cycles in PD is multifactorial. Sleep dysfunction in PD encompasses insomnia, REM sleep behavior disorder, sleep-disordered breathing, restless legs syndrome, and circadian dysregulation. Despite the high prevalence of sleep dysfunction in PD, evidence supporting the efficacy of treatment strategies is limited.

Summary

We are at the opportune time to advance our understanding of sleep dysfunction in PD, which will hopefully lead to mechanisms-driven interventions for better sleep and allow us to approach sleep as a modifiable therapeutic target for other non-motor and motor manifestations in PD.

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Authors and Affiliations

  1. Movement Disorders Unit, Massachusetts General Hospital, Boston, MA, 02114, USA

    Aleksandar Videnovic

  2. Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA

    Aleksandar Videnovic

  3. MGH Neurological Clinical Research Institute, 165 Cambridge Street, Suite 600, Boston, MA, 02446, USA

    Aleksandar Videnovic

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Aleksandar Videnovic reports a grant from the National Institutes of Health (#R01NS099055 02).

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Videnovic, A. Disturbances of Sleep and Alertness in Parkinson’s Disease. Curr Neurol Neurosci Rep 18, 29 (2018). https://doi.org/10.1007/s11910-018-0838-2

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