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Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults

  • Sleep (M Thorpy and M Billiard, Section Editors)
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Abstract

Purpose of Review

This article reviews the neurobehavioral deficits resulting from sleep loss in adults, various countermeasures to mitigate these effects, and biomarkers to identify individual differences in neurobehavioral responses.

Recent Findings

Total sleep deprivation and chronic sleep restriction increase the homeostatic sleep drive and diminish waking neurobehavioral functioning, producing deficits in attention, memory and cognitive speed, increases in sleepiness and fatigue, and unstable wakefulness. Recovery sleep, extension of sleep, and use of caffeine and/or naps are all effective countermeasures to mitigate these responses. Candidate gene and various “omics” approaches have identified biomarkers that may predict such responses.

Summary

Sleep loss is increasingly prevalent and produces reliable, differential neurobehavioral deficits across individuals. Recent research has identified biomarkers to predict these responses, though future work is warranted, such that precise determination of who will develop neurobehavioral decrements from sleep loss will be possible.

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Acknowledgments

Preparation of this manuscript was supported by National Aeronautics and Space Administration NNX14AN49G (to NG).

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  1. Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 1017 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA

    Namni Goel

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All reported studies/experiments with human subjects performed by the author have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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Goel, N. Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults. Curr Neurol Neurosci Rep 17, 89 (2017). https://doi.org/10.1007/s11910-017-0799-x

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