Skip to main content
SpringerLink
Log in

Rebuilding for Tomorrow’s Outbreak: The State of Special Pathogen Preparedness in the USA in the Wake of COVID-19

  • Healthcare Associated Infections (ME Doll and B Rittmann, Section Editors)
  • Published:
Current Infectious Disease Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Special pathogens require unique planning care capabilities within healthcare facilities and can pose significant public health threats. Outbreaks have continued to emerge through the COVID-19 pandemic and serve as reminders of the need to have tiered levels of readiness and resources supporting all healthcare settings.

Recent Findings

Recent outbreaks of Marburg virus, Sudan virus, Lassa virus, and Nipah virus are examples of low-incidence pathogens that carry disproportionally high potential consequences for healthcare worker safety and public health. While the COVID-19 pandemic has increased awareness of the potential impacts of emerging infectious diseases on communities, it has also introduced new challenges in hospital special pathogen preparations, including high staff turnover, high patient volumes, fatigue, and financial challenges.

Summary

All healthcare organizations must act to ensure they can promptly identify suspected special pathogen patients using the “identify, isolate, inform” paradigm. A subset of healthcare facilities networked across the nation must have higher level special pathogen capabilities to ensure access to high quality and safe care is available to all. Preparing for special pathogens involves use of non-traditional personal protective equipment (PPE), specialized PPE doffing protocols, and complex resources and protocols supporting laboratory testing and waste management. Because of known and persistent gaps in special pathogen readiness, the US healthcare system continues to invest in the development of the National Special Pathogens System supported by the Administration for Strategic Preparedness and Response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Availability of Data and Materials

Not applicable.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Centers for Disease Control and Prevention. Interim guidance for U.S. hospital preparedness for patients under investigation (PUIs) or with confirmed Ebola virus disease (EVD): a framework for a tiered approach. 2022. https://www.cdc.gov/vhf/ebola/healthcare-us/preparing/hospitals.html. Accessed 2 Aug 2023. A framework for health departments and acute care settings in developing preparedness plans for Ebola virus disease and Marburg virus disease.

  2. World Health Organization. Ghana declares first-ever outbreak of Marburg virus disease. 2022.  https://www.afro.who.int/countries/ghana/news/ghana-declares-first-ever-outbreak-marburg-virus-disease-. Accessed 2 Aug 2023.

  3. Centers for Disease Control and Prevention. Marburg virus disease outbreaks. 2023. https://www.cdc.gov/vhf/marburg/outbreaks/chronology.html. Accessed 2 Aug 2023.

  4. Centers for Disease Control and Prevention. Uganda Ebola outbreak. 2023. https://www.cdc.gov/vhf/ebola/outbreaks/uganda/2022-sep.html. Accessed 2 Aug 2023.

  5. Magassouba, N. Marburg virus sequence from Guinea, 2021. 2021. https://virological.org/t/marburg-virus-sequence-from-guinea-2021/755. Accessed 2 Aug 2023.

  6. Schnirring, L. Tanzania declares Marburg virus outbreak. 2023. https://www.cidrap.umn.edu/marburg/tanzania-declares-marburg-virus-outbreak. Accessed 2 Aug 2023.

  7. Bonney, JHK, Santers, T, Adams, P, Adu, B, Asante, IA, Bonney, EY, et al. First-ever outbreak of Marburg virus declared in Ghana. 2022. https://virological.org/t/first-ever-outbreak-of-marburg-virus-disease-declared-in-ghana-2022/897. Accessed 2 Aug 2023.

  8. World Health Organization. Ebola disease caused by Sudan ebolavirus-Uganda. 2023. https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON433#:~:text=Uganda%20declared%20an%20outbreak%20of,Virus%20Research%20Institute%20(UVRI). Accessed 2 Aug 2023.

  9. Kanyerezi, S. Preliminary analysis of selected Sudan Ebola virus isolates from the 2022 Uganda outbreak. 2023. https://virological.org/t/preliminary-analysis-of-selected-sudan-ebola-virus-isolates-from-the-2022-uganda-outbreak/919. Accessed 2 Aug 2023.

  10. World Health Organization. Lassa fever. 2022. https://www.who.int/health-topics/lassa-fever#tab=tab_1. Accessed 2 Aug 2023.

  11. UK Health Security Agency. Lassa fever cases identified in England, following travel to West Africa. 2022. https://www.gov.uk/government/news/lassa-fever-cases-identified-in-england-following-travel-to-west-africa-1 . Accessed 2 Aug 2023.

  12. Pillai VS, Krishna G, Veettil MV. Nipah virus: past outbreaks and future containment. Viruses. 2022. https://doi.org/10.3390/v12040465.

    Article  Google Scholar 

  13. Centers for Disease Control. Nipah virus (NiV). 2022. https://www.cdc.gov/vhf/nipah/index.html. Accessed 02 Aug 2023.

  14. World Health Organization. Nipah virus infection-Bangladesh. 2023. https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON442#. Accessed 2 Aug 2023.

  15. UK Health Security Agency. Monkeypox cases confirmed in England-latest updates. 2022. https://www.gov.uk/government/news/monkeypox-cases-confirmed-in-england-latest-updates. Accessed 2 Aug 2023.

  16. Centers for Disease Control and Prevention. 2022 Mpox Outbreak Global Map. 2023. https://www.cdc.gov/poxvirus/mpox/response/2022/world-map.html. Accessed 2 Aug 2023.

  17. Martinez JI, Montalban EG, Bueno SJ, Martinez FM, Julia AN, Diaz JS, et al. Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022. Eurosurveillance. 2022. https://doi.org/10.2807/1560-7917.ES.2022.27.27.2200471.

    Article  PubMed  PubMed Central  Google Scholar 

  18. • Centers for Disease Control and Prevention. Guidance on personal protective equipment (PPE) to be used by healthcare workers during management of patients with confirmed Ebola or persons under investigation (PUIs) for Ebola who are clinically unstable or have bleeding, vomiting, or diarrhea in U.S. healthcare settings, including procedures for donning and doffing PPE. 2022. https://www.cdc.gov/vhf/ebola/healthcare-us/ppe/guidance.html. Accessed 4 Aug 2023. Guidance on the best practices concerning confirmed Ebola patients or clinically unstable PUIs.

  19. Moosavi J, Fathollahi-Fard AM, Dulebenets MA. Supply chain disruption during the COVID-19 pandemic: recognizing potential disruption management strategies. International Journal of Disaster Risk Reduction. 2022. https://doi.org/10.1016/j.ijdrr.2022.102983.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Healthcare Ready and ASPR TRACIE. Disaster available supplies in hospitals. 2023. https://dashtool.org/. Accessed 4 Aug 2023.

  21. Centers for Disease Control and Prevention. For U.S. healthcare settings: donning and doffing personal protective equipment (PPE) for evaluating persons under investigation (PUIs) for Ebola who are clinically stable and do not have bleeding, vomiting, or diarrhea. 2022. https://www.cdc.gov/vhf/ebola/healthcare-us/ppe/guidance-clinically-stable-puis.html. Accessed 4 Aug 2023.

  22. • Osei-Bonsu K, Masroor N, Cooper K, Doern C, Jefferson KK, Major Y, et al. Alternative doffing strategies of personal protective equipment to prevent self-contamination in the health care setting. Am J Infect Control. 2019. https://doi.org/10.1016/j.ajic.2018.11.003. This article emphasizes that close attention to doffing technique is necessary for optimal reduction to the risk of self-contamination while doffing PPE.

    Article  PubMed  Google Scholar 

  23. Tomas ME, Kundrapu S, Thota P, Sunkesula VCK, Cadnum JL, Mana TSC, et al. Contamination of healthcare personnel during removal of personal protective equipment. JAMA Intern Med. 2015. https://doi.org/10.1001/jamainternmed.2015.4535.

    Article  PubMed  Google Scholar 

  24. Suen LKP, Guo YP, Tong DWK, Leung PHM, Lung D, Ng MSP, et al. Self-contamination during doffing of personal protective equipment by healthcare workers to prevent Ebola transmission. Antimicrob Resist Infect Control. 2018. https://doi.org/10.1186/s13756-018-0433-y.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Lim, SM, Chua, WC, Chae, MK, Jo IJ. Contamination during doffing of personal protective equipment by healthcare providers. Clin Exp Emerg Med. 2015. https://doi.org/10.15441/ceem.15.019

  26. McClaws ML, Chughtai AA, Salmon S, MacIntyre CR. A highly precautionary doffing sequence for health care workers after caring for wet Ebola patients to further reduce occupational acquisition of Ebola. Am J Infect Control. 2016. https://doi.org/10.1016/j.ajic.2015.12.034.

    Article  Google Scholar 

  27. Occupational Safety and Health Administration. Ebola. https://www.osha.gov/ebola/control-prevention. Accessed 4 Aug 2023.

  28. Casnova LM, Erukunuakpor K, Kraft CS, Mumma JM, Durso FT, Ferguson AN, et al. Assessing viral transfer during doffing of Ebola-level personal protective equipment in a biocontainment unit. Clin Infect Dis. 2018. https://doi.org/10.1093/cid.cix956.

    Article  Google Scholar 

  29. Centers for Disease Control and Prevention. Trained observer for all PPE. 2019. https://www.cdc.gov/vhf/ebola/hcp/ppe-training/trained-observer/observer_01.html. Accessed 4 Aug 2023.

  30. U.S. Department of Transportation. Transporting infectious substances. 2022. https://www.phmsa.dot.gov/transporting-infectious-substances/transporting-infectious-substances-overview. Accessed 4 Aug 2023.

  31. • U.S. Department of Transportation. Managing solid waste contaminated with a category A infectious substance. 2022. https://www.phmsa.dot.gov/sites/phmsa.dot.gov/files/2022-06/Cat%20A%20Waste%20Planning%20Guidance_Final_2022_06.pdf. Accessed 4 Aug 2023. A robust overview and planning guidance on the safe handling of category A waste.

  32. Occupational Health and Safety Administration. Safe handling, treatment, transport and disposal of Ebola-contaminated waste. 2016. https://www.osha.gov/sites/default/files/publications/OSHA_FS-3766.pdf. Accessed 4 Aug 2023.

  33. Lowe JJ, Gibbs SG, Schwedhelm SS, Nguyen J, Smith PW. Nebraska biocontainment unit perspective on disposal of Ebola medical waste. American Journal of Infection Control. 2014. https://doi.org/10.1093/cid/ciw256

  34. Centers for Disease Control and Prevention. Ebola disease. 2023 https://www.cdc.gov/vhf/ebola/clinicians/evd/infection-control.html. Accessed 4 Aug 2023.

  35. O’Keefe AL, Buss BF, Koirala S, Gleason MX, Mudgapalli A, Schwedhelm S. REDCap for biocontainment worker symptom monitoring. Health Security. 2019. https://doi.org/10.1089/hs.2018.0086.

    Article  PubMed  Google Scholar 

  36. Wong KK, Davey RT Jr, Hewlett AL, Kraft CS, Mehta AK, Mulligan MJ, et al. Use of postexposure prophylaxis after occupational exposure to Zaire ebolavirus. Clinical Infectious Disease. 2016. https://doi.org/10.1093/cid/ciw256.

    Article  Google Scholar 

  37. Fairley JK, Kozarsky PE, Kraft CS, Guarner J, Steinberg JP, Anderson E, et al. Ebola or not? Evaluating the ill traveler from Ebola-affected countries in West Africa. Open Forum Infect Dis. 2016. https://doi.org/10.1093/ofid/ofw005.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Boggild AK, Esposito DH, Kozarsky PE, Ansdell V, Beeching NJ, Campion D, et al. Differential diagnosis of illness in travelers arriving from Sierra Leone, Liberia, or Guinea: a cross-sectional study from the GeoSentinel Surveillance Network. Ann Intern Med. 2015. https://doi.org/10.7326/M15-0074.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Tan KR, Cullen KA, Koumans EH, Arguin PM. Inadequate diagnosis and treatment of malaria among travelers returning from Africa during the Ebola epidemic--United States, 2014–2015. Morbidity and Mortality Weekly Report. 2016. https://doi.org/10.15585/mmwr.mm6502a3

  40. Centers for Disease Control and Prevention. LRN-B enables a rapid laboratory response to biological threats. 2019. https://emergency.cdc.gov/lrn/lrnbfactsheet.asp. Accessed 2 Aug 2023.

  41. Centers for Disease Control and Prevention. Guidance for U.S. hospitals and clinical laboratories on performing routine diagnostic testing for patients with suspected Ebola disease. 2023. https://www.cdc.gov/vhf/ebola/laboratory-personnel/safe-specimen-management.html. Accessed 7 Aug. 2023.

  42. Occupational Health and Safety Administration. Bloodborne pathogens Standard. 2019. https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1030. Accessed 7 Aug. 2023.

  43. Grein JD, Murthy AR. Preparing a hospital for Ebola virus disease: a review of lessons learned. Curr Treat Options Infect Dis. 2016. https://doi.org/10.1007/s40506-016-0087-3.

    Article  Google Scholar 

  44. McMahon SA, Ho LS, Brown H, Miller L, Ansumana R, Kennedy CE. Healthcare providers on the frontlines: a qualitative investigation of the social and emotional impact of delivering health services during Sierra Leone’s Ebola epidemic. Health Policy Plan. 2016. https://doi.org/10.1093/heapol/czw055.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Zaçe D, Hoxhaj I, Orfino A, Viteritti AM, Janiri L, Di Pietro ML. Interventions to address mental health issues in healthcare workers during infectious disease outbreaks: a systematic review. J Psychiatr Res. 2021. https://doi.org/10.1016/j.jpsychires.2021.02.019.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Kraft CS, Kortepeter MG, Gordon B, Sauer LM, Shenoy ES, Eiras DP, et al. The Special Pathogens Research Network: enabling research readiness. Health Security. 2019. https://doi.org/10.1089/hs.2018.0106.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Lowe AE, Kraft C, Kortepeter MG, Hansen KF, Sanger K, Johnson A, et al. Developing a rapid response single IRB model for conducting research during a public health emergency. Health Security. 2022. https://doi.org/10.1089/hs.2021.0181.

    Article  PubMed  Google Scholar 

  48. Tetteh HA. A leader’s guide to crisis communication: lessons from Ebola for COVID-19. Mil Med. 2020. https://doi.org/10.1093/milmed/usaa158.

    Article  PubMed  Google Scholar 

  49. • Centers for Disease Control and Prevention. Identify, isolate, inform: emergency department evaluation and management for patients under investigation (PUIS) for Ebola virus disease (EVD). 2022. https://www.cdc.gov/vhf/ebola/clinicians/emergency-services/emergency-departments.html. Accessed 2 Aug 2023. A framework for emergency department staff to utilize the identify, isolate, and inform model for patients with a suspected special pathogen.

  50. Reeves J, Hollandsworth HM, Torriani FJ, Taplitz R, Abeles S, Tai-Seale M, et al. Rapid response to COVID-19: health informatics support for outbreak management in an academic health system. J Am Med Inform Assoc. 2020. https://doi.org/10.1093/jamia/ocaa037.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Sauer LM, Romig R, Andonian J, Flinn JB, Hynes NA, et al. Application of the incident command system to the hospital biocontainment unit setting. Health Security. 2019. https://doi.org/10.1089/hs.2019.0006.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Borromeo Flinn J, Benza JJ, Sauer LM, Sulmonte C, Hynes NA, Garibaldi BT. The risk of not being ready: a novel approach to managing constant readiness of a high-level isolation unit during times of inactivity. Health Security. 2020. https://doi.org/10.1089/hs.2019.0130Abiocontainmentunit’sself-assessmentformaintainingreadinesstocareforpatientswithspecialpathogens.

    Article  PubMed  Google Scholar 

  53. • Farmer, P. Fevers, feuds, and diamonds: Ebola and the ravages of history. Farrar, Straus, and Giroux. 2020. A retrospective on the lessons learned from the West African Ebola outbreak (2014–2016) to help shape future response.

    Google Scholar 

  54. Kogutt BK, Sheffield JS, Whyne D, Maragakis LL, Andonian J, Flinn J, Sulmonte C, et al. Simulation of a spontaneous vaginal delivery and neonatal resuscitation in a biocontainment unit. Health Security. 2019. https://doi.org/10.1089/hs.2018.0090.

    Article  PubMed  PubMed Central  Google Scholar 

  55. NSI. 2023 National Health Care Retention & RN Staffing Report. 2023. https://www.nsinursingsolutions.com/Documents/Library/NSI_National_Health_Care_Retention_Report.pdf. Accessed 02 Aug 2023.

  56. International Council of Nurses. The global nursing shortage and nurse retention. 2023. https://www.icn.ch/sites/default/files/inline-files/ICN%20Policy%20Brief_Nurse%20Shortage%20and%20Retention_0.pdf. Accessed 02 Aug 2023.

  57. Northington WE, Mahoney GM, Hahn ME, Suyama J, Hostler D. Training and retention of level C personal protective equipment use by emergency medical services personnel. Acad Emerg Med. 2007. https://doi.org/10.1197/j.aem.2007.06.034.

    Article  PubMed  Google Scholar 

  58. Billman CL, Flinn J, Gadala A, Bowman C, McIlquham T, Sulmonte CJ, Garibaldi BT. Creating a safety officer program to enhance staff safety during the care of COVID-19 patients. Health Security. 2020. https://doi.org/10.1089/hs.2021.0182.

    Article  Google Scholar 

  59. •• Grein JD, Garland JA, Arguinchona C, Frank MG, Garibaldi BT, Grindle A, Hewlett A, Kline S, Levine CB, Mehta A, Mukherjee V, Sauer LM, Searle EF, Vanairsdale S, Vasa A. Contributions of the regional emerging special pathogen treatment centers to the US COVID-19 pandemic response. Health Security. 2020. https://doi.org/10.1089/hs.2021.0188. Describes the value of ongoing special pathogen preparedness leading up to the COVID-19 pandemic.

    Article  Google Scholar 

  60. Levine CB, Vasistha S, Persson CC, Larson LR, Kratochvil CJ, Mehta A, Hicks LJ, Lowe AE, Kortepeter MG, Sauer LM. Prepared to act: lessons learned by the special pathogens research network based on collaborations with the NIAID-led adaptive COVID-19 treatment trial. Health Security. 2020. https://doi.org/10.1089/hs.2021.0178.

    Article  Google Scholar 

  61. Vasa A, Pacino V, Vasistha S, ElRayes W, Lowe JJ. COVID-19 response among US hospitals with emerging special pathogens programs. Health Security. 2020. https://doi.org/10.1089/hs.2021.0193.

    Article  Google Scholar 

  62. Joint Commission. Comment on proposed new infection control requirements for hospitals, critical access hospitals. https://www.jointcommission.org/resources/news-and-multimedia/newsletters/newsletters/joint-commission-online/may-24-2023/comment-on-proposed-new-infection-control-requirements-for-hap-cah/ . Accessed 02 Aug 2023

  63. Kratochvil CJ, Evans L, Ribner BS, Lowe JJ, Harvey MC, Hunt RC, et al. The National Ebola Training and Education Center: preparing the United States for Ebola and other special pathogens. Health Security. 2017. https://doi.org/10.1089/hs.2017.0005.

    Article  PubMed  Google Scholar 

  64. • Mukherjee V, Sauer LM, Mehta AK, Shea SY, Biddinger PD, Carr BG, et al. The evolution of the national special pathogen system of care. Health Security. 2022. https://doi.org/10.1089/hs.2022.0026. A description of a national, structured plan to address the current state of the healthcare system and public and private partners to develop an effective and equitable special pathogens system of care.

    Article  PubMed  Google Scholar 

  65. International Air Transport Association. Air passenger numbers to recover in 2024. https://www.iata.org/en/pressroom/2022-releases/2022-03-01-01/. Accessed 04 Aug 2023.

  66. Debnath F, Chakraborty D, Deb AK, Saha MK, Dutta S. Increased human-animal interface & emerging zoonotic diseases: an enigma requiring multi-sectoral efforts to address. Indian J Med Res. 2021. https://doi.org/10.4103/ijmr.IJMR_2971_20.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biocontainment Unit, Johns Hopkins Special Pathogens Center, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD, 21287, USA

    Jade B. Flinn

  2. Virginia Commonwealth University, Richmond, VA, USA

    Amy D. Britton

  3. Special Pathogens Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Jennifer Garland & Jennifer Cuzzolina

  4. Center for Disaster Medicine, Massachusetts General Hospital, Boston, MA, USA

    Paul D. Biddinger

  5. Special Pathogens Program, Bellevue Hospital, Bellevue, NY, USA

    Vikramjit Mukherjee

  6. Department of Hospital Epidemiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Jonathan D. Grein

Authors
  1. Jade B. Flinn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amy D. Britton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jennifer Garland
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jennifer Cuzzolina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paul D. Biddinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Vikramjit Mukherjee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jonathan D. Grein
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

J.F., A.B., J.G., J.C., and J.D.G. conceived the idea and outline of the article, performed literature review, and drafted the initial manuscript. J.F. provided edits and finalized the manuscript. P.B. and V.M. critically reviewed the work and provided feedback. All authors reviewed the final manuscript.

Corresponding author

Correspondence to Jade B. Flinn.

Ethics declarations

Ethical Approval

This article does not contain any studies with human or animal subjects performed by any of the authors.

Competing Interests

The authors Jade Flinn, Jennifer Garland, Jennifer Cuzzolina, Paul Biddinger, Vikramjit Mukherjee, and Jonathan Grein receive salary support through the Administration for Strategic Preparedness and Response (ASPR) grant “Regional Ebola and Other Special Pathogen Treatment Centers.” This is a federal grant that supports the National Emerging Special Pathogens Treatment Education Center (NETEC) and the Regional Special Pathogens Treatment Center (RESPTC) programs.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Flinn, J.B., Britton, A.D., Garland, J. et al. Rebuilding for Tomorrow’s Outbreak: The State of Special Pathogen Preparedness in the USA in the Wake of COVID-19. Curr Infect Dis Rep 25, 313–322 (2023). https://doi.org/10.1007/s11908-023-00821-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11908-023-00821-9

Keywords

Search

Navigation