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Candida parapsilosis Vaginal Infection—a New Site of Azole Drug Resistance

  • Female Genital Tract Infections (J Sobel, Section Editor)
  • Published:
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Abstract

Purpose of Review

Evaluation of pathogenicity of an uncommon vaginal Candida species, Candida parapsilosis with particular references to susceptibility to conventional antifungal agents.

Recent Findings

C. parapsilosis vaginal isolates usually present in asymptomatic women as commensals but may induce vulvovaginal symptoms indistinguishable from C. albicans requiring antifungal therapy; however, recent experience reveals clinically relevant resistance to the azole class of antimycotics.

Conclusion

Clinicians are required to determine a causal relationship between vaginal isolates of C. parapsilosis before prescribing antifungal agents, recognizing the possibility of fluconazole resistance to explain refractory symptomatology.

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Authors and Affiliations

  1. Division of Infectious Diseases, Wayne State University School of Medicine, 540 E. Canfield St., 1241 Scott Hall, Detroit, MI, 48201, USA

    J. D. Sobel & S. Suprapaneni

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  1. J. D. Sobel
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  2. S. Suprapaneni
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Correspondence to J. D. Sobel.

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J. D. Sobel and S. Suprapaneni declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Female Genital Tract Infections

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Sobel, J.D., Suprapaneni, S. Candida parapsilosis Vaginal Infection—a New Site of Azole Drug Resistance. Curr Infect Dis Rep 20, 43 (2018). https://doi.org/10.1007/s11908-018-0649-2

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  • DOI: https://doi.org/10.1007/s11908-018-0649-2

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