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Zika Virus Disease and Associated Neurologic Complications

  • Neurological Infections (J Lyons, Section Editor)
  • Published:
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Abstract

Purpose of Review

The purpose of this article is to review what is currently known about Zika virus (ZIKV) disease and associated neurologic complications.

Recent Findings

ZIKV is a mosquito-borne or sexually transmitted flavivirus rapidly spreading throughout the Americas. While ZIKV infection is usually asymptomatic, it may cause a non-specific illness with fever, rash, myalgia, headache, and/or non-purulent conjunctivitis. Additionally, ZIKV has been associated with a number of neurologic complications including microcephaly and other birth defects, Guillain-Barré syndrome, meningoencephalitis, myelitis, and various ophthalmologic abnormalities.

Summary

Treatment for ZIKV disease is supportive. Those in ZIKV endemic areas should protect themselves from mosquito bites by wearing insect repellent, wearing long-sleeved shirts and pants when outdoors, and/or using air conditioning or window screens when indoors. Furthermore, unprotected sexual intercourse should be temporarily avoided by those who recently traveled to endemic areas. Suspected ZIKV disease cases should be reported to local, state, or territorial health departments.

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References

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  1. Dick GWA, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46:509–20.

    Article  CAS  PubMed  Google Scholar 

  2. Simpson DI. Zika virus infection in man. Trans R Soc Trop Med Hyg. 1964;58:335–8.

    Article  CAS  PubMed  Google Scholar 

  3. Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR, Akinkugbe FM, et al. Arthropod-borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol. 1975;69:49–64.

    Article  CAS  PubMed  Google Scholar 

  4. Fagbami AH. Zika virus infections in Nigeria: virological and seroepidemiological investigations in Oyo State. J Hyg (Lond). 1979;83:213–9.

    Article  CAS  Google Scholar 

  5. Filipe AR, Martins CM, Rocha H. Laboratory infection with Zika virus after vaccination against yellow fever. Arch Für Ges Virusforsch. 1973;43:315–9.

    Article  CAS  Google Scholar 

  6. Olson JG, Ksiazek TG, Suhandiman, Triwibowo. Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981;75:389–93.

    Article  CAS  PubMed  Google Scholar 

  7. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360:2536–43.

    Article  CAS  PubMed  Google Scholar 

  8. • Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2014;20:O595–6. Description of ZIKV spread throughout the Pacific.

    CAS  Google Scholar 

  9. Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, et al. Zika virus infection complicated by Guillain-Barre syndrome—case report, French Polynesia, December 2013. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2014;19.

  10. • Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil. Emerg Infect Dis. 2015;21:1885–6. First reports of ZIKV transmission in Brazil.

    Article  PubMed  PubMed Central  Google Scholar 

  11. • Zanluca C, de Melo VCA, Mosimann ALP, Santos GIVD, Santos CNDD, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110:569–72. First reports of ZIKV transmission in Brazil.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Musso D. Zika virus transmission from French Polynesia to Brazil. Emerg Infect Dis. 2015;21:1887.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Countries & Territories with Active Local Zika Virus Transmission. Zika virus. Center for Disease Control and Prevention. 2016. https://www.cdc.gov/zika/geo/active-countries.html. Accessed 7 July 2016.

  14. Mitchell C. PAHO WHO. Zika cumulative cases - “Zika Cumulative Cases - 25 August 2016”. Pan American Health Organization / World Health Organization. 2016. http://www.paho.org/hq/index.php?option=com_content&view=article&id=12390%3Azika-cumulative-cases&catid=8424%3Acontents&Itemid=42090&lang=en. Accessed 1 Sept 2016.

  15. Zika Virus Case Counts in the US. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/geo/united-states.html. Accessed 1 Sept 2016.

  16. Zika Virus Health Effects and Risks. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/healtheffects/index.html. Accessed 1 Sept 2016.

  17. Transmission of Zika Virus. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/transmission/index.html. Accessed 1 Sept 2016.

  18. Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, et al. Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis. 2011;17:880–2.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Hills SL, Russell K, Hennessey M, Williams C, Oster AM, Fischer M, et al. Transmission of Zika virus through sexual contact with travelers to areas of ongoing transmission - continental United States, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:215–6.

    Article  PubMed  Google Scholar 

  20. Atkinson B, Hearn P, Afrough B, Lumley S, Carter D, Aarons EJ, et al. Detection of Zika virus in semen. Emerg Infect Dis. 2016;22:940.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Deckard DT, Chung WM, Brooks JT, Smith JC, Woldai S, Hennessey M, et al. Male-to-male sexual transmission of Zika virus—Texas, January 2016. MMWR Morb Mortal Wkly Rep. 2016;65:372–4.

    Article  PubMed  Google Scholar 

  22. D’Ortenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B, Piorkowski G, et al. Evidence of sexual transmission of Zika virus. N Engl J Med. 2016;374:2195–8.

    Article  PubMed  Google Scholar 

  23. Mansuy JM, Dutertre M, Mengelle C, Fourcade C, Marchou B, Delobel P, et al. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Lancet Infect Dis. 2016;16:405.

    Article  PubMed  Google Scholar 

  24. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika virus. Emerg Infect Dis. 2015;21:359–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Barzon L, Pacenti M, Franchin E, Lavezzo E, Trevisan M, Sgarabotto D, et al. Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016. Euro Surveill. 2016;21:32.

    Google Scholar 

  26. Prisant N, Bujan L, Benichou H, Hayot P-H, Pavili L, Lurel S, et al. Zika virus in the female genital tract. Lancet Infect Dis. 2016. doi:10.1016/S1473-3099(16)30193-1.

    PubMed  Google Scholar 

  27. Venturi G, Zammarchi L, Fortuna C, Remoli ME, Benedetti E, Fiorentini C, et al. An autochthonous case of Zika due to possible sexual transmission, Florence, Italy, 2014. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2016;21.

  28. Fréour T, Mirallié S, Hubert B, Splingart C, Barrière P, Maquart M, et al. Sexual transmission of Zika virus in an entirely asymptomatic couple returning from a Zika epidemic area, France, April 2016. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2016;21.

  29. • Brooks JT, Friedman A, Kachur RE, LaFlam M, Peters PJ, Jamieson DJ. Update: interim guidance for prevention of sexual transmission of Zika virus - United States, July 2016. MMWR Morb Mortal Wkly Rep. 2016;65:745–7. Guidelines to prevent ZIKV sexual transmission.

    Article  PubMed  Google Scholar 

  30. Brooks RB, Carlos MP, Myers RA, White MG, Bobo-Lenoci T, Aplan D, et al. Likely sexual transmission of Zika virus from a man with no symptoms of infection - Maryland, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:915–6.

    Article  PubMed  Google Scholar 

  31. Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2014;19.

  32. Kuehnert MJ, Basavaraju SV, Moseley RR, Pate LL, Galel SA, Williamson PC, et al. Screening of blood donations for Zika virus infection—Puerto Rico, April 3-June 11, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:627–8.

    Article  PubMed  Google Scholar 

  33. Barjas-Castro ML, Angerami RN, Cunha MS, Suzuki A, Nogueira JS, Rocco IM, et al. Probable transfusion-transmitted Zika virus in Brazil. Transfusion (Paris). 2016;56:1684–8.

    Article  Google Scholar 

  34. Press Announcements - FDA advises testing for Zika virus in all donated blood and blood components in the US. United States Food and Drug Administration. 2016. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm518218.htm. Accessed 1 Sept 2016.

  35. Jouannic JM, Friszer S, Leparc-Goffart I, Garel C, Eyrolle-Guignot D. Zika virus infection in French Polynesia. Lancet Lond Engl. 2016;387:1051–2.

    Article  Google Scholar 

  36. Calvet G, Aguiar RS, Melo ASO, Sampaio SA, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016;16:653–60.

    Article  PubMed  Google Scholar 

  37. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis B. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2016;47:6–7.

    Article  CAS  Google Scholar 

  38. Meaney-Delman D, Hills SL, Williams C, Galang RR, Iyengar P, Hennenfent AK, et al. Zika virus infection among U.S. pregnant travelers—August 2015-February 2016. MMWR Morb Mortal Wkly Rep. 2016;65:211–4.

    Article  PubMed  Google Scholar 

  39. Martines RB, Bhatnagar J, Keating MK, Silva-Flannery L, Muehlenbachs A, Gary J, et al. Notes from the Field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:159–60. Case series with pathologic evidence of fetal ZIKV infection.

    Article  PubMed  Google Scholar 

  40. Van der Eijk AA, Van Genderen PJ, Verdijk RM, Reusken CB, Mögling R, Van Kampen JJA, et al. Miscarriage associated with Zika virus infection. N Engl J Med. 2016;375:1002–4.

    Article  PubMed  Google Scholar 

  41. Besnard M, Lastere S, Teissier A, Cao-Lormeau V, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2014;19.

  42. Dupont-Rouzeyrol M, Biron A, O’Connor O, Huguon E, Descloux E. Infectious Zika viral particles in breastmilk. Lancet Lond Engl. 2016;387:1051.

    Article  Google Scholar 

  43. Guideline: infant feeding in areas of Zika Virus Transmission. Geneva: World Health Organization. (WHO Guidelines Approved by the Guidelines Review Committee). 2016. http://www.ncbi.nlm.nih.gov/books/NBK374155/. Accessed 5 Aug 2016.

  44. Clinical Guidance for Healthcare Providers Caring for Infants and Children. Zika Virus. Center for disease control and prevention. 2014. http://www.cdc.gov/zika/hc-providers/infants-children.html. Accessed 1 Sept 2016.

  45. Zika Virus Symptoms. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/symptoms/symptoms.html. Accessed 1 Sept 2016.

  46. • Sharp TM, Muñoz-Jordán J, Perez-Padilla J, Bello-Pagán MI, Rivera A, Pastula DM, et al. Zika virus infection associated with severe thrombocytopenia. Clin Infect Dis Off Publ Infect Dis Soc Am. 2016. doi:10.1093/cid/ciw476. Case reports of severe thrombocytopenia associated with ZIKV infection.

    Google Scholar 

  47. Karimi O, Goorhuis A, Schinkel J, Codrington J, Vreden SGS, Vermaat JS, et al. Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection. Lancet Lond Engl. 2016;387:939–40.

    Article  Google Scholar 

  48. • Hennessey M, Fischer M, Staples JE. Zika virus spreads to new areas—region of the Americas, May 2015-January 2016. MMWR Morb Mortal Wkly Rep. 2016;65:55–8. Description of ZIKV spread throughout the Americas.

    Article  PubMed  Google Scholar 

  49. Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, et al. Possible association between Zika virus infection and microcephaly—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:59–62.

    Article  PubMed  Google Scholar 

  50. Zika virus microcephaly and Guillain-Barre syndrome. Geneva: World Health Organization. Situation Report. 2016. http://apps.who.int/iris/bitstream/10665/204718/1/zikasitrep_31Mar2016_eng.pdf. Accessed 31 July 2016.

  51. Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet Lond Engl. 2016;387:2125–32.

    Article  Google Scholar 

  52. Brasil P, Pereira JP, Raja Gabaglia C, Damasceno L, Wakimoto M, Ribeiro Nogueira RM, et al. Zika virus infection in pregnant women in Rio de Janeiro—preliminary report. N Engl J Med. 2016. doi:10.1056/NEJMoa1602412.

    PubMed  Google Scholar 

  53. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika virus associated with microcephaly. N Engl J Med. 2016;374:951–8.

    Article  CAS  PubMed  Google Scholar 

  54. França GVA, Schuler-Faccini L, Oliveira WK, Henriques CMP, Carmo EH, Pedi VD, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet Lond Engl. 2016;388:891–7.

    Article  Google Scholar 

  55. Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WTGH, Do Carmo GMI, Henriques CMP, Coelho GE, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:242–7.

    Article  PubMed  Google Scholar 

  56. Sarno M, Sacramento GA, Khouri R, Do Rosário MS, Costa F, Archanjo G, et al. Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise. PLoS Negl Trop Dis. 2016;10:e0004517.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med. 2016;374:2142–51.

    Article  CAS  PubMed  Google Scholar 

  58. • Hazin AN, Poretti A, Turchi Martelli CM, Huisman TA, Microcephaly Epidemic Research Group, Di Cavalcanti Souza Cruz D, et al. Computed tomographic findings in microcephaly associated with Zika virus. N Engl J Med. 2016;374:2193–5. Radiographic findings in fetal ZIKV infection.

    Article  PubMed  Google Scholar 

  59. • Martines RB, Bhatnagar J, de Oliveira Ramos AM, Davi HPF, Iglezias SD, Kanamura CT, et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet Lond Engl. 2016;388:898–904. Case series with pathologic evidence of fetal ZIKV infection.

    Article  CAS  Google Scholar 

  60. •• Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects—reviewing the evidence for causality. N Engl J Med. 2016;374:1981–7. Causal relationship established between microcephaly and Zika virus infection.

    Article  CAS  PubMed  Google Scholar 

  61. • De Fatima Vasco Aragao M, Van der Linden V, Brainer-Lima AM, Coeli RR, Rocha MA, Sobral da Silva P, et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ. 2016;353:i1901. Radiographic findings in fetal ZIKV infection.

    Article  PubMed  PubMed Central  Google Scholar 

  62. • Soares de Oliveira-Szejnfeld P, Levine D, de Oliveira Melo AS, Amorim MMR, Batista AGM, Chimelli L, et al. Congenital brain abnormalities and Zika virus: what the radiologist can expect to see prenatally and postnatally. Radiology. 2016. doi:10.1148/radiol.2016161584. Radiographic findings in fetal ZIKV infection.

    PubMed  Google Scholar 

  63. • Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell. 2016;18:587–90. Laboratory evidence of ZIKV tropism for neural stem cells.

    Article  CAS  PubMed  Google Scholar 

  64. • Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016;352:816–8. Laboratory evidence of ZIKV tropism for neural stem cells.

    Article  CAS  PubMed  Google Scholar 

  65. • Brault JB, Khou C, Basset J, Coquand L, Fraisier V, Frenkiel MP, et al. Comparative analysis between flaviviruses reveals specific neural stem cell tropism for Zika virus in the mouse developing neocortex. EBioMedicine. 2016;10:71–6. Laboratory evidence of ZIKV tropism for neural stem cells.

    Article  PubMed  PubMed Central  Google Scholar 

  66. •• Russell K, Oliver SE, Lewis L, Barfield WD, Cragan J, Meaney-Delman D, et al. Update: interim guidance for the evaluation and management of infants with possible congenital Zika virus infection—United States, August 2016. MMWR Morb Mortal Wkly Rep. 2016;65:870–8. Evaluation and management of congenital ZIKV disease.

    Article  PubMed  Google Scholar 

  67. Van der Linden V, Filho ELR, Lins OG, Van der Linden A, de Fátima Viana Vasco Aragão M, Brainer-Lima AM, et al. Congenital Zika syndrome with arthrogryposis: retrospective case series study. BMJ. 2016;354:i3899.

    Article  PubMed  PubMed Central  Google Scholar 

  68. de Carvalho Leal M, Muniz LF, da Silva Caldas Neto S, Van der Linden V, Ramos RCF. Sensorineural hearing loss in a case of congenital Zika virus. Braz J Otorhinolaryngol. 2016. doi:10.1016/j.bjorl.2016.06.001.

    Google Scholar 

  69. Clinical Guidance for Healthcare Providers Caring for Pregnant Women. Zika Virus. Center for Disease Control and Prevention. 2014. https://www.cdc.gov/zika/hc-providers/pregnant-woman.html. Accessed 1 Sept 2016.

  70. •• Cao-Lormeau VM, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J, et al. Guillain-Barré syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet Lond Engl. 2016;387:1531–9. Case–control study linking ZIKV infection with Guillain-Barré syndrome.

    Article  Google Scholar 

  71. Brasil P, Sequeira PC, Freitas AD, Zogbi HE, Calvet GA, de Souza RV, et al. Guillain-Barré syndrome associated with Zika virus infection. Lancet Lond Engl. 2016;387:1482.

    Article  Google Scholar 

  72. Kassavetis P, Joseph J-MB, Francois R, Perloff MD, Berkowitz AL. Zika virus-associated Guillain-Barré syndrome variant in Haiti. Neurology. 2016;87:336–7.

    Article  PubMed  Google Scholar 

  73. Rozé B, Najioullah F, Fergé JL, Apetse K, Brouste Y, Cesaire R, et al. Zika virus detection in urine from patients with Guillain-Barré syndrome on Martinique, January 2016. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2016;21.

  74. •• Dirlikov E, Major CG, Mayshack M, Medina N, Matos D, Ryff KR, et al. Guillain-Barré syndrome during ongoing Zika virus transmission—Puerto Rico, January 1–July 31, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:910–4. Recent prospective Zika virus-Guillain Barré syndrome surveillance system from Puerto Rico.

    Article  PubMed  Google Scholar 

  75. Siu R, Bukhari W, Todd A, Gunn W, Huang QS, Timmings P. Acute Zika infection with concurrent onset of Guillain-Barré Syndrome. Neurology. 2016. doi:10.1212/WNL.0000000000003038.

    PubMed  Google Scholar 

  76. Styczynski AR, Malta J, Krow-Lucal E, Percio J, Nobrega M, Vargas A, et al. Guillain-Barré syndrome outbreak—Bahia State, Brazil, 2015. Epidemic Intell Serv Conf Atlanta Abstract. 2016.

  77. Mécharles S, Herrmann C, Poullain P, Tran TH, Deschamps N, Mathon G, et al. Acute myelitis due to Zika virus infection. Lancet Lond Engl. 2016;387:1481.

    Article  Google Scholar 

  78. Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, et al. Zika virus associated with meningoencephalitis. N Engl J Med. 2016;374:1595–6.

    Article  PubMed  Google Scholar 

  79. Rozé B, Najioullah F, Signate A, Apetse K, Brouste Y, Gourgoudou S, et al. Zika virus detection in cerebrospinal fluid from two patients with encephalopathy, Martinique, February 2016. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2016;21.

  80. Ferreira ML. Neurologic manifestations of arboviruses in the epidemic in Pernambuco, Brazil. American Academy of Neurology 68th Annual Meeting Abstract. 10 Apr 2016. https://www.aan.com/PressRoom/home/GetDigitalAsset/12051. Accessed 1 Sept 2016.

  81. Ventura CV, Maia M, Ventura BV, Linden VVD, Araújo EB, Ramos RC, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016;79:1–3.

    PubMed  Google Scholar 

  82. Ventura CV, Maia M, Bravo-Filho V, Góis AL, Belfort R. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet Lond Engl. 2016;387:228.

    Article  Google Scholar 

  83. De Paula Freitas B, De Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol. 2016. doi:10.1001/jamaopthalmol.2016.0267.

    Google Scholar 

  84. Miranda HA, Costa MC, Frazão MAM, Simão N, Franchischini S, Moshfeghi DM. Expanded spectrum of congenital ocular findings in microcephaly with presumed Zika infection. Ophthalmology. 2016;123:1788–94.

    Article  PubMed  Google Scholar 

  85. Ventura CV, Maia M, Dias N, Ventura LO, Belfort R. Zika: neurological and ocular findings in infant without microcephaly. Lancet Lond Engl. 2016;387:2502.

    Article  Google Scholar 

  86. Furtado JM, Espósito DL, Klein TM, Teixeira-Pinto T, da Fonseca BA. Uveitis associated with Zika virus infection. N Engl J Med. 2016;375:394–6.

    Article  PubMed  Google Scholar 

  87. Parke DW, Almeida DRP, Albini TA, Ventura CV, Berrocal AM, Mittra RA. Serologically confirmed Zika-related unilateral acute maculopathy in an adult. Ophthalmology. 2016. doi:10.1016/j.optha.2016.06.039.

    Google Scholar 

  88. Testing for Zika Virus. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/hc-providers/testing-for-zikavirus.html. Accessed 2 Sept 2016.

  89. •• Rabe IB, Staples JE, Villanueva J, Hummel KB, Johnson JA, Rose L, et al. Interim guidance for interpretation of Zika virus antibody test results. MMWR Morb Mortal Wkly Rep. 2016;65:543–6. Interpretation of ZIKV diagnostic tests.

    Article  PubMed  Google Scholar 

  90. Treatment for Zika Virus. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/symptoms/treatment.html. Accessed 2 Sept 2016.

  91. • Morrison C. DNA vaccines against Zika virus speed into clinical trials. Nat Rev Drug Discov. 2016;15:521–2. Vaccines for ZIKV disease have moved into clinical trials.

    Article  CAS  PubMed  Google Scholar 

  92. Zika Virus: Prevent Mosquito Bites. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/prevention/prevent-mosquito-bites.html. Accessed 10 Sept 2016.

  93. Protection from Zika Virus During Sex. Zika Virus. Center for disease control and prevention. 2014. https://www.cdc.gov/zika/prevention/protect-yourself-during-sex.html. Accessed 2 Sept 2016.

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Authors and Affiliations

  1. Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA

    Lindsey M. Duca & Daniel M. Pastula

  2. Neuro-Infectious Diseases Group, Department of Neurology and Division of Infectious Diseases, University of Colorado Denver, Aurora, CO, USA

    J. David Beckham, Kenneth L. Tyler & Daniel M. Pastula

  3. University of Colorado School of Medicine, 12401 East 17th Avenue, Room 486, Mailstop L950, Aurora, CO, 80045, USA

    Daniel M. Pastula

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  1. Lindsey M. Duca
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Correspondence to Daniel M. Pastula.

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Duca, L.M., Beckham, J.D., Tyler, K.L. et al. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep 19, 4 (2017). https://doi.org/10.1007/s11908-017-0557-x

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