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Update on Fungal Diagnostics

  • Transplant and Oncology (M Ison, Section Editor)
  • Published:
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Abstract

Invasive fungal disease (IFD) is becoming more prevalent in transplant and oncology patients as a result of the potent immunosuppressive therapies used to prevent allograft rejection and/or the use of cytotoxic chemotherapy to treat cancer. Mortality attributable to IFD remains high despite advances in antifungal therapies. There is a continued need for laboratory diagnostics to help improve clinical outcomes. In recent years, culture-based detection strategies and histopathology have been supplemented with molecular and proteomic techniques as well as antigen detection methods. Refinements in these assays are improving the diagnosis of IFD, with the greatest strides made within the molecular and proteomic arenas. This review highlights recent laboratory developments in the diagnosis of invasive candidiasis, cryptococcosis, opportunistic molds, and endemic fungal infections.

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Allen T. Griffin has no conflicts of interest to declare and no sources of funding to declare. Kimberly E. Hanson has collaborated with BioFire on extramurally funded diagnostics research.

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Authors and Affiliations

  1. Department of Pathology, University of Utah, Salt Lake City, UT, USA

    Allen T. Griffin & Kimberly E. Hanson

  2. Department of Medicine/Division of Infectious Diseases, University of Utah, Salt Lake City, UT, USA

    Kimberly E. Hanson

  3. Associated Regional and University Pathologists (ARUP) Laboratories, University of Utah, Salt Lake City, UT, USA

    Allen T. Griffin & Kimberly E. Hanson

  4. Associated Regional and University Pathologists (ARUP), Institute for Clinical and Experimental Pathology, 500 S. Chipeta Way, Salt Lake City, UT, 84108, USA

    Allen T. Griffin

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Correspondence to Allen T. Griffin.

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This article is part of the Topical Collection on Transplant and Oncology

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Griffin, A.T., Hanson, K.E. Update on Fungal Diagnostics. Curr Infect Dis Rep 16, 415 (2014). https://doi.org/10.1007/s11908-014-0415-z

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