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Preeclampsia and the Retina

  • Preeclampsia (A Kattah, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review summarizes key findings relating to the association between preeclampsia and retinal disorders.

Recent Findings

Preeclampsia is a major cause of maternal morbidity. Pregnant women with preeclampsia frequently describe having visual disturbances. Retinal changes can be identified on fundoscopy in most patients with preeclampsia. While retinal pathology secondary to preeclampsia usually resolves postpartum, there is growing evidence that women with preeclampsia have a higher long-term risk of developing retinal disorders after pregnancy.

Summary

Pregnant women often experience visual changes. While these symptoms may be benign, careful attention should be paid to exclude retinal disorders secondary to preeclampsia. Pregnant women complaining of new-onset or worsening blurry vision, scotomata, diplopia, or photopsia require rapid and thorough evaluation to rule out hypertensive disorders. Management of preeclampsia, including administration of magnesium sulfate and delivery of the fetus, can reverse retinal pathologies in most cases.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Gilbert AL, Prasad S, Mallery RM. Neuro-ophthalmic disorders in pregnancy. Neurol Clin. 2019;37(1):85–102. https://doi.org/10.1016/j.ncl.2018.09.001.

    Article  PubMed  Google Scholar 

  2. • He X, Ji Y, Yu M, Tong Y. Chorioretinal alterations induced by preeclampsia. J Ophthalmol. 2021;8847001. https://doi.org/10.1155/2021/8847001. This review article evaluated the literature on preeclampsia-induced chorioretinal alterations published between 2000 and 2020. In women with preeclampsia, chorioretinal pathologies are associated with the severity of hypertensive disorders and usually resolve after delivery.

  3. Chappell LC, Cluver CA, Kingdom J, Tong S. Pre-eclampsia Lancet. 2021;398(10297):341–54. https://doi.org/10.1016/S0140-6736(20)32335-7.

    Article  CAS  PubMed  Google Scholar 

  4. Practice Bulletin No. 222: Gestational hypertension and preeclampsia. Am Coll Obstet Gynecol. 2020;135(6):e237–60.

    Article  Google Scholar 

  5. Digre KB. Neuro-ophthalmology and pregnancy: what does a neuro-ophthalmologist need to know? J Neuroophthalmol. 2011;31(4):381–7. https://doi.org/10.1097/WNO.0b013e31823920cb.

    Article  PubMed  Google Scholar 

  6. Soma-Pillay P, Pillay R, Wong T, Makin J, Pattinson R. The effect of pre-eclampsia on retinal microvascular caliber at delivery and post-partum. Obstet Med. 2018;11(3):116–20. https://doi.org/10.1177/1753495X17745727.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Rahman I, Saleemi G, Semple D, Stanga P. Pre-eclampsia resulting in central retinal vein occlusion. Eye. 2006;20(8):955–7. https://doi.org/10.1038/sj.eye.6702065.

    Article  CAS  PubMed  Google Scholar 

  8. •• Raposo JTBV, Melo BCDS, Maciel NFBB, Leite SD, Rebelo ÓRC, Lima AMF. Serous retinal detachment in pre-eclampsia: case report and literature review. Rev Bras Ginecol Obstet. 2020;42(11):772–773. https://doi.org/10.1055/s-0040-1718448. This case report and literature review describes the incidence, management, and prognosis of preeclamssia-induced serous retinal detachment.

  9. Auger N, Fraser WD, Paradis G, Healy-Profitós J, Hsieh A, Rhéaume M-A. Preeclampsia and long-term risk of maternal retinal disorders. Obstet Gynecol. 2017;129(1):42–9. https://doi.org/10.1097/AOG.0000000000001758.

    Article  PubMed  Google Scholar 

  10. Garg A, Wapner RJ, Ananth CV, Dale E, Tsang SH, Lee W, et al. Choroidal and retinal thickening in severe preeclampsia. Invest Ophthalmol Vis Sci. 2014;55(9):5723–9. https://doi.org/10.1167/iovs.14-14143.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Schultz KL, Birnbaum AD, Goldstein DA. Ocular disease in pregnancy. Curr Opin Ophthalmol. 2005;16(5):308–14. https://doi.org/10.1097/01.icu.0000179803.42218.cc.

    Article  PubMed  Google Scholar 

  12. Vigil-De Gracia P, Ortega-Paz L. Retinal detachment in association with pre-eclampsia, eclampsia, and HELLP syndrome. Int J Gynaecol Obstet. 2011;114(3):223–5. https://doi.org/10.1016/j.ijgo.2011.04.003.

    Article  PubMed  Google Scholar 

  13. •• Ye L, Shi M, Zhang Y, Zhang J, Zhu C, Zhou R. Risk factors and pregnancy outcomes associated with retinopathy in patients presenting with severe preeclampsia. Medicine (Baltimore). 2020;99(11):e19349. https://doi.org/10.1097/MD.0000000000019349. This was a retrospective cohort study of 534 women with severe preeclampsia hospitalized between 2013 and 2016. Severe hypertension, decreased platelet counts, elevated serum lactate dehydrogenase, and proteinuria were associated with the severity of preeclampsia-induced retinopathy.

  14. Sheth BP, Mieler WF. Ocular complications of pregnancy. Curr Opin Ophthalmol. 2001;12(6):455–63. https://doi.org/10.1097/00055735-200112000-00011.

    Article  CAS  PubMed  Google Scholar 

  15. Abu SK. The eye and visual system in the preeclampsia/eclampsia syndrome: what to expect? Saudi J Ophthalmol. 2013;27(1):51–3. https://doi.org/10.1016/j.sjopt.2012.04.003.

    Article  Google Scholar 

  16. Radha Bai Prabhu T. Serious visual (ocular) complications in pre-eclampsia and eclampsia. J Obstet Gynaecol India. 2017;67(5):343–348. https://doi.org/10.1007/s13224-017-0975-6.

  17. Torres-Vergara P, Rivera R, Escudero C. How soluble fms-like tyrosine kinase 1 could contribute to blood-brain barrier dysfunction in preeclampsia? Front Physiol. 2021;12:805082. https://doi.org/10.3389/fphys.2021.805082.

    Article  PubMed  Google Scholar 

  18. Srećković SB, Janićijević-Petrović MA, Stefanović IB, Petrović NT, Šarenac TS, Paunović SS. Bilateral retinal detachment in a case of preeclampsia. Bosn J Basic Med Sci. 2011;11(2):129–31.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Stern EM, Blace N. Ophthalmic pathology of preeclampsia. StatPearls Internet. 2023.

  20. Otero-Marquez O, Chung H, Lee CS, Choi EY, Ledesma-Gil G, Alauddin S, et al. Subretinal deposits in pre-eclampsia and malignant hypertension: implications for age-related macular degeneration. Ophthalmol Retina. 2021;5(8):750–60. https://doi.org/10.1016/j.oret.2020.10.018.

    Article  PubMed  Google Scholar 

  21. Sharma S, Rekha W, Sharma T, Downey G. Refractive issues in pregnancy. Aust N Z J Obstet Gynaecol. 2006;46(3):186–8. https://doi.org/10.1111/j.1479-828X.2006.00569.x.

    Article  PubMed  Google Scholar 

  22. Cunningham FG, Fernandez CO, Hernandez C. Blindness associated with preeclampsia and eclampsia. Am J Obstet Gynecol. 1995;172(4):1291–8. https://doi.org/10.1016/0002-9378(95)91495-1.

    Article  CAS  PubMed  Google Scholar 

  23. Rosenthal JM, Johnson MW. Management of retinal diseases in pregnant patients. J Ophthalmic Vis Res. 2018;13(1):62–5. https://doi.org/10.4103/jovr.jovr_195_17.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Naderan M. Ocular changes during pregnancy. J Curr Ophthalmol. 2018;30(3):202–10. https://doi.org/10.1016/j.joco.2017.11.012.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Magee LA, Smith GN, Bloch C, Côté A-M, Jain V, Nerenberg K, et al. Guideline No. 426: Hypertensive disorders of pregnancy: diagnosis, prediction, prevention, and management. J Obstet Gynaecol Can. 2022;44(5):547–571.e1. https://doi.org/10.1016/j.jogc.2022.03.002.

  26. Iqra HHP, Anggraini MA, Junior DGK, Andari MY, Danianto A. Serous retinal detachment in pre-eclampsia: a systematic review of case report. J Kedokt Brawijaya. 2023;198–204. https://doi.org/10.21776/ub.jkb.2023.032.03.11.

  27. Lee CS, Choi EY, Lee M, Kim H, Chung H. Serous retinal detachment in preeclampsia and malignant hypertension. Eye. 2019;33(11):1707–14. https://doi.org/10.1038/s41433-019-0461-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia-pathophysiology and clinical presentations. J Am Coll Cardiol. 2020;76(14):1690–702. https://doi.org/10.1016/j.jacc.2020.08.014.

    Article  CAS  PubMed  Google Scholar 

  29. Benschop L, Schalekamp–Timmermans S, Roeters van Lennep JE, Jaddoe VWV, Wong TY, Cheung CY, et al. Gestational hypertensive disorders and retinal microvasculature: the Generation R Study. BMC Med. 2017;15(1):153. https://doi.org/10.1186/s12916-017-0917-2.

  30. Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, et al. Preeclampsia and future cardiovascular health: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2017;10(2):e3497. https://doi.org/10.1161/CIRCOUTCOMES.116.003497.

    Article  Google Scholar 

  31. Gupta A, Kaliaperumal S, Setia S, Suchi ST, Rao VA. Retinopathy in preeclampsia: association with birth weight and uric acid level. Retina. 2008;28(8):1104–10. https://doi.org/10.1097/IAE.0b013e3181744122.

    Article  PubMed  Google Scholar 

  32. Emil E. Human eye anatomy File #: 187444476. Adobe Stock. Available from: https://stock.adobe.com/ca/images/human-eye-anatomy-vector-illustration/187444476. Accessed 2023 Jul 24.

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Acknowledgements

This study was supported by the Heart & Stroke Foundation of Canada (G-22-0031974) and the Fonds de recherche du Québec-Santé (Auger 296785).

Funding

Heart and Stroke Foundation of Canada,G-22-0031974,Fonds de Recherche du Québec—Santé,296785

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SS and NA wrote the preliminary versions of the manuscript. MAR critically appraised the manuscript for intellectual content. NA supervised the study.

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Correspondence to Nathalie Auger.

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Soullane, S., Rhéaume, MA. & Auger, N. Preeclampsia and the Retina. Curr Hypertens Rep 26, 169–174 (2024). https://doi.org/10.1007/s11906-023-01290-0

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