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Relative Roles of Principal and Intercalated Cells in the Regulation of Sodium Balance and Blood Pressure

  • Hypertension and the Kidney (RM Carey, Section Editor)
  • Published:
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Abstract

The kidney continuously adapts daily renal excretion of NaCl to match dietary intakes in order to maintain the NaCl content of the body, and keep vascular volume constant. Any situation that leads to NaCl retention favors a rise in blood pressure. The aldosterone-sensitive distal nephron, which contains two main types of cells, principal (PC) and intercalated (IC) cells, is an important site for the final regulation of urinary Na+ excretion. Research over the past 20 years established a paradigm in which PCs are the exclusive site of Na+ absorption while ICs are solely dedicated to acid-base transport. Recent studies have revealed the unexpected importance of ICs for NaCl reabsorption. Here, we review the mechanisms of Na+ and Cl− transport in the aldosterone-sensitive distal nephron, with emphasis on the role of ICs in maintaining NaCl balance and normal blood pressure.

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Acknowledgments

The authors thank Juliette Hadchouel and Dominique Eladari for critical reading of the manuscript. Thanks to all members of the laboratory for contributing to the research projects. RC is funded by the Centre National de la Recherche Scientifique, the Institut National de la Santé et de la Recherche Médicale, the Fondation pour la Recherche Médicale, the Société de Néphrologie, and l’Agence Nationale de la Recherche Projet ANR-12-BSV1-0017. FT is funded by ERA-EDTA Long Term Fellowship–LTF 141-2013.

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Conflict of Interest

Régine Chambrey and Francesco Trepiccione declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. INSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015, Paris, France

    Régine Chambrey & Francesco Trepiccione

  2. Faculté de Médecine, Université Paris-Descartes, 15 Rue de l’Ecole de Médecine, 75006, Paris, France

    Régine Chambrey & Francesco Trepiccione

  3. Department of Cardio-Thoracic and Respiratory Science, Second University of Naples, Naples, Italy

    Francesco Trepiccione

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  1. Régine Chambrey
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  2. Francesco Trepiccione
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Correspondence to Régine Chambrey.

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This article is part of the Topical Collection on Hypertension and the Kidney

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Chambrey, R., Trepiccione, F. Relative Roles of Principal and Intercalated Cells in the Regulation of Sodium Balance and Blood Pressure. Curr Hypertens Rep 17, 27 (2015). https://doi.org/10.1007/s11906-015-0538-0

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