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The Thrill of Success: Central Arterial-Venous Anastomosis for Hypertension

  • Device-Based Approaches for Hypertension (M Schlaich, Section Editor)
  • Published:
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Abstract

Excess blood pressure remains the most important risk factor for cardiovascular and renal disease. Poly pharmacy has been proved safe and effective under clinical trial circumstances; however, the majority of patients fail to sustain pharmaceutical persistence and adherence. The opportunity to offer patients a treatment or device in addition or perhaps instead of drug therapy alone may significantly broaden the options for patients and allow greater success in hypertensive therapy. In this review, we examine the potential of a fixed-volume central arterial-venous anastomosis to reduce blood pressure in hypertensive patients, review possible mechanisms by which the anastomosis may reduce blood pressure, and consider the unique clinical trial opportunities posed by this therapy.

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Conflict of Interest

Alice Stanton, Eamon Dolan, and Henry Krum declare no conflict of interest. Marat Fudim is a consultant for Cibiem, Inc. Paul A. Sobotka is a consultant for Abbott Ventures, Ardian, Boston Scientific, Medtronic, Nephera, and Ardelyx and is Chief Medical Officer for Cibiem and Rox Medical.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Vanderbilt University, Nashville, TN, USA

    Marat Fudim

  2. Royal College of Surgeons in Ireland, Dublin, Ireland

    Alice Stanton & Eamon Dolan

  3. ROX Medical Inc., The Ohio State University, St Paul, MN, USA

    Paul A. Sobotka

  4. Monash University, Alfred Hospital, Melbourne, VIC, Australia

    Henry Krum

Authors
  1. Marat Fudim
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  2. Alice Stanton
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  3. Paul A. Sobotka
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  4. Eamon Dolan
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  5. Henry Krum
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Corresponding author

Correspondence to Henry Krum.

Additional information

This article is part of the Topical Collection on Device-Based Approaches for Hypertension

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Fudim, M., Stanton, A., Sobotka, P.A. et al. The Thrill of Success: Central Arterial-Venous Anastomosis for Hypertension. Curr Hypertens Rep 16, 497 (2014). https://doi.org/10.1007/s11906-014-0497-x

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  • DOI: https://doi.org/10.1007/s11906-014-0497-x

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