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Metabolic Syndrome, Diabetes, and Cardiovascular Risk in HIV

  • Co-infections and Comorbidity (CM Wyatt and K Sigel, Section Editors)
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Abstract

HIV infection and its treatment have been associated with adipose tissue changes and disorders of glucose and lipid metabolism. The proportion of HIV-infected adults over the age of 50 is also growing placing HIV-infected adults at particular risk for metabolic perturbations and cardiovascular disease. The metabolic syndrome in HIV-infected adults has been increasingly studied but whether HIV is associated with greater risk remains unclear, likely because of the interplay of host, viral and antiretroviral factors that are associated with the components of the metabolic syndrome. The relationship between HIV and diabetes mellitus (DM) risk has also been debated. While the Framingham Risk Score is a well-accepted measure of 10-year cardiovascular risk in the general population, it may not accurately predict risk in the HIV setting due to HIV-related factors such as inflammation that are not accounted for. We summarize the recent literature on metabolic syndrome, DM, and cardiovascular risk in HIV-infected adults.

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Conflict of Interest

Linda M. Nix declares that she has no conflict of interest.

Phyllis C. Tien reports grants from NIH, personal fees from BMS, personal fees from Genentech, and personal fees from Gilead outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, University of California, San Francisco, CA, USA

    Linda M. Nix

  2. Northern California Institute for Research and Education, UCSF Box 1352, 405 Irving Street, Room 101, San Francisco, CA, 94122, USA

    Linda M. Nix

  3. Department of Medicine, University of California, San Francisco, CA, USA

    Phyllis C. Tien

  4. Department of Veterans Affairs Medical Center, Medical Service, 4150 Clement Street, 111 W, San Francisco, CA, 94121, USA

    Phyllis C. Tien

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Nix, L.M., Tien, P.C. Metabolic Syndrome, Diabetes, and Cardiovascular Risk in HIV. Curr HIV/AIDS Rep 11, 271–278 (2014). https://doi.org/10.1007/s11904-014-0219-7

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