Skip to main content
Log in

Management of Gastric and Ectopic Varices

  • Portal Hypertension and Liver Transplantation (AK Singal, Section Editor)
  • Published:
Current Hepatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Gastric varices (GV) are seen commonly in patients with portal hypertension and esophageal varices, more so in variceal bleeders. Compared to esophageal varices, there is limited data on the management of GV and ectopic varices. The current review provides a practical and updated approach for the management of patients with GV and ectopic varices.

Recent Findings

The management of isolated gastric varices (IGV) and esophageal varices continuing on the greater curvature of the stomach, the gastro-esophageal varices type 2 (GOV2) has improved significantly. Control of active bleed or prevention of rebleeding from these varices can be achieved by obturating them using endoscopic cyanoacrylate (CYA) glue injection in the majority of cases with or without the addition of beta-blocker therapy. Endoscopic ultrasound-guided coil (with/without CYA glue) injection and endovascular approaches such as transjugular intrahepatic porto-systemic shunt (TIPS) and balloon-occluded/plug-assisted retrograde transvenous occlusion (BRTO/PARTO) alone or in combination are helpful in difficult cases or uncontrolled bleeding. Similarly, in ectopic variceal bleeding, apart from endotherapy with band ligation, sclerotherapy or cyanoacrylate glue injection, TIPS and BRTO are effective approaches in difficult-to-access sites.

Summary

Multiple treatment options are now available for GV and ectopic variceal bleed involving endoscopic and endovascular approaches. Depending upon their anatomy, management of bleeding involves careful selection out of these options.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatol. 2017;65:310–35.

    Article  Google Scholar 

  2. Vashishtha C, Sarin SK. Primary prophylaxis of gastric variceal bleeding: the choices need to be tested!! Hepatol Int. 2021;15(4):863–7.

    Article  PubMed  Google Scholar 

  3. Kim T, Shijo H, Kokawa H, et al. Risk factors for hemorrhage from gastric fundal varices. Hepatol. 1997;25:307–12.

    Article  CAS  Google Scholar 

  4. Chikamori F, Kuniyoshi N, Shibuya S, Takase Y. Correlation between endoscopic and angiographic findings in patients with esophageal and isolated gastric varices. Dig Surg. 2001;18(03):176–81.

    Article  CAS  PubMed  Google Scholar 

  5. Mishra SR, Sharma BC, Kumar A, Sarin SK. Primary prophylaxis of gastric variceal bleeding comparing cyanoacrylate injection and beta-blockers: a randomized controlled trial. J Hepatol. 2011;54:1161–7.

    Article  CAS  PubMed  Google Scholar 

  6. Choe JW, Yim HJ, Lee SH, Chung HH, Lee YS, Kim SY, Hyun JJ, Jung SW, Jung YK, Koo JS, Kim JH, Seo YS, Yeon JE, Lee SW, Byun KS, Um SH. Primary prophylaxis of gastric variceal bleeding: endoscopic obturation, radiologic intervention, or observation? Hepatol Int. 2021;15(4):934–45.

    Article  PubMed  Google Scholar 

  7. Bhat YM, Weilert F, Fredrick RT, et al. EUS-guided treatment of gastric fundal varices with combined injection of coils and cyanoacrylate glue: a large U.S. experience over 6 years. Gastrointest Endosc. 2016;83:1164–72.

    Article  PubMed  Google Scholar 

  8. Tan PC, Hou MC, Lin HC, Liu TT, Lee FY, Chang FY, Lee SD. A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatol. 2006;43(4):690–7.

    Article  Google Scholar 

  9. Garcia-Pagán JC, Barrufet M, Cardenas A, Escorsell A. Management of gastric varices. Clin Gastroenterol Hepatol. 2014;12(6):919-28.e1 (quiz e51-2).

    Article  PubMed  Google Scholar 

  10. Lo GH, Lin CW, Tai CM, et al. A prospective, randomized trial of thrombin versus cyanoacrylate injection in the control of acute gastric variceal hemorrhage. Endoscopy. 2020;52(7):548–55.

    Article  PubMed  Google Scholar 

  11. Mishra SR, Chander Sharma B, Kumar A, Sarin SK. Endoscopic cyanoacrylate injection versus beta-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial. Gut. 2010;59(6):729–35.

    Article  CAS  PubMed  Google Scholar 

  12. Hung HH, Chang CJ, Hou MC, et al. Efficacy of non-selective beta-blockers as adjunct to endoscopic prophylactic treatment for gastric variceal bleeding: a randomized controlled trial. J Hepatol. 2012;56:1025–32.

    Article  CAS  PubMed  Google Scholar 

  13. •• de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Baveno VII Faculty. Baveno VII - Renewing consensus in portal hypertension. J Hepatol. 2022;76(4):959–74. https://doi.org/10.1016/j.jhep.2021.12.022Baveno consensus in portal hypertension.

    Article  PubMed  Google Scholar 

  14. Lee YT, Chan FK, Ching JYL, Lai CW, Leung VKS, Chung SCS, Sung JJY. Diagnosis of gastroesophageal varices and portal collateral venous abnormalities by endosonography in cirrhotic patients. Endoscopy. 2002;34:391–8. https://doi.org/10.1055/s-2002-25286.

    Article  CAS  PubMed  Google Scholar 

  15. Ma L, Tseng Y, Luo T, Wang J, Lian J, Tan Q, Li F, Chen S. Risk stratification for secondary prophylaxis of gastric varices due to portal hypertension. Dig Liver Dis. 2019;51:1678–84. https://doi.org/10.1016/j.dld.2019.05.020.

    Article  PubMed  Google Scholar 

  16. Lee YT, Chan FKL, Ng EKW, Leung VKS, Law KB, Yung MY, et al. EUS-guided injection of cyanoacrylate for bleeding gastric varices. Gastrointest Endosc. 2000;52:168–74.

    Article  CAS  PubMed  Google Scholar 

  17. Romero-Castro R, Pellicer-Bautista FJ, Jimenez-Saenz M, et al. EUS-guided injection of cyanoacrylate in perforating feeding veins in gastric varices: results in 5 cases. Gastrointest Endosc. 2007;66(02):402–7.

    Article  PubMed  Google Scholar 

  18. Romero-Castro R, Ellrichmann M, Ortiz-Moyano C, et al. EUS-guided coil versus cyanoacrylate therapy for the treatment of gastric varices: a multicenter study (with videos). Gastrointest Endosc. 2013;78(5):711–21. https://doi.org/10.1016/j.gie.2013.05.009.

    Article  PubMed  Google Scholar 

  19. Bick BL, Al-Haddad M, Liangpunsakul S, et al. EUS-guided fine needle injection is superior to direct endoscopic injection of 2-octyl cyanoacrylate for the treatment of gastric variceal bleeding. Surg Endosc. 2019;33:1837–45.

    Article  PubMed  Google Scholar 

  20. Bang JY, Al-Haddad MA, Chiorean M V., Chalasani NP, Kwo PY, Ghabril M, et al. Mo1485 comparison of direct endoscopic injection (DEI) and EUS-guided fine needle injection (EUS-FNI) of 2- octyl-cyanoacrylate for treatment of gastric varices. Gastrointest Endosc [Internet]. Elsevier BV; 2015;81:AB437. Available from: http://www.giejournal.org/article/S0016510715010378/fulltext. Accessed 16 Sept 2022.

  21. • Mohan BP, Chandan S, Khan SR, et al. Efficacy and safety of endoscopic ultrasound-guided therapy versus direct endoscopic glue injection therapy for gastric varices: systematic review and meta-analysis. Endoscopy. 2020;52:259–67. Meta-analysis showing comparable efficacy of EUS guided therapy as with conventional endoscopic CYA therapy with higher variceal obliteration rate.

    Article  PubMed  Google Scholar 

  22. Butler JR, Eckert GJ, Zyromski NJ, et al. Natural history of pancreatitis-induced splenic vein thrombosis: a systematic review and meta-analysis of its incidence and rate of gastrointestinal bleeding. HPB (Oxford). 2011;13:839–45.

    Article  PubMed  Google Scholar 

  23. Saad WE, Kitanosono T, Koizumi J. Balloon-occluded antegrade transvenous obliteration with or without balloon-occluded retrograde transvenous obliteration for the management of gastric varices: concept and technical applications. Tech Vasc Interv Radiol. 2012;15:203–25.

    Article  PubMed  Google Scholar 

  24. Bai M, Qi XS, Yang ZP, Wu KC, Fan DM, Han GH. EVS vs TIPS shunt for gastric variceal bleeding in patients with cirrhosis: a meta-analysis. World J Gastrointest Pharmacol Ther. 2014;5:97–104.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Lo GH, Liang HL, Chen WC, Chen MH, Lai KH, Hsu PI, Lin CK, Chan HH, Pan HB. A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy. 2007;39:679–85. https://doi.org/10.1055/s-2007-966591].

    Article  PubMed  Google Scholar 

  26. Procaccini NJ, Al-Osaimi AM, Northup P, Argo C, Caldwell SH. Endoscopic cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding: a single-center U.S. analysis. Gastrointest Endosc. 2009;70:881–7. https://doi.org/10.1016/j.gie.2009.03.1169.

    Article  PubMed  Google Scholar 

  27. Mahadeva S, Bellamy MC, Kessel D, Davies MH, Millson CE. Cost-effectiveness of N-butyl-2-cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding. Am J Gastroenterol. 2003;8:2688–93. https://doi.org/10.1111/j.1572-0241.2003.08769.x.

    Article  Google Scholar 

  28. Qi X, Tian Y, Zhang W, Yang Z, Guo X. Covered versus bare stents for transjugular intrahepatic portosystemic shunt: an updated meta-analysis of randomized controlled trials. Therap Adv Gastroenterol. 2017;10(1):32–41. https://doi.org/10.1177/1756283X16671286.

    Article  PubMed  Google Scholar 

  29. Hong CH, Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, et al. Treatment of patients with gastric variceal hemorrhage: endoscopic N-butyl-2-cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration. J Gastroenterol Hepatol. 2009;24:372–8.

    Article  PubMed  Google Scholar 

  30. Akahoshi T, Tomikawa M, Kamori M, Tsutsumi N, Nagao Y, Hashizume M, et al. Impact of balloon-occluded retrograde transvenous obliteration on management of isolated fundal gastric variceal bleeding. Hepatol Res. 2012;42:385–93.

    Article  PubMed  Google Scholar 

  31. Emori K, Toyonaga A, Oho K, Kumamoto M, Haruta T, Inoue H, et al. Balloon-occluded retrograde transvenous obliteration versus endoscopic injection sclerotherapy for isolated gastric varices: a comparative study. Kurume Med J. 2014;60:105–13.

    Article  PubMed  Google Scholar 

  32. Stein DJ, Salinas C, Sabri S, Onyeali R, Caldwell S, Henry Z. Balloon retrograde transvenous obliteration versus endoscopic cyanoacrylate in bleeding gastric varices: comparison of rebleeding and mortality with extended follow-up. J Vasc Interv Radio. 2019;30:187–94.

    Article  Google Scholar 

  33. • Luo X, Xiang T, Wu J, Wang X, Zhu Y, Xi X, Yan Y, Yang J, García-Pagán JC, Yang L. Endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration for prevention of gastric variceal bleeding: a randomized controlled trial. Hepatol. 2021;74(4):2074–84. https://doi.org/10.1002/hep.31718. RCT showing BRTO more effective than CYA in preventing GV rebleed.

    Article  CAS  Google Scholar 

  34. Kim DJ, Darcy MD, Mani NB. Modified balloon-occluded retrograde transvenous obliteration (BRTO) techniques for the treatment of gastric varices: vascular plug-assisted retrograde transvenous obliteration (PARTO)/coil-assisted retrograde transvenous obliteration (CARTO)/balloon-occluded antegrade transvenous obliteration (BATO). Cardiovasc Intervent Radiol. 2018;41:835–47.

    Article  PubMed  Google Scholar 

  35. Park JK, Saab S, Kee ST, et al. Balloon-occluded retrograde transvenous obliteration (BRTO) for treatment of gastric varices: review and meta-analysis. Dig Dis Sci. 2015;60:1543–53.

    Article  PubMed  Google Scholar 

  36. Gimm G, Chang Y, Kim H-C, et al. Balloon-occluded retrograde transvenous obliteration versus transjugular intrahepatic portosystemic shunt for the management of gastric variceal bleeding. Gut and Liver. 2018;12(6):704–13.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Kim SK, Lee KA, Sauk S, Korenblat K. Comparison of transjugular intrahepatic portosystemic shunt with covered stent and balloon-occluded retrograde transvenous obliteration in managing isolated gastric varices. Korean J Radiol. 2017;18(2):345–54.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Lee SJ, Kim SU, Kim M-D, et al. Comparison of treatment outcomes between balloon-occluded retrograde transvenous obliteration and transjugular intrahepatic portosystemic shunt for gastric variceal bleeding hemostasis. J Gastroenterol Hepatol. 2017;32(8):1487–94.

    Article  PubMed  Google Scholar 

  39. Sabri SS, Abi-Jaoudeh N, Swee W, et al. Short-term rebleeding rates for isolated gastric varices managed by transjugular intrahepatic portosystemic shunt versus balloonoccluded retrograde transvenous obliteration. J Vasc Interv Radiol. 2014;25(3):355–61.

    Article  PubMed  Google Scholar 

  40. Lee DY, Lee SJ, Kim MD, et al. Transjugular intrahepatic portosystemic shunt (TIPS) versus balloon-occluded retrograde transvenous obliteration (BRTO) for the treatment of gastric varix. Cardio Vascular Interv Radiol. 2014;37:S350.

    Google Scholar 

  41. Sauk S, Niemeyer M, Kim S, Korenblat K. Outcomes from balloon-occluded retrograde transvenous obliteration (BRTO) versus transjugular intrahepatic portosystemic shunt (TIPS) in the management of isolated gastric varices: a retrospective study in single US medical center. J Vasc Interv Radiol. 2014;25(3):S80.

    Article  Google Scholar 

  42. Lee JY, Lee YJ, Min BR, et al. Efficacy and safety of transjugular intrahepatic portosystemic shunt and balloon occluded retrograde transvenous obliteration for gastric variceal bleeding. Hepatol. 2012;56:754A.

    Google Scholar 

  43. Ninoi T, Nakamura K, Kaminou T, et al. TIPS versus transcatheter sclerotherapy for gastric varices. Am J Roentgenol. 2004;183(2):369–76.

    Article  Google Scholar 

  44. Choi YH, Yoon CJ, Park JH, Chung JW, Kwon JW, Choi GM. Balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding: its feasibility compared with transjugular intrahepatic portosystemic shunt. Korean J Radiol. 2003;4(2):109–16.

    Article  PubMed  PubMed Central  Google Scholar 

  45. • Wang ZW, Liu JC, Zhao F, Zhang WG, Duan XH, Chen PF, Yang SF, Li HW, Chen FW, Shi HS, Ren JZ. Comparison of the effects of TIPS versus BRTO on bleeding gastric varices: a meta-analysis. Can J Gastroenterol Hepatol. 2020;11(2020):5143013. https://doi.org/10.1155/2020/5143013. Meta-analysis showing better outcomes with BRTO than TIPS with lower rebleed and higher overall survival rates.

    Article  Google Scholar 

  46. Uehara H, Akahoshi T, Tomikawa M, et al. Prediction of improved liver function after balloon-occluded retrograde transvenous obliteration: relation to hepatic vein pressure gradient. J Gastroenterol Hepatol. 2012;27:137–44.

    Article  PubMed  Google Scholar 

  47. Norton ID, Andrews JC, Kamath PS. Management of ectopic varices. Hepatol. 1998;28:1154–8.

    Article  CAS  Google Scholar 

  48. Saad WEA, Lippert A, Saad NE, et al. Ectopic varices: anatomical classification, hemodynamic classification, and hemodynamic-based management. Tech Vasc Interv Radiol. 2013;16:108–25.

    Article  Google Scholar 

  49. Almadi MA, Almessabi A, Wong P, et al. Ectopic varices. Gastrointest Endosc. 2011;74:380–8.

    Article  PubMed  Google Scholar 

  50. Watanabe N, Toyonaga A, Kojima S, Takashimizu S, Oho K, Kokubu S, et al. Current status of ectopic varices in Japan: results of a survey by the Japan Society for Portal Hypertension. Hepatol Res. 2010;40:763–76.

    Article  PubMed  Google Scholar 

  51. Pennick MO, Artioukh DY. Management of parastomal varices: who rebleeds and who does not? A systematic review of the literature. Tech Coloproctol. 2013;17:163–70.

    Article  CAS  PubMed  Google Scholar 

  52. Sarin SK, Kumar CKN. Ectopic varices. Clin Liver Dis. 2012;1:168–72.

    Article  Google Scholar 

  53. Sato T, Yamazaki K, Toyota J, Karino Y, Ohmura T, Suga T. The value of the endoscopic therapies in the treatment of rectal varices: a retrospective comparison between injection sclerotherapy and band ligation. Hepatol Res. 2006;34:250–5.

    Article  PubMed  Google Scholar 

  54. Jansson-Knodell CL, Calderon G, Weber R, Ghabril M. Small intestine varices in cirrhosis at a high-volume liver transplant center: a retrospective database study and literature review. Am J Gastroenterol. 2021;116(7):1426–36.

    Article  PubMed  Google Scholar 

  55. Saad WE, Lippert A, Saad NE, et al. Ectopic varices: anatomical classification, hemodynamic classification, and hemodynamic-based management. Tech Vasc Interv Radiol. 2013;16:108–25.

    Article  Google Scholar 

  56. Vangeli M, Patch D, Terreni N, et al. Bleeding ectopic varices – treatment with transjugular intrahepatic porto-systemic shunt (TIPS) and embolisation. J Hepatol. 2004;41:560–6.

    Article  PubMed  Google Scholar 

  57. Kochar N, Tripathi D, Mc Avoy NC, Ireland H, et al. Bleeding ectopic varices in cirrhosis: the role of transjugular intrahepatic portosystemic stent shunts. Aliment Pharmacol Ther. 2008;28:294–303.

    Article  CAS  PubMed  Google Scholar 

  58. Nabeel MA, Haskal ZJ. Diagnosis and management of ectopic varices. Gastrointest Interv. 2012;1(1):3–10.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shiv Kumar Sarin.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Portal Hypertension and Liver Transplantation

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vashishtha, C., Sarin, S.K. Management of Gastric and Ectopic Varices. Curr Hepatology Rep 22, 33–43 (2023). https://doi.org/10.1007/s11901-023-00597-5

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11901-023-00597-5

Keywords

Navigation