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Common Adverse Effects of Novel Therapies for Multiple Myeloma (MM) and Their Management Strategies

  • Multiple Myeloma (P Kapoor, Section Editor)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this review was to evaluate management strategies for common adverse effects of novel therapies in multiple myeloma (MM), including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and a histone deacetylase inhibitor.

Recent Findings

There are several adverse effects that occur across multiple classes of antimyeloma drugs, including rash, peripheral neuropathy, infusion reactions, and cardiotoxicity, but most can be managed without complete discontinuation of the agent or abandonment of the class. Additionally, several agents have critically important drug-drug interactions or dose-modification implications in hepatic or renal insufficiency that can be easily overlooked, and exacerbate adverse effects.

Summary

As treatment of MM moves from fixed-duration traditional chemotherapy to novel agent-based regimens, commonly administered continuously until disease progression or intolerable toxicities, providers must adopt their management strategies for both acute and long-term adverse effects. Early and frequent monitoring for therapy-related complications, dose adjustments when needed, and timely treatment for toxicities are all important steps toward ensuring longevity of treatment from a limited array of therapeutic options that currently exist for a disease with a relapsing and remitting course.

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Authors and Affiliations

  1. Department of Pharmacy Services, Mayo Clinic, Rochester, MN, USA

    Kristen B. McCullough

  2. Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Miriam A. Hobbs & Prashant Kapoor

  3. Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA

    Jithma P. Abeykoon

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  1. Kristen B. McCullough
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Correspondence to Prashant Kapoor.

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Kristen B. McCullough, Miriam A. Hobbs, and Jithma P. Abeykoon each declare no potential conflicts of interest.

Prashant Kapoor reports grants from Takeda, Amgen, and Sanofi, of which he is a Principal Investigator of trials. Dr. Kapoor is a section editor for Current Hematologic Malignancy Reports.

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This article is part of the Topical Collection on Multiple Myeloma

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McCullough, K.B., Hobbs, M.A., Abeykoon, J.P. et al. Common Adverse Effects of Novel Therapies for Multiple Myeloma (MM) and Their Management Strategies. Curr Hematol Malig Rep 13, 114–124 (2018). https://doi.org/10.1007/s11899-018-0443-0

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