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Diagnosis and Management of Fecal Incontinence

  • Large Intestine (B Cash, Section Editor)
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Abstract

Purpose of Review

The purpose of this review is to highlight current and newer therapeutic approaches to treat fecal incontinence in patients who do not respond to conservative measures.

Recent Findings

Neurostimulation techniques, injection of bulking agents, and radiofrequency energy delivery to the anal canal have been proposed and tested for fecal incontinence over the last decade. Sacral stimulation is both effective and durable and is now the most popular of the invasive techniques whereas percutaneous tibial stimulation, radiofrequency energy, and bulking agents are either less effective or their evaluation has been handicapped by suboptimal study designs. The precise indications for the new vaginal control device and anal plugs remain to be established. The magnetic anal sphincter is disappointing. Stem cell therapy is a potentially exciting approach, which is in its infancy.

Summary

There continues to be an unmet need for innovative approaches to patients with fecal incontinence who do not respond to conservative measures. The efficacy of current and future therapies should be assessed using criteria more stringent than has been used in the past to provide a more realistic assessment of meaningful efficacy.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Ditah I, Devaki P, Luma HN, Ditah C, Njei B, Jaiyeoba C, et al. Prevalence, trends, and risk factors for fecal incontinence in United States adults, 2005-2010. Clin Gastroenterol Hepatol. 2013;12(4):636–643.e2. https://doi.org/10.1016/j.cgh.2013.07.020.

    Article  PubMed  Google Scholar 

  2. Wald A. Clinical practice. Fecal incontinence in adults. N Engl J Med. 2007;356(16):1648–55. https://doi.org/10.1056/NEJMcp067041.

    Article  CAS  PubMed  Google Scholar 

  3. Wong RK, Drossman DA, Bharucha AE, et al. The digital rectal exam: a multicenter survey of physician and students’ perceptions and practice. Am J Gastroenterol. 2012;11:947–57.

    Google Scholar 

  4. Bharucha AE, Zinsmeister AR, Schleck CD, Melton LJ III. Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in women. Gastroenterology. 2010;139(5):1559–66. https://doi.org/10.1053/j.gastro.2010.07.056.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Markland AD, Burgio KL, Whitehead WE, Richter HE, Wilcox CM, Redden DT, et al. Loperamide versus psyllium fiber for treatment of fecal incontinence: the Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial. Dis Colon rectum. 2015;58(10):983–93. https://doi.org/10.1097/DCR.0000000000000442.

    Article  PubMed  Google Scholar 

  6. Shirran E, Brazzelli M. Absorbent products for the containment of urinary and/or faecal incontinence in adults. Cochrane Database Syst Rev. 2000(2):CD001406. Review. Update in: Cochrane Database Syst Rev. 2007;(2):CD001406.

  7. Palmer KR, Corbett CL, Holdsworth CD. Double-blind cross over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology. 1980;79:1272.

    CAS  PubMed  Google Scholar 

  8. Read M, Read NW, Barber DC, Duthie HL. Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhea with fecal incontinence and urgency. Dig Dis Sci. 1982;27(9):807–14. https://doi.org/10.1007/BF01391374.

    Article  CAS  PubMed  Google Scholar 

  9. Sun WM, Read NW, Verlinden M. Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhea and fecal incontinence. Scand J Gastroenterol. 1997;32(1):34–8. https://doi.org/10.3109/00365529709025060.

    Article  CAS  PubMed  Google Scholar 

  10. Santoro GA, Estan BZ, Pryde A, Bartolo DC. Open study of low-dose amtriptyline in the treatment of patients with idiopathic fecal incontinence. Dis Colon rectum. 2000;43(12):1676–82. https://doi.org/10.1007/BF02236848.

  11. Cremonini F, Delgado-Aros S, Camilleri M. Efficacy of alosetron in irritable bowel syndrome: a meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2003;15(1):79–86. https://doi.org/10.1046/j.1365-2982.2003.00389.x.

    Article  CAS  PubMed  Google Scholar 

  12. Garsed K, Chernova J, Hastings M, Lam C, Marciani L, Singh G, et al. A randomized trial of ondansetron for the treatment of irritable bowel syndrome with diarrhea. Gut. 2014;63(10):1617–25. https://doi.org/10.1136/gutjnl-2013-305989.

    Article  CAS  PubMed  Google Scholar 

  13. Lembo A, Lacy BE, Zuckerman MJ, et al. Eluxadoline for irritable bowel syndrome with diarrhea. N Engl J Med. 2016;374(3):242–53. https://doi.org/10.1056/NEJMoa1505180.

    Article  CAS  PubMed  Google Scholar 

  14. Wedlake L, A’Hern R, Russell D, et al. Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhea predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2009;30(7):707–17. https://doi.org/10.1111/j.1365-2036.2009.04081.x.

    Article  CAS  PubMed  Google Scholar 

  15. Wald A, Tunuguntla AK. Anorectal sensorimotor dysfunction in fecal incontinence and diabetes mellitus. Modification with biofeedback therapy. N Engl J Med. 1984;310(20):1282–7. https://doi.org/10.1056/NEJM198405173102003.

    Article  CAS  PubMed  Google Scholar 

  16. Chiarioni G, Bassotti G, Stanganini S, et al. Sensory retraining is key to biofeedback therapy for formed stool fecal incontinence. Am J Gastroenterology. 2002;97(1):109–17. https://doi.org/10.1111/j.1572-0241.2002.05429.x.

    Article  CAS  Google Scholar 

  17. Heymen S, Scarlett Y, Jones K, Ringel Y, Drossman D, Whitehead WE. Randomized controlled trial shows biofeedback to be superior to pelvic floor exercises for fecal incontinence. Dis Colon rectum. 2009;52(10):1730–7. https://doi.org/10.1007/DCR.0b013e3181b55455.

  18. • Whitehead WE, Rao SS, Lowry A, et al. Treatment of fecal incontinence: state of the science summary for the NIDDK workshop. Am J Gastroenterol. 2015;110(1):138–46. The current issues regarding the management and treatment of fecal incontinence and current unmet needs. https://doi.org/10.1038/ajg.2014.303.

    Article  PubMed  Google Scholar 

  19. Bravo Gutierrez A, Madoff RD, Lowry AC, Parker SC, Buie WD, Baxter NN. Long-term results of anterior sphincteroplasty. Dis Colon rectum 2004;47(5):727–731; discussion 731-2, DOI: https://doi.org/10.1007/s10350-003-0114-6.

  20. Halverson AL, Hull TL. Long-term outcome of overlapping anal sphincter repair. Dis Colon rectum. 2002;45(3):345–8. https://doi.org/10.1007/s10350-004-6180-6.

  21. Bharucha AE, Rao SSC, Shin A. Surgical interventions and the use of device-aided therapy for the treatment of fecal incontinence and defecatory disorders. Clin Gastro Hepatol 2017.

  22. • Wald A, Bharucha AE, Cosman BC, Whitehead WE. ACG clinical guideline: management of benign anorectal disorders. Am J Gastroenterol. 2014;109(8):1141–57. https://doi.org/10.1038/ajg.2014.190. (Quiz) 1058. The most recent guidelines for the diagnosis and treatment of benign anorectal disorders, including fecal incontinence.

    Article  PubMed  Google Scholar 

  23. Leroi AM, Michot F, Grise P, Denis P. Effect of sacral nerve stimulation in patients with fecal and urinary incontinence. Dis Colon rectum. 2001;44(6):779–89. https://doi.org/10.1007/BF02234695.

    Article  CAS  PubMed  Google Scholar 

  24. Wexner SD, Coller JA, Devroede G, Hull T, McCallum R, Chan M, et al. Sacral nerve stimulation for fecal incontinence: results of a 120-patient prospective multicenter study. Ann Surg. 2010;251(3):441–9. https://doi.org/10.1097/SLA.0b013e3181cf8ed0.

    Article  PubMed  Google Scholar 

  25. Mellgren A, Wexner SD, Coller JA, et al. Long-term efficacy and safety of sacral nerve stimulation for fecal incontinence. DCR. 2011;54(9):1065–75.

    Google Scholar 

  26. • Hull T, Giese C, Wexner SD, et al. Long-term durability of sacral nerve stimulation therapy for chronic fecal incontinence. DCR. 2013;56(2):234–45. The 5-year follow-up data of the US multicenter study which extends the reports in ref. 24 and 25

    Google Scholar 

  27. Janssen PTJ, Kuiper SZ, Stassen LPS, Bouvy ND, Breukink SO, Melenhorst J. Fecal incontinence treated by sacral neuromodulation: long-term follow-up of 325 patients. Surgery. 2017;161(4):1040–8. https://doi.org/10.1016/j.surg.2016.10.038.

    Article  PubMed  Google Scholar 

  28. • Paquette IM, Varma MG, Kaiser AM, et al. The American Society of Colon and Rectal Surgeons’ Clinical Practice Guideline for the treatment of fecal incontinence. DCR. 2015;58(7):623. A companion guideline for reference 6 for fecal incontinence from a surgical viewpoint.

    Google Scholar 

  29. Carrington EV, Evers J, Grossi W, et al. A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. NGM. 2014;26(9):1222–35.

    CAS  Google Scholar 

  30. Patton V, Wiklendt L, Arkwright JW, Lubowski DZ, Dinning PG. The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence. Br J Surg. 2013;100(7):959–68. https://doi.org/10.1002/bjs.9114.

    Article  CAS  PubMed  Google Scholar 

  31. Peters KM. Alternative approaches to sacral nerve stimulation. Int Urogynecol J. 2010;21(12):1559–63. https://doi.org/10.1007/s00192-010-1282-2.

    Article  PubMed  Google Scholar 

  32. Leroi AM, Siproudhis L, Etienney I, Damon H, Zerbib F, Amarenco G, et al. Transcutaneous electrical tibial nerve stimulation in the treatment of fecal incontinence: a randomized trial (CONSORT 1a). Am J Gastroenterol. 2012;107(12):1888–96. https://doi.org/10.1038/ajg.2012.330.

    Article  CAS  PubMed  Google Scholar 

  33. Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, et al. Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults CONFIDeNT: a double blind, multicenter pragmatic parallel group randomized controlled trial. Lancet. 2015;386(10004):1640–8. https://doi.org/10.1016/S0140-6736(15)60314-2.

    Article  PubMed  Google Scholar 

  34. • van der Wilt AA, Giuliani G, Kubis C, van Wunnik BPW, Ferreira I, Breukink SO, et al. Randomized clinical trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in patients with fecal incontinence. BJS. 2017;104(9):1167–74. A well done study which demonstrates the lack of efficacy of PNTL for fecal incontinence. https://doi.org/10.1002/bjs.10590.

    Article  Google Scholar 

  35. Maeda Y, Laurberg S, Norton C. Perianal injectable bulking agents as treatment for faecal incontinence in adults. Cochrane Database Syst Rev. 2013;2:CD007959. https://doi.org/10.1002/14651858.CD007959.pub3. Review

    Google Scholar 

  36. Graf W, Mellgren A, Matzel KE, Hull T, Johansson C, Bernstein M. Efficacy of dextranomer in stabilised hyaluronic acid for treatment of faecal incontinence: a randomised, sham-controlled trial. Lancet. 2011;377(9770):997–1003. https://doi.org/10.1016/S0140-6736(10)62297-0.

    Article  CAS  PubMed  Google Scholar 

  37. Molitierno JA, Scherz HC, Kirsch AJ. Endoscopic treatment of vesicoureteral reflux using dextranomer hyaluronic acid copolymer. J Pediatr Urol. 2008 Jun;4(3):221–8. https://doi.org/10.1016/j.jpurol.2007.11.015.

    Article  PubMed  Google Scholar 

  38. Rockwood TH, Church JM, Fleshman JW, Kane RL, Mavrantonis C, Thorson AG, Wexner SD, Bliss D, Lowry AC Fecal incontinence quality of life scale: quality of life instrument for patients with fecal incontinence. Dis Colon rectum 2000;43(1):9–16; discussion 16-7, DOI: https://doi.org/10.1007/BF02237236.

  39. Dehli T, Stordahl A, Vatten LJ, Romundstad PR, Mevik K, Sahlin Y, et al. Sphincter training or anal injections of dextranomer for treatment of anal incontinence: a randomized trial. Scand J Gastroenterol. 2013 Mar;48(3):302–10. https://doi.org/10.3109/00365521.2012.758770.

    Article  PubMed  Google Scholar 

  40. • Rydingen M, Dehli T, Wilsgaard T, et al. Sacral neuromodulation compared with injection of bulking agents for fecal incontinence following obstetric anal sphincter injury: a randomized controlled study. Color Dis. 2017;19(5):O134–44. A well-done study which demonstrates the inferiority of injectable bulking agents to SNS. https://doi.org/10.1111/codi.13632.

    Article  Google Scholar 

  41. Efron JE, Corman ML, Fleshman J, Barnett J, Nagle D, Birnbaum E, Weiss EG, Nogueras JJ, Sligh S, Rabine J, Wexner SD Safety and effectiveness of temperature-controlled radio-frequency energy delivery to the anal canal (Secca procedure) for the treatment of fecal incontinence. Dis Colon rectum 2003;46(12):1606–1616; discussion 1616-8, DOI: https://doi.org/10.1007/BF02660763.

  42. Lefebure B, Tuech JJ, Bridoux V, Gallas S, Leroi AM, Denis P, et al. Temperature-controlled radio frequency energy delivery (Secca procedure) for the treatment of fecal incontinence: results of a prospective study. Int J Color Dis. 2008;23(10):993–7. https://doi.org/10.1007/s00384-008-0514-0.

    Article  CAS  Google Scholar 

  43. Kim DW, Yoon HM, Park JS, Kim YH, Kang SB. Radiofrequency energy delivery to the anal canal: is it a promising new approach to the treatment of fecal incontinence? Am J Surg. 2009;197(1):14–8. https://doi.org/10.1016/j.amjsurg.2007.11.023.

    Article  PubMed  Google Scholar 

  44. Visscher AP, Lam TJ, Meurs-Szojda MM, Felt-Bersma JF. Temperature-controlled delivery of radiofrequency energy in fecal incontinence: a randomized sham-controlled clinical trial. Dis Colon rectum. 2017;60(8):860–5. https://doi.org/10.1097/DCR.0000000000000861.

    Article  PubMed  Google Scholar 

  45. Richter HE, Matthews CA, Muir T, Takase-Sanchez MM, Hale DS, van Drie D, et al. A vaginal bowel-control system for the treatment of fecal incontinence. Obstet Gynecol. 2015;125(3):540–7. https://doi.org/10.1097/AOG.0000000000000639.

    Article  PubMed  Google Scholar 

  46. Deutekom M, Dobben AC. Plugs for containing faecal incontinence. Cochrane Database Syst Rev 2015;7:CD005086. doi: https://doi.org/10.1002/14651858.CD005086.pub4. Review.

  47. Lukacz ES, Segall MM, Wexner SD. Evaluation of an anal insert device for the conservative management of fecal incontinence. Dis Colon rectum. 2015;58(9):892–8. https://doi.org/10.1097/DCR.0000000000000427.

  48. Sugrue J, Lehur PA, Madoff RD, et al. Long-term experience of magnetic anal sphincter augmentation in patients with fecal incontinence. DCR. 2017;60(1):87–95.

    Google Scholar 

  49. Bartolotti M. The disappointing performance of the new “magnetic sphincters”: a wrong idea or a wrong realization? J Gastrointest Liver Dis. 2015;24(2):149–50.

    Google Scholar 

  50. Bisson A, Freret M, Drouot L, et al. Restoration of anal sphincter function after myoblast cell therapy in incontinent rats. Cell Transplant. 2015;24(2):277–86. https://doi.org/10.3727/096368913X674053.

    Article  PubMed  Google Scholar 

  51. Frudinger A, Pfeifer J, Paede J, Kolovetsiou-Kreiner V, Marksteiner R, Halligan S. Autologous skeletal-muscle-derived cell injection for anal incontinence due to obstetric trauma: a 5-year follow-up of an initial study of 10 patients. Color Dis. 2015;17(9):794–801. https://doi.org/10.1111/codi.12947.

    Article  CAS  Google Scholar 

  52. • Boyer O, Bridoux V, Giverne C et al. Autologous myoblasts for the treatment of fecal incontinence: results of a phase 2 randomized placebo-controlled study (MIAS). Ann Surgery. 2017. The first controlled study of an exciting new approach to patients with unrepairable anal sphincter injury.

  53. Wald A. New treatments for fecal incontinence: update for the gastroenterologist. Clin Gastro and Hepatol. 2014;12(11):1783–8. https://doi.org/10.1016/j.cgh.2014.02.013.

    Article  Google Scholar 

  54. Heymen S, Palsson O, Simren M, Whitehead WE. Patient preferences for endpoints in fecal incontinence. Neurogastroenterol Motil. 2017;29(5):e13032. https://doi.org/10.1111/nmo.13032.

    Article  Google Scholar 

  55. Carrington EV, Heinrich H, Knowles CH, Rao SS, Fox M, Scott SM, et al. Methods of anorectal manometry vary widely in clinical practice: results from an international survey. Neurogastroenterol Motil. 2017;29(8):e13016. https://doi.org/10.1111/nmo.13016.

    Article  Google Scholar 

  56. Coss-Adames E, Rao SS, et al. Accuracy and reproducibility of high definition anorectal manometry and pressure topography analyses in healthy subjects. Clin Gastro Hepatol. 2015;13(6):1143–50. https://doi.org/10.1016/j.cgh.2014.12.034.

    Article  Google Scholar 

  57. Mion F, Garros A, Brochard C, Vitton V, Ropert A, Bouvier M, et al. 3D high definition anorectal manometry: values obtained in asymptomatic volunteers, fecal incontinence and chronic constipation: results of a prospective multicenter study (NOMAD). Neurogastroenterol Motil. 2017;29(8) https://doi.org/10.1111/nmo.

  58. Basilisco G, Bharucha AE. High resolution anorectal manometry: an expensive hobby or worth every penny? Neurogastroenterol Motil. 2017;29(8):e13125. https://doi.org/10.1111/nmo.13125.

    Article  Google Scholar 

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Correspondence to Arnold Wald.

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Wald, A. Diagnosis and Management of Fecal Incontinence. Curr Gastroenterol Rep 20, 9 (2018). https://doi.org/10.1007/s11894-018-0614-0

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