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Prevalence of Diabetes in Patients with Hyperuricemia and Gout: A Systematic Review and Meta-analysis

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Abstract

Purpose of Review

To perform a systematic review and meta-analysis of the prevalence of diabetes in patients with hyperuricemia and gout.

Recent Findings

Previous studies have confirmed that hyperuricemia and gout are associated with an increased risk of diabetes. A previous meta-analysis indicated that the prevalence of diabetes in patients with gout is 16%.

Summary

Thirty-eight studies (458,256 patients) were included in the meta-analysis. The combined prevalence of diabetes among patients with hyperuricemia and gout were 19.10% (95% confidence interval [CI]: 17.60-20.60; I2 = 99.40%) and 16.70% (95% CI: 15.10-18.30; I2 = 99.30%), respectively. Patients from North America showed a higher prevalence of diabetes (hyperuricemia: 20.70% [95% CI: 16.80-24.60], gout: 20.70% [95% CI: 16.80-24.60]) than those from other continents. Older patients with hyperuricemia and those using diuretics showed a higher prevalence of diabetes than younger patients and those who were not using diuretics. Studies with a small sample size, case-control design, and low quality score had a higher prevalence of diabetes than studies with a large sample size, other designs, and a high quality score. The prevalence of diabetes among patients with hyperuricemia and gout is high. Controlling plasma glucose and uric acid levels of patients with hyperuricemia and gout is critical for the prevention of diabetes.

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Data Availability

The datasets are available from the corresponding author on reasonable request.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (grant number 81903302), the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (grant number YESS20200151), and the 345 Talent Project of Shengjing Hospital of China Medical University (grant number M0294).

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Author notes

  1. Jinguo Jiang and Tingjing Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, China Medical University, Shenyang, China

    Jinguo Jiang, Yashu Liu, Qing Chang, Yuhong Zhao, Chuanji Guo & Yang Xia

  2. Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, China

    Jinguo Jiang, Yashu Liu, Qing Chang, Yuhong Zhao, Chuanji Guo & Yang Xia

  3. School of Public Health, Wannan Medical College, Wuhu, China

    Tingjing Zhang

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  1. Jinguo Jiang
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Contributions

Jinguo Jiang: Conceptualization, Formal analysis, Visualization, Writing-original draft. Tingjing Zhang: Writing-review & editing. Yashu Liu: Writing-review & editing. Qing Chang: Writing-review & editing. Yuhong Zhao: Writing-review & editing. Chuanji Guo: Conceptualization, Resources, Writing-review & editing, Supervision. Yang Xia: Conceptualization, Resources, Writing-review & editing, Supervision, Funding acquisition.

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Jiang, J., Zhang, T., Liu, Y. et al. Prevalence of Diabetes in Patients with Hyperuricemia and Gout: A Systematic Review and Meta-analysis. Curr Diab Rep 23, 103–117 (2023). https://doi.org/10.1007/s11892-023-01506-2

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