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The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy

  • Diabetes and Pregnancy (M-F Hivert and CE Powe, Section Editors)
  • Published:
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Abstract

Purpose of Review

Gestational diabetes mellitus (GDM) is a common pregnancy complication conferring an increased risk to the individual of developing type 2 diabetes. As such, a thorough understanding of the pathophysiology of GDM is warranted. Hexokinase domain containing protein-1 (HKDC1) is a recently discovered protein containing hexokinase activity which has been shown to be associated with glucose metabolism during pregnancy. Here, we discuss recent evidence suggesting roles for the novel HKDC1 in gestational glucose homeostasis and the development of GDM and overt diabetes.

Recent Findings

Genome-wide association studies identified variants of the HKDC1 gene associated with maternal glucose metabolism. Studies modulating HKDC1 protein expression in pregnant mice demonstrate that HKDC1 has roles in whole-body glucose utilization and nutrient balance, with liver-specific HKDC1 influencing insulin sensitivity, glucose tolerance, gluconeogenesis, and ketone production.

Summary

HKDC1 has important roles in maintaining maternal glucose homeostasis extending beyond traditional hexokinase functions and may serve as a potential therapeutic target.

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Authors and Affiliations

  1. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL, USA

    Joseph L. Zapater, Kristen R. Lednovich & Brian T. Layden

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  1. Joseph L. Zapater
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Correspondence to Brian T. Layden.

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Joseph L. Zapater, Kristen R. Lednovich, and Brian T. Layden declare that they have no conflict of interest.

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This article does not contain any studies with human subjects performed by any of the authors. All reported studies/experiments with animal subjects performed by the authors have been previously published and complied with all applicable ethical standards.

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Zapater, J.L., Lednovich, K.R. & Layden, B.T. The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy. Curr Diab Rep 21, 27 (2021). https://doi.org/10.1007/s11892-021-01394-4

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