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Diabetes Management During Breastfeeding in Women with Type 1 Diabetes

  • Diabetes and Pregnancy (M-F Hivert and CE Powe, Section Editors)
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Abstract

Purpose of Review

To provide an update on glycemic management of type 1 diabetes during breastfeeding with focus on diet and insulin treatment to prevent hypoglycemia, ketoacidosis, and weight retention. Recommendations for insulin pump settings are given.

Recent Findings

Women with type 1 diabetes are encouraged to breastfeed. Hypoglycemia is a concern in the breastfeeding period among women with type 1 diabetes, and ketoacidosis may also occur. The usual goals for glucose values for persons with diabetes also apply during breastfeeding. The recommended minimum daily carbohydrate intake is 210 g during breastfeeding, and this may contribute to prevention of hypoglycemia and ketoacidosis while aiming for gradual weight loss. Insulin requirements are 21% lower during breastfeeding than before pregnancy.

Summary

Diabetes management in breastfeeding women with type 1 diabetes includes the same goals for glucose values as in other persons with diabetes, sufficient carbohydrate intake, and adequate reduction in insulin dose.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Protecting, promoting and supporting breastfeeding: the special role of maternity services. A joint WHO/UNICEF statement. Int J Gynaecol Obstet. 1990;31, 1(Suppl):171–83.

  2. Bergmann KE, Bergmann RL, Von KR, Bohm O, Richter R, Dudenhausen JW, et al. Early determinants of childhood overweight and adiposity in a birth cohort study: role of breast-feeding. Int J Obes Relat Metab Disord. 2003;27:162–72.

    PubMed  CAS  Google Scholar 

  3. Feig DS, Lipscombe LL, Tomlinson G, Blumer I. Breastfeeding predicts the risk of childhood obesity in a multi-ethnic cohort of women with diabetes. J Matern Fetal Neonatal Med. 2011;24:511–5.

    PubMed  Google Scholar 

  4. Hummel S, Pfluger M, Kreichauf S, Hummel M, Ziegler AG. Predictors of overweight during childhood in offspring of parents with type 1 diabetes. Diabetes Care. 2009;32:921–5.

    PubMed  PubMed Central  Google Scholar 

  5. Weyermann M, Rothenbacher D, Brenner H. Duration of breastfeeding and risk of overweight in childhood: a prospective birth cohort study from Germany. Int J Obes. 2006;30:1281–7.

    CAS  Google Scholar 

  6. Borch-Johnsen K, Joner G, Mandrup-Poulsen T, Christy M, Zachau-Christiansen B, Kastrup K, et al. Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus. A hypothesis. Lancet. 1984;2:1083–6.

    PubMed  CAS  Google Scholar 

  7. Kimpimaki T, Erkkola M, Korhonen S, Kupila A, Virtanen SM, Ilonen J, et al. Short-term exclusive breastfeeding predisposes young children with increased genetic risk of type I diabetes to progressive beta-cell autoimmunity. Diabetologia. 2001;44:63–9.

    PubMed  CAS  Google Scholar 

  8. Sadauskaite-Kuehne V, Ludvigsson J, Padaiga Z, Jasinskiene E, Samuelsson U. Longer breastfeeding is an independent protective factor against development of type 1 diabetes mellitus in childhood. Diabetes Metab Res Rev. 2004;20:150–7.

    PubMed  Google Scholar 

  9. Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am J Clin Nutr. 2006;84:1043–54.

    PubMed  CAS  Google Scholar 

  10. Pettitt DJ, Forman MR, Hanson RL, Knowler WC, Bennett PH. Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians. Lancet. 1997;350:166–8.

    PubMed  CAS  Google Scholar 

  11. Butte NF, King JC. Energy requirements during pregnancy and lactation. Public Health Nutr. 2005;8:1010–27.

    PubMed  Google Scholar 

  12. Dewey KG. Energy and protein requirements during lactation. Annu Rev Nutr. 1997;17:19–36.

    PubMed  CAS  Google Scholar 

  13. Herskin CW, Stage E, Barfred C, Emmersen P, Ladefoged Nichum V, Damm P, et al. Low prevalence of long-term breastfeeding among women with type 2 diabetes. J Matern Fetal Neonatal Med. 2015:1–6.

  14. Stage E, Norgard H, Damm P, Mathiesen E. Long-term breast-feeding in women with type 1 diabetes. Diabetes Care. 2006;29:771–4.

    PubMed  Google Scholar 

  15. Hummel S, Winkler C, Schoen S, Knopff A, Marienfeld S, Bonifacio E, et al. Breastfeeding habits in families with type 1 diabetes. Diabet Med. 2007;24:671–6.

    PubMed  CAS  Google Scholar 

  16. Schoen S, Sichert-Hellert W, Hummel S, Ziegler AG, Kersting M. Breastfeeding duration in families with type 1 diabetes compared to non-affected families: results from BABYDIAB and DONALD studies in Germany. Breastfeed Med. 2008;3:171–5.

    PubMed  Google Scholar 

  17. Sparud-Lundin C, Wennergren M, Elfvin A, Berg M. Breastfeeding in women with type 1 diabetes: exploration of predictive factors. Diabetes Care. 2011;34:296–301.

    PubMed  PubMed Central  Google Scholar 

  18. Fallon A, Dunne F. Breastfeeding practices that support women with diabetes to breastfeed. Diabetes Res Clin Pract. 2015;110:10–7.

    PubMed  Google Scholar 

  19. Berg M, Erlandsson LK, Sparud-Lundin C. Breastfeeding and its impact on daily life in women with type 1 diabetes during the first six months after childbirth: a prospective cohort study. Int Breastfeed J. 2012;7:20.

    PubMed  PubMed Central  Google Scholar 

  20. Achong N, Duncan EL, McIntyre HD, Callaway L. Peripartum management of glycemia in women with type 1 diabetes. Diabetes Care. 2014;37:364–71.

    PubMed  Google Scholar 

  21. Achong N, McIntyre HD, Callaway L, Duncan EL. Glycaemic behaviour during breastfeeding in women with type 1 diabetes. Diabet Med. 2015;7:52–9.

    Google Scholar 

  22. Inkster B, Elder J, Alexander C, Osborne L, Zammitt NN, Frier BM. Post-partum hypogycaemia in lactating women with type 1 diabetes: a pilot study using continuous glucose monitoring. Br J Diab. 2015;15:115–22.

    Google Scholar 

  23. •• Norgaard SK, Norgaard K, Roskjaer AB, Mathiesen ER, Ringholm L. Insulin pump settings during breastfeeding in women with type 1 diabetes. Diabetes Technol Ther. 2019. The first clinical study exploring insulin pump settings during breastfeeding in women with type 1 diabetes. They maintained good glycemic control with a low prevalence of hypoglycemia. The insulin pump settings remained mostly stable from 1 to 6 months after delivery with 14% lower basal insulin rates and 10% higher carbohydrate-to-insulin ratios than the pre-pregnancy settings.

  24. •• Ringholm L, Roskjaer AB, Engberg S, Andersen HU, Secher AL, Damm P, et al. Breastfeeding at night is rarely followed by hypoglycaemia in women with type 1 diabetes using carbohydrate counting and flexible insulin therapy. Diabetologia. 2019;62:387–98. The first clinical study on intermittent continuos glucose monitoring use during breastfeeding in the 6-month period after delivery. The percentage of night-time spent in hypoglycemia was low in the breastfeeding women with type 1 diabetes who consumed appropriate amounts of carbohydrate and had insulin doses properly reduced. Hypoglycemia within 3 h after breastfeeding was rare.

    PubMed  CAS  Google Scholar 

  25. •• Roeder HA, Moore TR, Ramos GA. Changes in postpartum insulin requirements for patients with well-controlled type 1 diabetes. Am J Perinatol. 2016;33:683–7. A recent study of 44 women with well-controlled type 1 diabetes demonstrating a 34% decrease in insulin requirements 6 weeks after delivery when compared with pre-conception. Insulin dosages were not impacted by administration route (multiple daily injections or insulin pump therapy) or breastfeeding.

    PubMed  Google Scholar 

  26. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids (Macronutrients). http://www.nap.edu/read/10490/chapter/8#293. Accessed February 2nd 2020.

  27. Kitzmiler JL, editor. Inturrisi MTA BJKJ: Breast-feeding and diabetes. In: Managing Preexisting Diabetes and Pregnancy: American Diabetes Association; 2008. p. 697–728.

  28. Bell KJ, Barclay AW, Petocz P, Colagiuri S, Brand-Miller JC. Efficacy of carbohydrate counting in type 1 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2014;2:133–40.

    PubMed  Google Scholar 

  29. Schmidt S, Schelde B, Norgaard K. Effects of advanced carbohydrate counting in patients with type 1 diabetes: a systematic review. Diabet Med. 2014;31:886–96.

    PubMed  CAS  Google Scholar 

  30. Arnhold M, Quade M, Kirch W. Mobile applications for diabetics: a systematic review and expert-based usability evaluation considering the special requirements of diabetes patients age 50 years or older. J Med Internet Res. 2014;16:e104.

    PubMed  PubMed Central  Google Scholar 

  31. Bentley-Lewis R, Goldfine AB, Green DE, Seely EW. Lactation after normal pregnancy is not associated with blood glucose fluctuations. Diabetes Care. 2007;30:2792–3.

    PubMed  PubMed Central  CAS  Google Scholar 

  32. Colatrella A, Framarino M, Toscano V, Bongiovanni M, Festa C, Mattei L, et al. Continuous glucose monitoring during breastfeeding in women with recent gestational diabetes mellitus. Diabetes Technol Ther. 2012;14:576–82.

    PubMed  CAS  Google Scholar 

  33. Jovanovic L, Nakai Y. Successful pregnancy in women with type 1 diabetes: from preconception through postpartum care. Endocrinol Metab Clin North Am. 2006;35:79–97, vi.

    PubMed  Google Scholar 

  34. Neubauer SH. Lactation in insulin-dependent diabetes. Prog Food Nutr Sci. 1990;14:333–70.

    PubMed  CAS  Google Scholar 

  35. Stubblefield NE. Nutrition management of diabetes during pregnancy. Top Clin Nutr. 1988;3:58–63.

    Google Scholar 

  36. Riviello C, Mello G, Jovanovic LG. Breastfeeding and the basal insulin requirement in type 1 diabetic women. Endocr Pract. 2009;15:187–93.

    PubMed  Google Scholar 

  37. Seaquist ER, Anderson J, Childs B, Cryer P, Dagogo-Jack S, Fish L, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013;36:1384–95.

    PubMed  PubMed Central  CAS  Google Scholar 

  38. Management of diabetes from preconception to the postnatal period: summary of NICE guidance. BMJ. 2008;336:714–7.

  39. Altus P, Hickman JW. Severe spontaneous ‘bovine’ ketoacidosis in a lactating woman. J Indiana State Med Assoc. 1983;76:392–3.

    PubMed  CAS  Google Scholar 

  40. Gleeson S, Mulroy E, Clarke DE. Lactation ketoacidosis: an unusual entity and a review of the literature. Perm J. 2016;20:71–3.

    PubMed  PubMed Central  Google Scholar 

  41. Goff JP. Major advances in our understanding of nutritional influences on bovine health. J Dairy Sci. 2006;89:1292–301.

    PubMed  CAS  Google Scholar 

  42. Sloan G, Ali A, Webster J. A rare cause of metabolic acidosis: ketoacidosis in a non-diabetic lactating woman. Endocrinol Diabetes Metab Case Rep. 2017. https://doi.org/10.1530/EDM-17-0073.

  43. Azzam O, Prentice D. Lactation ketoacidosis: an easily missed diagnosis. Intern Med J. 2019;49:256–9.

    PubMed  Google Scholar 

  44. von Geijer L, Ekelund M. Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: a case report. J Med Case Rep. 2015;9:224.

    Google Scholar 

  45. • Al Alawi AM, Falhammar H. Lactation ketoacidosis: case presentation and literature review. BMJ Case Rep 2018. 2018. https://doi.org/10.1136/bcr-2017-223494. Presentation of a case of lactation ketoacidosis in a woman without diabetes who followed a low-carbohydrate diet during breastfeeding. A literature review of published cases of lactation ketoacidosis is also presented.

  46. Chernow B, Finton C, Rainey TG, O’Brian JT. “Bovine ketosis” in a nondiabetic postpartum woman. Diabetes Care. 1982;5:47–9.

    PubMed  CAS  Google Scholar 

  47. Al Alawi AM, Al AU, Falhammar H. Lactation ketoacidosis: a case series. Sultan Qaboos Univ Med J. 2019;19:e359–63.

    PubMed  PubMed Central  Google Scholar 

  48. Chew MS, Dalesjo L. Life-threatening ketoacidosis in a lactating woman. Eur J Anaesthesiol. 2018;35:984–6.

    PubMed  Google Scholar 

  49. Greaney DJ, Benson P. Life-threatening lactation or “bovine” ketoacidosis: a case report. A A Case Rep. 2016;7:81–4.

    PubMed  Google Scholar 

  50. Heffner AC, Johnson DP. A case of lactation “bovine” ketoacidosis. J Emerg Med. 2008;35:385–7.

    PubMed  Google Scholar 

  51. Hudak SK, Overkamp D, Wagner R, Haring HU, Heni M. Ketoacidosis in a non-diabetic woman who was fasting during lactation. Nutr J. 2015;14:117.

    PubMed  PubMed Central  Google Scholar 

  52. Monnier D, Goulenok T, Allary J, Zarrouk V, Fantin B. Starvation ketosis in a breastfeeding woman. Rev Med Interne. 2015;36:854–8.

    PubMed  CAS  Google Scholar 

  53. Nnodum BN, Oduah E, Albert D, Pettus M. Ketogenic diet-induced severe ketoacidosis in a lactating woman: a case report and review of the literature. Case Rep Nephrol. 2019;2019:1214208.

    PubMed  PubMed Central  Google Scholar 

  54. Sandhu HS, Michelis MF, DeVita MV. A case of bovine ketoacidosis in a lactating woman. NDT Plus. 2009;2:278–9.

    PubMed  PubMed Central  Google Scholar 

  55. Seaton C, Sutherly K, Miller MA. Breastfeeding ketoacidosis: a rare but important diagnosis for emergency physicians to recognize. Am J Emerg Med. 2019;37:374.

    PubMed  Google Scholar 

  56. Szulewski A, Howes D, Morton AR. A severe case of iatrogenic lactation ketoacidosis. BMJ Case Rep. 2012;2012.

  57. Wuopio J, Schiborr R, Charalampakis G. Severe ketoacidosis in breastfeeding woman with low energy and carbohydrate intake. Lakartidningen. 2015;112.

  58. Reader D, Franz MJ. Lactation, diabetes, and nutrition recommendations. Curr Diab Rep. 2004;4:370–6.

    PubMed  Google Scholar 

  59. Pedersen-Bjergaard U, Pramming S, Thorsteinsson B. Recall of severe hypoglycaemia and self-estimated state of awareness in type 1 diabetes. Diabetes Metab Res Rev. 2003;19:232–40.

    PubMed  Google Scholar 

  60. Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, et al. Clinical targets for continuous glucose monitoring data interpretation: recommendations from the International Consensus on Time in Range. Diabetes Care. 2019;42:1593–603.

    PubMed  Google Scholar 

  61. Nielsen LR, Ekbom P, Damm P, Glumer C, Frandsen MM, Jensen DM, et al. HbA1c levels are significantly lower in early and late pregnancy. Diabetes Care. 2004;27:1200–1.

    PubMed  CAS  Google Scholar 

  62. American Diabetes Association: Management of diabetes in pregnancy: standards of medical care in diabetes. Diabetes Care. 2020;43:S183–92.

  63. Spencer JP, Gonzalez LS III, Barnhart DJ. Medications in the breast-feeding mother. Am Fam Physician. 2001;64:119–26.

    PubMed  CAS  Google Scholar 

  64. Whitmore TJ, Trengove NJ, Graham DF, Hartmann PE. Analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus. Int J Endocrinol. 2012;2012:296368.

    PubMed  PubMed Central  CAS  Google Scholar 

  65. Hale’s Medications & mothers’ milk. Pages 387-9. 2020. New York, Springer Publishing Company.

  66. Ringholm L, Damm P, Mathiesen ER. Improving pregnancy outcomes in women with diabetes mellitus: modern management. Nat Rev Endocrinol. 2019;15:406–16.

    PubMed  Google Scholar 

  67. European Medicines Agency Novorapid label. https://www.ema.europa.eu/documents/product-information/novorapid-epar-product-information_en.pdf. https://www.ema.europa.eu/documents/product-information/novorapid-epar-product-information_en.pdf. Accessed January 8th 2020.

  68. European Medicines Agency Degludec label. https://www.ema.europa.eu/en/documents/product-information/tresiba-epar-product-information_en.pdf. Accessed January 8th 2020.

  69. European Medicines Agency Detemir Label. https://www.ema.europa.eu/en/documents/product-information/levemir-epar-product-information_en.pdf. Accessed January 8th 2020.

  70. European Medicines Agency Abasaglar label. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002835/WC500175381.pdf. Accessed January 8th 2020.

  71. European Medicines Agency Apidra label. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000557/WC500025250.pdf. Accessed January 8th 2020.

  72. European Medicines Agency FiAsp label. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004046/WC500220890.pdf. Accessed January 8th 2020.

  73. European Medicines Agency Lantus label. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000284/WC500036082.pdf. Accessed January 8th 2020.

  74. European Medicines Agency Lispro label. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004303/WC500235294.pdf. Accessed January 8th 2020.

  75. European Medicines Agency Toujeo label. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000309/WC500047935.pdf. Accessed January 8th 2020.

  76. Ringholm NL, Juul A, Pedersen-Bjergaard U, Thorsteinsson B, Damm P, Mathiesen ER. Lower levels of circulating IGF-I in type 1 diabetic women with frequent severe hypoglycaemia during pregnancy. Diabet Med. 2008;25:826–33.

    Google Scholar 

  77. • Keller MF, Vestgaard M, Damm P, Mathiesen ER, Ringholm L. Treatment with the long-acting insulin analog degludec during pregnancy in women with type 1 diabetes: an observational study of 22 cases. Diabetes Res Clin Pract. 2019;152:58–64. An observational study in 22 women with type 1 diabetes treated with insulin degludec from pre-conception until early after delivery. Women were advised to pause insulin degludec the first day after delivery. No events with severe hypoglycemia were reported during breastfeeding in the first days after delivery.

    PubMed  CAS  Google Scholar 

  78. Polsky S, Wu M, Bode BW, DuBose SN, Goland RS, Maahs DM, et al. Diabetes technology use among pregnant and nonpregnant women with T1D in the T1D exchange. Diabetes Technol Ther. 2018;20:517–23.

    PubMed  CAS  Google Scholar 

  79. Mathiesen JM, Secher AL, Ringholm L, Norgaard K, Hommel E, Andersen HU, et al. Changes in basal rates and bolus calculator settings in insulin pumps during pregnancy in women with type 1 diabetes. J Matern Fetal Neonatal Med. 2014;27:724–8.

    PubMed  CAS  Google Scholar 

  80. Abraham MB, Nicholas JA, Smith GJ, Fairchild JM, King BR, Ambler GR, et al. Reduction in hypoglycemia with the predictive low-glucose management system: a long-term randomized controlled trial in adolescents with type 1 diabetes. Diabetes Care. 2018;41:303–10.

    PubMed  Google Scholar 

  81. Battelino T, Nimri R, Dovc K, Phillip M, Bratina N. Prevention of hypoglycemia with predictive low glucose insulin suspension in children with type 1 diabetes: a randomized controlled trial. Diabetes Care. 2017;40:764–70.

    PubMed  CAS  Google Scholar 

  82. Aberer F, Hajnsek M, Rumpler M, Zenz S, Baumann PM, Elsayed H, et al. Evaluation of subcutaneous glucose monitoring systems under routine environmental conditions in patients with type 1 diabetes. Diabetes Obes Metab. 2017;19:1051–5.

    PubMed  CAS  Google Scholar 

  83. Buckingham BA, Bailey TS, Christiansen M, Garg S, Weinzimer S, Bode B, et al. Evaluation of a predictive low-glucose management system in-clinic. Diabetes Technol Ther. 2017;19:288–92.

    PubMed  CAS  Google Scholar 

  84. Rooney BL, Schauberger CW. Excess pregnancy weight gain and long-term obesity: one decade later. Obstet Gynecol. 2002;100:245–52.

    PubMed  Google Scholar 

  85. Janney CA, Zhang D, Sowers M. Lactation and weight retention. Am J Clin Nutr. 1997;66:1116–24.

    PubMed  CAS  Google Scholar 

  86. Mathiesen ER. Pregnancy outcomes in women with diabetes-lessons learned from clinical research: the 2015 Norbert Freinkel Award Lecture. Diabetes Care. 2016;39:2111–7.

    PubMed  CAS  Google Scholar 

  87. Krause KM, Lovelady CA, Peterson BL, Chowdhury N, Ostbye T. Effect of breast-feeding on weight retention at 3 and 6 months postpartum: data from the North Carolina WIC Programme. Public Health Nutr. 2010;13:2019–26.

    PubMed  Google Scholar 

  88. Sichieri R, Field AE, Rich-Edwards J, Willett WC. Prospective assessment of exclusive breastfeeding in relation to weight change in women. Int J Obes Relat Metab Disord. 2003;27:815–20.

    PubMed  CAS  Google Scholar 

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Correspondence to Lene Ringholm.

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Conflict of Interest

Lene Ringholm reports a grant from Novo Nordisk for a clinical trial on insulin analogs.

Elisabeth Buur Stougaard and Sidse Kjærhus Nørgaard each declare no potential conflicts of interest.

Peter Damm is on an advisory board of a project concerning the use of insulin analogs in pregnancy. No personal fee is received, but his institution gets a small fee for this.

Elisabeth R. Mathiesen reports personal fees from Novo Nordisk for one time insulin trial and speaker’s fees.

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Ringholm, L., Stougaard, E.B., Nørgaard, S.K. et al. Diabetes Management During Breastfeeding in Women with Type 1 Diabetes. Curr Diab Rep 20, 34 (2020). https://doi.org/10.1007/s11892-020-01315-x

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