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Diabetic Dyslipidemia: Epidemiology and Prevention of Cardiovascular Disease and Implications of Newer Therapies

  • Diabetes and Cardiovascular Disease (ND Wong, Section Editor)
  • Published:
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Abstract

Purpose of Review

Dyslipidemia in patients with T2DM confers significant additional risk of adverse outcomes to patients with cardiovascular disease (CVD). These patients carry residual risk of adverse outcomes despite optimal management with conventional therapy such as lifestyle changes and statin therapy. The role of both nonstatin monotherapy in statin-intolerant patients and combination therapy with statins in patients with high risk of CVD events has been well studied. We sought to review the role of newer therapies in risk reduction in these patients.

Recent Findings

Traditionally, non-statin options have included medications such as niacin, ezetimibe, fenofibrate, and n-3 fatty acids. Recently, drugs such as ezetimibe, inclisiran, and PCSK9 inhibitors have been studied with favorable results without an increased risk of developing new-onset diabetes. These medications hold the promise of increasing options to reduce cardiovascular risk in patients with T2DM.

Summary

The role of newer non-statin therapies in patients with diabetic dyslipidemia in combination with statins needs to be further explored.

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Authors and Affiliations

  1. Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA

    Haider J. Warraich

  2. Division of Cardiology, Kaiser Permanente Medical Center, 3600 Broadway, Oakland, CA, 94611, USA

    Jamal S. Rana

  3. Department of Medicine, University of California San Francisco, San Francisco, CA, USA

    Jamal S. Rana

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  1. Haider J. Warraich
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Correspondence to Jamal S. Rana.

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Haider J. Warraich and Jamal S. Rana declare that they have no conflict of interest.

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This article is part of the Topical Collection on Diabetes and Cardiovascular Disease

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Warraich, H.J., Rana, J.S. Diabetic Dyslipidemia: Epidemiology and Prevention of Cardiovascular Disease and Implications of Newer Therapies. Curr Cardiol Rep 20, 125 (2018). https://doi.org/10.1007/s11886-018-1068-6

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