Abstract
Purpose of Review
With an increasing number of interventional procedures performed for structural heart disease and cardiac arrhythmias each year, echocardiographic guidance is necessary for safe and efficient results. The purpose of this review article is to overview the principles of intracardiac echocardiography (ICE) and describes the peri-interventional role of ICE in a variety of structural heart disease and electrophysiological interventions.
Recent Findings
Both transthoracic (TTE) and transesophageal echocardiography have limitations. ICE provides the advantage of imaging from within the heart, providing shorter image distances and higher resolution. ICE may be performed without sedation and avoids esophageal intubation as with transesophageal echocardiography (TEE). Limitations of ICE include the need for additional venous access with possibility of vascular complications, potentially higher costs, and a learning curve for new operators. Data supports the use of ICE in guiding device closure of interatrial shunts, transseptal puncture, and electrophysiologic procedures.
Summary
This paper reviews the more recent reports that ICE may be used for primary guidance or as a supplement to TEE in patients undergoing left atrial appendage (LAA) closure, interatrial shunt closure, transaortic valve implantation (TAVI), percutaneous mitral valve repair (PMVR), paravalvular leak (PVL) closure, aortic interventions, transcatheter pulmonary valve replacement (tPVR), ventricular septal defect (VSD), and patent ductus arteriosus (PDA) closure. ICE imaging technology will continue to expand and help improve structural heart and electrophysiology interventions.
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Abbreviations
- ASD:
-
Atrial septal defect
- CMC:
-
Circular marking catheter
- ICE:
-
Intracardiac echocardiography
- IPAI:
-
Intraluminal phased-array imaging
- LAA:
-
left atrial appendage
- PDA:
-
Patent Ductus Arteriousus
- PMBV:
-
percutaneous mitral balloon valvuloplasty
- PMVR:
-
percutaneous mitral valve repair
- PVL:
-
paravalvular leak
- tPVR:
-
transcatheter pulmonary valve replacement
- RT-3D:
-
Real-time three dimensional
- TAVI:
-
Transaortic valve implantation
- TEE:
-
Transesophageal echocardiography
- TTE:
-
Transthoracic echocardiography
- TS:
-
Transseptal
- VSD:
-
Ventricular Septal Defect
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Lung B, Vahanian A. Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol. 2011;8:162–72.
D’Arcy JL, Prendergast BD, Chambers JB, Ray SG, Bridgewater B. Valvular heart disease: the next cardiac epidemic. Heart. 2011;97:91–3.
Kronzon I, Glassman E, Cohen M, Winer H. Use of two-dimensional echocardiography during transseptal cardiac catheterization. J Am Coll Cardiol. 1984;4:425–8.
Faletra FF, Pedrazzini G, Pasotti E, Muzzarelli S, Dequarti MC, Murzilli R, et al. 3D TEE during catheter-based interventions. JACC Cardiovasc Imaging. 2014;7(3):292–308.
Mathur SK, Singh P. Transoesophageal echocardiography related complications. Indian J Anaesth. 2009;53(5):567–74.
• Kliger C, Ignacio Cruz-Gonzalez B, Ruiz CE. The present and future of Intracardiac echocardiography for guiding structural heart disease interventions. Rev Esp Cardiol. 2012;65(9):791–4. Excellent review on intracardiac echocardiography for structural heart disease interventions
Eggleton RC, Townsend C, Kossoff G. Program and abstracts of the eighth ICBME, session 10–3., computerized ultrasonic visualization of dynamic ventricular configuration. Chicago: Palmer House; 1969.
Glassman E, Kronzon I. Transvenous intracardiac echocardiography. Am J Cardiol. 1981;47:1255–9.
•• Bartel T, Muller S, et al. Why is intracardiac echocardiography helpful? Benefits, costs, and how to learn. Eur Heart J. 2014;35(2):69–76. Excellent review on intracardiac echocardiography
Rashkind WJ, Miller WW. Creation of an atrial septal defect without thoracotomy. A palliative approach to complete transposition of the great arteries. JAMA. 1966;196:991–2.
Hahn K, Gal R, Sarnoski J, Kubota J, Schmidt DH, Bajwa TK. Transesophageal echocardiographically guided atrial transseptal catheterization in patients with normal-sized atria: incidence of complications. Clin Cardiol. 1995;18:217–20.
Ren JF, Marchlinski FE. Superiority of simulator-based training compared with conventional training methodologies in the performance of transseptal catheterization. J Am Coll Cardiol. 2012;59(3):291–2.
Laura DM, et al. Lipomatous atrial septal hypertrophy: a review of its anatomy, pathophysiology, multimodality imaging, and relevance to percutaneous interventions. J Am Soc Echocardiogr. 2016;29(8):717–23.
Bayrak CG-B, Namdar M, et al. Added value of transoesophageal echocardiography during transseptal puncture performed by inexperienced operators. Europace. 2012;14:661–5.
Daoud EG, Kalbfleisch SJ, Hummel JD. Intracardiac echocardiography to guide transseptal left heart catheterization for radiofrequency catheter ablation. J Cardiovasc Electrophysiol. 1999;10(3):358–63.
Epstein LM, Smith T, TenHoff H. Nonfluoroscopic transseptal catheterization: safety and efficacy of intracardiac echocardiographic guidance. J Cardiovasc Electrophysiol. 1998;9(6):625–30.
Calò L, Lamberti F, Loricchio ML, D’Alto M, Castro A, Boggi A, et al. Intracardiac echocardiography: from electroanatomic correlation to clinical application in interventional electrophysiology. Ital Heart J. 2002;3(7):387–98.
Bazaz R, Schwartzman D. Site-selective atrial septal puncture. J Cardiovasc Electrophysiol. 2003;14:196–9.
Akkaya E, Vuruskan E, Zorlu A, Sincer I, Kucukosmanoglu M, Ardic I, et al. Aortic intracardiac echocardiography-guided septal puncture during mitral valvuloplasty. Eur Heart J Cardiovasc Imaging. 2014;15(1):70–6.
Mullen MJ, Dias BF, Walker F, Siu SC, Benson LN, McLaughlin PR. Intracardiac echocardiography guided device closure of atrial septal defects. J Am Coll Cardiol. 2003;41:285–92.
Hijazi Z, Wang Z, Cao Q, Koenig P, Waight D, Lang R. Transcatheter closure of atrial septal defects and patent foramen ovale under intracardiac echocardiographic guidance: feasibility and comparison with transesophageal echocardiography. Catheter Cardiovasc Interv. 2001;52(2):194–9.
Medford BA, Taggart NW, Cabalka AK, Cetta F, Reeder GS, Hagler DJ, et al. Intracardiac echocardiography during atrial septal defect and patent foramen ovale device closure in pediatric and adolescent patients. J Am Soc Echocardiogr. 2014;27(9):984–90.
ASE’s comprehensive echocardiography 2nd Edition. Lang RM, Goldstein SA, Kronzon I, Khandheria BK, Mor-Avi V. Elsevier Publishing. Philadelphia, PA 19103.
Zhoa J et al. Safe and effective guidance by intracardiac echocardiography for transcatheter closure in atrial septal defects. International Journal Clinical Exp Med. 2015.
Rigatelli G, Dell’Avvocata F, Cardaioli P, Giordan M, Braggion G, Aggio S, et al. Five-year follow-up of transcatheter intracardiac echocardiography-assisted closure of interatrial shunts. Cardiovasc Revasc Med. 2011;12(6):355–61.
Assaidi A, Sumian M, Mauri L, Mancini J, Ovaert C, Salaun E, et al. Transcatheter closure of complex atrial septal defects is efficient under intracardiac echocardiographic guidance. Arch Cardiovasc Dis. 2014 Dec;107(12):646–53.
Boccalandro F, Baptista E, Muench A, Carter C, Smalling RW. Comparison of intracardiac echocardiography versus transesophageal echocardiography guidance for percutaneous transcatheter closure of atrial septal defect. Am J Cardiol. 2004;93:437–40.
Alboliras ET, Hijazi ZM. Comparison of costs ofintracardiac echocardiography and transesophageal echocardiography in monitoring percutaneous device closure of atrial septal defect in children and adults. Am J Cardiol. 2004;94:690–2.
Bartel T, Bonaros N, Edlinger M, Velik-Salchner C, Feuchtner G, Rudnicki M, et al. Intracardiac echo and reduced radiocontrast requirements during TAVR. JACC Cardiovasc Imaging. 2014;7(3):319–20.
Bartel T, Konorza T, Arjumand J, Ebradlidze T, Eggebrecht H, Caspari G, et al. Intracardiac echocardiography is superior to conventional monitoring for guiding closure of interatrial communications. Circulation. 2003;107:795–7.
Saliba W, Thomas J. Intracardiac echocardiography during catheter ablation of atrial fibrillation. Europace. 2008;10(Suppl 3):iii42–7.
Kalman JM, Fitzpatrick AP, Olgin JE, et al. Biophysical characteristics of radiofrequency lesion formation in vivo : dynamics of catheter tip–tissue contact evaluated by intracardiac echocardiography. Am Heart J. 1997;133:8–18.
Kanj M, Wazni O, Natale A. Pulmonary vein antrum isolation. Heart Rhythm. 2007;4:S73–9.
Bhatia NL, Humphries J, Chandrasekaran K, Srivathsan K. Atrial fibrillation ablation in cor triatriatum: value of intracardiac echocardiography. J Interv Card Electrophysiol. 2010;28(2):153–5.
Barker PC. Intracardiac echocardiography in congenital heart disease. J Cardiovasc Transl Res. 2009;2(1):19–23.
Horowitz BN, Vaseghi M, Mahajan A, Cesario DA, Buch E, Valderrabano M, et al. Percutaneous intrapericardial echocardiography during catheter ablation: a feasibility study. Heart Rhythm. 2006.
Filgueiras-Rama D, de Torres-Alba F, Castrejón-Castrejón S, Estrada A, Figueroa J, Salvador-Montañés Ó, et al. Utility of intracardiac echocardiography for catheter ablation of complex cardiac arrhythmias in a medium-volume training center. Echocardiography. 2015;32(4):660–70.
Shah SJ, Bardo DM, Sugeng L, Weinert L, Lodato JA, Knight BP, et al. Real-time three-dimensional transesophageal echocardiography of the left atrial appendage: initial experience in the clinical setting. J Am Soc Echocardiogr. 2008;21(12):1362–8. https://doi.org/10.1016/j.echo.2008.09.024.
Rao, et al. ICE-CHIP study. J Interv Card Electrophysiol. 2005;13(Suppl 1):31–6.
Ren JF, Marchlinsky FE, Supple GE, Hutchinson MD, Garcia FC, Riley MP, et al. Intracardiac echocardiographic diagnosis of thrombus formation in the left atrial appendage: a complementary role to transesophageal echocardiography. Echocardiography. 2013;30:72–80.
Anter E, Silverstein J, Tschabrunn CM, Shvilkin A, Haffajee CI, Zimetbaum PJ, et al. Comparison of intracardiac echocardiography and transesophageal echocardiography for imaging of the right and left atrial appendages. Heart Rhythm. 2014;11(11):1890–7.
Berti S, Paradossi U, Meucci F, Trianni G, Tzikas A, Rezzaghi M, et al. Periprocedural intracardiac echocardiography for left atrial appendage closure: a dual-center experience. JACC Cardiovasc Interv. 2014;7:1036–44.
Matsuo Y, Neuzil P, Petru J, Chovanec M, Janotka M, Choudry S, et al. Left atrial appendage closure under intracardiac echocardiographic guidance: feasibility and comparison with transesophageal echocardiography. J Am Heart Assoc. 2016;28:5(10).
• Kronzon I, Jelnin V, Ruiz CE, et al. Optimal imaging for guiding TAVR: transesophageal or transthoracic echocardiography, or just fluoroscopy? J Am Coll Cardiol Img. 2015:361–70. Paper describes different imaging options for TAVR guidance. The paper includes benefits and drawbacks to several imaging modalities
Bartel T, Bonaros N, Müller L, Friedrich G, Grimm M, Velik-Salchner C, et al. Intracardiac echocardiography: a new guiding tool for transcatheter aortic valve replacement. J Am Soc Echocardiogr. 2011;24(9):966–75.
Bartel T, Edris A, Velik-Salchner C, Müller S. Intracardiac echocardiography for guidance of transcatheter aortic valve implantation under monitored sedation: a solution to a dilemma? Eur Heart J Cardiovasc Imaging. 2016;17(1):1–8.
Bartel T, Bonaros N, Edlinger M, Velik-Salchner C, Feuchtner G, Rudnicki M, et al. Lower risk of severe acute kidney injury in transcatheter aortic valve replacement: intracardiac echocardiography yields reduction of radio-contrast medium requirements. JACC Cardiovasc Imaging. 2014 Mar;7(3):319–20.
Müller S, Velik-Salchner C, Edlinger M, Bonaros N, Heinz A, Feuchtner G, et al. Intracardiac Doppler echocardiography for monitoring of pulmonary artery pressures in high-risk patients undergoing transcatheter aortic valve replacement. J Am Soc Echocardiogr. 2016;29(1):83–91.
Rendon A, Hamid T et al.. Annular sizing using real-time three-dimensional intracardiac echocardiography-guided trans-catheter aortic valve replacement. Open Heart. 2016;3(1).
Principles of Echocardiography and Intracardiac Echocardiography. Stuart J. Hutchison MD. Elsevier. 2012.
Altiok E, Becker M, Hamada S, Grabskaya E, Reith S, Marx N, et al. Real-time 3D TEE allows optimized guidance of percutaneous edge-to-edge repair of the mitral valve. JACC Cardiovasc Imaging. 2010;11:1196–8.
Altiok E, Hamada S, Brehmer K, Kuhr K, Reith S, Becker M, et al. Analysis of procedural effects of percutaneous edge-to-edge mitral valve repair by 2D and 3D echocardiography. Circ Cardiovasc Imaging. 2012;6:748–55.
Patzelt J, Seizer P, Zhang YY, Walker T, Schreieck J, Gawaz M, et al. Percutaneous mitral valve edge-to-edge repair with simultaneous Biatrial Intracardiac echocardiography: first-in-human experience. Circulation. 2016;133:1517–9.
Grassi G, Barbierato M, Pascotto A, Ronco F, Postorino S, Millosevich P, et al. Role of intracardiac echocardiography during percutaneous edge-to-edge mitral valve repair with the MitraClip system: a single center experience. Eur Secur. 2011;7(supplement M):395.
Henning A, Mueller II, Mueller K, Zuern C, Walker T, Gawaz M, et al. Percutaneous edge-to-edge mitral valve repair escorted by left atrial intracardiac echocardiography (ICE). Circulation. 2014;130(Issue 20):e173–4.
Saji M, Rossi AM, Ailawadi G, Dent J, Ragosta M, Lim DS. Adjunctive intracardiac echocardiography imaging from the left ventricle to guide percutaneous mitral valve repair with the MitraClip in patients with failed prior surgical rings. Catheter Cardiovasc Interv. 2016;87(2):E75–82.
Green NE, Hansgen AR, Carroll JD. Initial clinical experience with intracardiac echocardiography in guiding balloon mitral valvuloplasty: technique, safety, utility, and limitations. Catheter Cardiovasc Interv. 2004;63(3):385–94.
Ahmari SA, Amro A, Otabi MA, Abdullah MA, Kasab SA, Amri HA. Initial experience of using intracardiac echocardiography (ICE) for guiding balloon mitral valvuloplasty (BMV). J Saudi Heart Assoc. 2012;24(1):23–7.
Marmagkiolis K, Cilingiroglu M. Intracardiac echocardiography guided percutaneous mitral balloon valvuloplasty. Rev Port Cardiol. 2013;32:337–9.
Kronzon I, Sugeng L, Perk G, et al. Real-time 3-dimensional transesophageal echocardiography in the evaluation of post-operative mitral annuloplasty ring and prosthetic valve dehiscence. J Am Coll Cardiol. 2009;53:1543–7.
Bavikati VV, Babaliaros VC, Lerakis S. Utility of threedimensional echocardiography in percutaneous closure of paravalvular leak. Echocardiography. 2009;26:852–4.
Deftereos S, Giannopoulos G, Raisakis K, et al. Intracardiac echocardiography imaging of periprosthetic valvular regurgitation. Eur J Echocardiogr. 2010;11:E20.
Rihal CS, Sorajja P, Booker JD, Hagler DJ, Cabalka AK. Principles of percutaneous paravalvular leak closure. JACC Cardiovasc Interv. 2012;5:121–30.
Cappelli F, Del Bene MR, Santoro G, Meucci F, Attanà P, Barletta G. The challenge of integrated echocardiographic approach in percutaneous closure of paravalvular leak. Echocardiography. 2011;28(8):E168–71.
Osman F, Steeds R. Use of intra-cardiac ultrasound in the diagnosis of prosthetic valve malfunction. Eur J Echocardiogr. 2007;8:392–4.
Sharma M, Tseng E, Schiller N, Moore P, Shunk KA. Closure of aortic paravalvular leak under intravascular ultrasound and intracardiac echocardiography guidance. J Invasive Cardiol. 2011;23(1):E250.
Chessa M, Butera G, Carminati M. Intracardiac echocardiography during percutaneous pulmonary valve replacement. Eur Heart J. 2008;29:2908.
Awad SM, Masood SA, Gonzalez I, Cao QL, Abdulla RI, Heitschmidt MG, et al. The use of intracardiac echocardiography during percutaneous pulmonary valve replacement. Pediatr Cardiol. 2015;36(1):76–83.
Whiteside W, Pasquali SK, Yu S, Bocks ML, Zampi JD, Armstrong AK. The utility of Intracardiac echocardiography following Melody™ transcatheter pulmonary valve implantation. Pediatr Cardiol. 2015;36(8):1754–60.
Evangelista A, et al. Echocardiography in aortic diseases: EAE recommendations for clinical practice. Eur J Echocardiogr. 2010;11(8):645–58.
Kronzon I, Chen C, Chinitz LA, Bernstein NE, Slater JN, Varkey M, et al. Evaluation of the abdominal aorta and the renal arteries with an intracardiac echocardiography probe placed in the inferior vena cava: a feasibility study. J Am Soc Echocardiogr. 2007;20(2):119–25.
Bartel T, Eggebrecht H, Müller S, Gutersohn A, Bonatti J, Pachinger O, et al. Comparison of diagnostic and therapeutic value of transesophageal echocardiography, intravascular ultrasound imaging, and intraluminal phased-array imaging in aortic dissection with tear in the descending thoracic aorta (type B). Am J Cardiol. 2007;99:270–4.
Grabenwöger M, Alfonso F, Bachet J, Bonser R, Czerny M, Eggebrecht H, et al. Thoracic endovascular aortic repair (TEVAR) for the treatment of aortic diseases: a position statement from the European Association for Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2012;33(13):1558–63.
Teramachi Y, Suda K, Yoshimoto H, et al. Trans-pulmonary echocardiography to guide stent implantation into coarctation of the aorta. Echocardiography. 2015;32:872–4.
George JC, Varghese V, Mogtader A. Intracardiac echocardiography: evolving use in interventional cardiology. J Ultrasound Med. 2014 Mar;33(3):387–95.
Cao QL, Zabal C, Koenig P, Sandhu S, Hijazi ZM. Initial clinical experience with intracardiac echocardiography in guiding transcatheter closure of perimembranous ventricular septal defects: feasibility and comparison with transesophageal echocardiography. Catheter Cardiovasc Interv. 2005;66(2):258–67.
Kudo Y, Suda K, Yoshimoto H, Teramachi Y, Kishimoto S, Lemura M, et al. Trans-pulmonary echocardiography as a guide for device closure of patent ductus arteriosus. Catheter Cardiovasc Interv. 2015;86(2):264–70.
Bartel T, Gliech V, Müller S. Device closure of patent ductus arteriosus: optimal guidance by transaortic phased-array imaging. Eur J Echocardiogr. 2011;12:E9.
Wildes D, Lee W, Haider B et al.. 4D ICE: a 2D array transducer with integrated ASIC in a 10 Fr catheter for real-time 3D intracardiac echocardiography. IEEE Trans Ultrason Ferroelectr Freq Control. 2016;12.
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Craig Basman, Yuvrajsinh J. Parmar, and Itzhak Kronzon declare that they have no conflict of interest.
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Basman, C., Parmar, Y.J. & Kronzon, I. Intracardiac Echocardiography for Structural Heart and Electrophysiological Interventions. Curr Cardiol Rep 19, 102 (2017). https://doi.org/10.1007/s11886-017-0902-6
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DOI: https://doi.org/10.1007/s11886-017-0902-6