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Precision Medicine in Rhinosinusitis

  • Rhinosinusitis (J Mullol, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Our scope is the presentation of research and clinical progresses in relation to precision medicine that are expected to alter our clinical practice in relation to chronic rhinosinusitis (CRS). Current knowledge on phenotypes and endotypes, biomarkers, and clinical markers for diagnosis, medical and surgical therapy, and prognosis is presented as well as the role of precision medicine in United Airway Disease and SCUAD (severe-uncontrolled chronic upper airway inflammation).

Recent Findings

Current technological progresses, mostly in relation to molecular biology and information technology, have permitted more detailed pathophysiological assessments and multidimensional approaches in airways diseases. Based on the concept of united airways diseases, new classification schemes, called endotypes, have been proposed for CRS. In addition, novel biological treatments that have been introduced for the treatment of asthma show great promise as well for severe uncontrolled cases of CRS with nasal polyps. Central to this approach are new biomarkers that are being examined in relation to complex bio-clinical traits of CRS.

Summary

As this narrative review of the aforementioned precision medicine initiatives in relation to CRS advances, a modification of current practice is expected not only for severe chronic upper airways diseases in tertiary centers but also for milder and more common cases that are being encountered in the community.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Author information

Authors and Affiliations

  1. ENT Private Practice, 29 Voreiou Ipeirou str, Athens, Greece

    Ioannis Vlastos

  2. Embiodiagnostics Biology Research Company, Melissinon and Damvergidon str, Heraklion, Crete, Greece

    Kalliopi Gkouskou

  3. Department of Otorhinolaryngology, University Hospital of Crete, A Building 3rd Floor, University avenue, 71110, Heraklion, Crete, Greece

    Maria Doulaptsi & Emmanuel P. Prokopakis

  4. Department of Otorhinolaryngology, University of Crete School of Medicine, Heraklion, Crete, Greece

    Alexander Karatzanis & Emmanuel P. Prokopakis

Authors
  1. Ioannis Vlastos
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  2. Kalliopi Gkouskou
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  3. Maria Doulaptsi
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  4. Alexander Karatzanis
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  5. Emmanuel P. Prokopakis
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Corresponding author

Correspondence to Emmanuel P. Prokopakis.

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Conflict of Interest

Dr. Kalliopi Gkouskou is the founder of Embiodiagnostics, a research company in the field of precision medicine. More specifically, it owns Genosophy-Discover Yourself, a genotyping test that is mostly related to Nutrigenetics field. Nevertheless, it does not sell/promote any of the medications or the biomarkers reported in the manuscript. The other authors declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Rhinosinusitis

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Vlastos, I., Gkouskou, K., Doulaptsi, M. et al. Precision Medicine in Rhinosinusitis. Curr Allergy Asthma Rep 19, 12 (2019). https://doi.org/10.1007/s11882-019-0850-x

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  • DOI: https://doi.org/10.1007/s11882-019-0850-x

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