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From 2000 to 2016: Which Second-Line Treatment in Advanced Non-Small Cell Lung Cancer?

  • Lung Cancer (HA Wakelee, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

An Erratum to this article was published on 20 December 2016

Opinion statement

New treatments—as immunotherapies and new antiangiogenic agents—are now available in second-line setting for patients affected by EGFR wild-type and ALK-negative non-small-cell lung cancer (NSCLC). Nintedanib, ramucirumab, nivolumab and pembrolizumab have to be included in the therapeutic sequences for patients affected by NSCLC, but no clear selection criteria are to date offered, except for patients with PD-L1 expression ≥50 %. Performance status, smoking habits and comorbidities should be considered as clinical criteria in order to select the appropriate treatment, but also tumour characteristics as histotype, platinum resistance and rapid progression after a first-line therapy should be taken into account. The aim of the present paper is to identify subgroups of patients eligible for different therapy sequences.

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Authors and Affiliations

  1. Department of Medical Oncology, Catholic University of Sacred Heart, Largo A. Gemelli, 8, 00168, Rome, Italy

    Ettore D’Argento MD, PhD, Giovanni Schinzari MD, PhD, Antonia Strippoli MD, PhD, Michele Basso MD, PhD, Alessandra Cassano MD, PhD & Carlo Barone MD, PhD

  2. Department of Medical Oncology, Humanitas Clinical and Research Center, Via Manzoni, 56, 20089, Rozzano, MI, Italy

    Sabrina Rossi MD

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  1. Ettore D’Argento MD, PhD
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  4. Antonia Strippoli MD, PhD
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Correspondence to Sabrina Rossi MD.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Lung Cancer

An erratum to this article is available at http://dx.doi.org/10.1007/s11864-016-0441-1.

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D’Argento, E., Rossi, S., Schinzari, G. et al. From 2000 to 2016: Which Second-Line Treatment in Advanced Non-Small Cell Lung Cancer?. Curr. Treat. Options in Oncol. 17, 59 (2016). https://doi.org/10.1007/s11864-016-0437-x

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