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Liraglutide combined with metformin treatment for obese people with type 2 diabetes mellitus: a systematic review and meta-analysis

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Abstract

Aim

To assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs).

Methods

PubMed, EMBASE, Cochrane Library, CNKI, CNKI, and VIP databases were systematically searched for randomized controlled trials (RCTs) through January 1, 2015 to investigate the effectiveness of liraglutide combined with metformin treatment (LMT) in obesity patients with type 2 diabetes (ODP). Meta-analysis (using generic inverse variance random effects model) was performed when there were two or more studies reporting on the same evaluation indicators. Review Manager V.5.3 was used to perform the meta-analysis.

Results

A total of 1289 participants from 15 RCTs were selected for the final meta-analysis. A synthesis of current evidence of LMT for treating ODP was provided in this protocol.

Conclusion

This review will offer insights for future research and provide reference for LMT treatment for ODP.

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Data Availability

Data available on request from the authors.

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Funding

This work was supported by the Chengdu Philosophy and Social Science Planning Project (No. 2022BZ157).

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Authors and Affiliations

  1. Department of Pharmacy, Jintang First People’s Hospital (West China Hospital Sichuan University Jintang Hospital), Chengdu, 610041, People’s Republic of China

    Yang Long

  2. Affiliated Hospital of Sichuan Nursing Vocational College, The Third People’s Hospital of Sichuan Province, Chengdu, 610199, People’s Republic of China

    Yuxi Zhang

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  1. Yang Long
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Correspondence to Yuxi Zhang.

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The study received ethics approval from Jintang First People’s Hospital. There are no sensitive data, and no patients were recruited for this study.

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The authors declare no competing interests.

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Long, Y., Zhang, Y. Liraglutide combined with metformin treatment for obese people with type 2 diabetes mellitus: a systematic review and meta-analysis. Ir J Med Sci 192, 2809–2814 (2023). https://doi.org/10.1007/s11845-023-03337-2

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  • DOI: https://doi.org/10.1007/s11845-023-03337-2

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