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The development of extraintestinal manifestation and related risk factors in Crohn’s patients

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Background

Crohn’s disease (CD) primarily involves gastrointestinal tract; however, it can present with extraintestinal manifestations (EIMs), which leads to significant morbidity. Frequency of EIMs and associated risk factors vary due to genetic and environmental differences in studies.

Aim

To examine the frequency and risk factors associated with EIMs in CD.

Method

Patients with CD under follow-up from March 1986 to October 2011 were included in this study. Demographics, type of EIMs, autoimmune diseases, and clinical features of CD were recorded. Frequency of EIMs and associated risk factors were analyzed.

Results

Three hundred thirty-six patients with CD were included in the study (mean follow-up duration 7.54 years). 55.4% (n: 186) were male and the mean age at diagnosis of CD was 30.6 years (range, 10.3–68.2 years). At least one EIM was detected in 47.3% and multiple EIMs in 22.9% of the cohort. Oral, joint, and skin involvements (32.4%, 24.7%, 9.2%, respectively) were the most common EIMs. Female gender (OR: 2.19, 95% CI: 1.34–3.58, p = 0.001), corticosteroid usage (OR: 2.32, 95% CI: 1.28–4.22, p = 0.007), and positive family history (OR: 5.61, 95% CI: 1.95–3.58, p = 0.001) were independent risk factors for EIM development. Colonic involvement (OR: 3.93, 95% CI: 1.59–9.68, p = 0.003), no surgical operation (OR: 2.31, 95% CI: 1.14–4.68, p = 0.020), and corticosteroid usage (OR: 2.85, 95% CI: 1.07–7.61, p = 0.037) were independent risk factors for multiple EIM development.

Conclusion

Although the immunological and clinical associations between EIMs and CD cannot be fully elucidated, identifying specific relationships of immune-mediated diseases will help to better understand CD pathogenesis.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, Van Education and Research Hospital, Saglik Bilimleri University, 65100, Van, Turkey

    Yusuf Kayar & Ramazan Dertli

  2. Department of Internal Medicine, Van Education and Research Hospital, Saglik Bilimleri University, Van, Turkey

    Sevki Konur

  3. Department of Pediatry, Division of Gastroenterology, Van Education and Research Hospital, Saglik Bilimleri University, Van, Turkey

    Mehmet Agin

  4. Department of Internal Medicine, Division of Gastroenterology, Koç University, Istanbul, Turkey

    Bulent Baran

  5. Department of Internal Medicine, Division of Gastroenterology, Istanbul University, Istanbul, Turkey

    Asli Ciftcibasi Ormeci, Filiz Akyuz, Kadir Demir, Fatih Besisik & Sabahattin Kaymakoglu

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  1. Yusuf Kayar
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Correspondence to Yusuf Kayar.

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Ethical approval for this study was obtained from the Ethics Committee of our institution (Turkey). Principles of Declaration of Helsinki and ethical standards of our institution’s human experimentation committee were followed.

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Kayar, Y., Dertli, R., Konur, S. et al. The development of extraintestinal manifestation and related risk factors in Crohn’s patients. Ir J Med Sci 190, 597–604 (2021). https://doi.org/10.1007/s11845-020-02326-z

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  • DOI: https://doi.org/10.1007/s11845-020-02326-z

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