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Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients

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Abstract

Background

This study is aimed at exploring the correlation of sirtuin 2 (SIRT2) with clinical characteristics as well as overall survival (OS) in breast cancer patients.

Methods

Totally, 296 primary breast cancer patients who underwent surgical resection were retrospectively reviewed in this study, and SIRT2 expression in tumor and adjacent tissues was determined by immunohistochemistry (IHC) and scored by semiquantitative scoring (0–12). Clinicopathological features were retrieved, and OS was calculated.

Results

Both SIRT2 IHC semiquantitative score and percentage of SIRT2 high expression by IHC score > 3 were lower in tumor tissues compared with adjacent tissues. Additionally, tumor SIRT2 high expression was associated with lower T stage, decreased N stage, and reduced TNM stage. Kaplan-Meier curves displayed that tumor SIRT2 high expression predicted longer OS. Univariate Cox’s regression analysis showed that tumor SIRT2 high expression was associated with prolonged OS, while multivariate Cox’s regression analysis displayed that tumor SIRT2 high expression was not an independent predictive factor for OS, which implied that tumor SIRT2 might predict OS indirectly through the interaction of tumor features (such as TNM stage) in breast cancer patients.

Conclusion

SIRT2 expression is lower in tumor tissues compared with adjacent tissues, and tumor SIRT2 high expression correlates with lower T stage, decreased N stage, reduced TNM stage, and longer OS in breast cancer patients.

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Author notes

  1. Pengfei Shi and Min Zhou contributed equally to this work.

Authors and Affiliations

  1. Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street Jiangan District, Wuhan, 430014, China

    Pengfei Shi & Yonggang Yang

  2. Department of Out-patient, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Min Zhou

Authors
  1. Pengfei Shi
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  2. Min Zhou
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  3. Yonggang Yang
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Corresponding author

Correspondence to Yonggang Yang.

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The Ethical Committee of our hospital approved the protocol of this study. All enrolled patients or their guardians provided written informed consents or verbal agreements with recording.

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The authors declare that they have no competing interests.

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Shi, P., Zhou, M. & Yang, Y. Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients. Ir J Med Sci 189, 83–89 (2020). https://doi.org/10.1007/s11845-019-02071-y

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  • DOI: https://doi.org/10.1007/s11845-019-02071-y

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