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Pyogenic liver abscesses due to Escherichia coli are still related to worse outcomes

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Abstract

Background

In western countries, there has been a gradual shift from Escherichia coli to Klebsiella pneumoniae as an emerging pathogen isolated from pyogenic liver abscesses (PLA).

Aims

To compare outcomes between patients with Escherichia coli liver abscesses and non–Escherichia coli liver abscesses in terms of mortality.

Methods

One hundred nine-three consecutive hospital admissions of Pyogenic liver abscesses were analyzed, mean age 66.9 years old (± 13.6), 112 men (58%). The sample was divided into two groups: E. coli liver abscesses and non–E. coli liver abscesses. The etiologic, clinical, and microbiologic characteristics; therapeutic options; and outcomes, in terms of morbidity and mortality, between E. coli and non–E. coli liver abscesses were compared. In-hospital mortality, as outcome variable, was analyzed in a multivariate analysis.

Results

Fifty-seven episodes of PLA (29.5%) corresponded to E. coli infections, and 136 (70.5%) to non–E. coli infections. Patients with E. coli PLA were more likely to have jaundice, polymicrobial isolation (57.1% vs 21.6%, p < 0.001), biliary origin (71.9% vs 39%, p < 0.001), and septic shock (38.6% vs 12.5%, p < 0.001). Antibiotic therapy alone, without percutaneous drainage, was less common in the E. coli PLA group (5.3% vs 18.4%, p = 0.018). These patients also showed a higher mortality (28.1% vs 11%, p = 0.003). In multivariate analysis, E. coli isolation PLA adjusted remained as an independent factor of mortality (OR 2.6, 95%CI 1.04–6.56, p = 0.041).

Conclusions

E. coli liver abscess may preclude a worse outcome than other microbiological agents, including the development of septic shock and mortality. Aggressive management must be considered.

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Authors and Affiliations

  1. Department of Internal Medicine, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco La Ballena s/n, 35012, Las Palmas, Spain

    Jose Juan Ruiz-Hernández, Alicia Conde-Martel, Miriam Serrano-Fuentes, Marta Hernández-Meneses, Alejandro Merlán-Hermida & Alba Rodríguez-Pérez

  2. Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain

    Jose Juan Ruiz-Hernández, Alicia Conde-Martel & Joaquín Marchena-Gómez

  3. Department of General Surgery, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco La Ballena s/n, 35012, Las Palmas, Spain

    Joaquín Marchena-Gómez

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  1. Jose Juan Ruiz-Hernández
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Correspondence to Alicia Conde-Martel.

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Ruiz-Hernández, J.J., Conde-Martel, A., Serrano-Fuentes, M. et al. Pyogenic liver abscesses due to Escherichia coli are still related to worse outcomes. Ir J Med Sci 189, 155–161 (2020). https://doi.org/10.1007/s11845-019-02041-4

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