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Acute multiple sclerosis lesion pathology does not predict subsequent clinical course—a biopsy study

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Abstract

Background

Knowledge of the clinical outcome in tumefactive demyelination remains limited.

Aims

This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.

Methods

We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. A baseline, and at least one follow-up MRI scan was available in each instance (mean of 3 scans per patient), together with both the presenting and most recent clinical details including disability level and disease-modifying drugs.

Results

In 21 patients, white matter biopsies showed the following: macrophages with myelin debris, myelin-axonal dissociation, reactive astrocytes and occasional lymphocytes. During a mean follow-up time of 8 years (± 4.4), 17 patients developed MS, confirmed both clinically and on MRI, using the 2010 McDonald criteria: 11 relapsing remitting (RR) MS, four secondary progressive and two primary progressive MS. Four patients had a monophasic illness with lesion regression, without clinical or radiological evidence of any further disease activity on follow-up. The patients with progressive MS had significantly higher levels of physical disability than either the RRMS or monophasic patients.

Conclusion

Uniform white matter subacute demyelination is associated with a diverse clinical course ranging from a monophasic illness to progressive MS, suggesting that extraneous factors distinct from the basic pathology significantly influence the clinical course in MS.

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Authors and Affiliations

  1. Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin, Ireland

    Hugh Kearney, Tucker Price, Jane Cryan, Alan Beausang, Francesca M. Brett & Michael Farrell

  2. Department of Neuroradiology, Beaumont Hospital, Dublin, Ireland

    Seamus Looby

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  1. Hugh Kearney
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  2. Tucker Price
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Correspondence to Hugh Kearney.

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Kearney, H., Price, T., Cryan, J. et al. Acute multiple sclerosis lesion pathology does not predict subsequent clinical course—a biopsy study. Ir J Med Sci 188, 1427–1434 (2019). https://doi.org/10.1007/s11845-019-01983-z

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  • DOI: https://doi.org/10.1007/s11845-019-01983-z

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