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Recent advancements in bioreactions of cellular and cell-free systems: A study of bacterial cellulose as a model

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Abstract

Conventional approaches of regulating natural biochemical and biological processes are greatly hampered by the complexity of natural systems. Therefore, current biotechnological research is focused on improving biological systems and processes using advanced technologies such as genetic and metabolic engineering. These technologies, which employ principles of synthetic and systems biology, are greatly motivated by the diversity of living organisms to improve biological processes and allow the manipulation and reprogramming of target bioreactions and cellular systems. This review describes recent developments in cell biology, as well as genetic and metabolic engineering, and their role in enhancing biological processes. In particular, we illustrate recent advancements in genetic and metabolic engineering with respect to the production of bacterial cellulose (BC) using the model systems Gluconacetobacter xylinum and Gluconacetobacter hansenii. Besides, the cell-free enzyme system, representing the latest engineering strategies, has been comprehensively described. The content covered in the current review will lead readers to get an insight into developing novel metabolic pathways and engineering novel strains for enhanced production of BC and other bioproducts formation.

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Authors and Affiliations

  1. Department of Chemical Engineering, Kyungpook National University, Daegu, 41566, Korea

    Muhammad Wajid Ullah, Mazhar Ul Islam, Shaukat Khan & Joong Kon Park

  2. Department of Chemical Engineering, College of Engineering, Dhofar University, Salalah, 211, Oman

    Mazhar Ul Islam

  3. Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

    Muhammad Wajid Ullah

  4. Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan

    Nasrullah Shah

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  1. Muhammad Wajid Ullah
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  2. Mazhar Ul Islam
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  4. Nasrullah Shah
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Correspondence to Joong Kon Park.

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Joong Kon Park is a Professor in the Chemical Engineering Department at Kyungpook National University in Korea. He received his B.S. degree (Seoul National University, Korea), M.S. and Ph.D. degrees (KAIST, Korea), all in Chemical Engineering and was a postdoctoral fellow at the University of Michigan at Ann Arbor. His research interests include transport phenomena, and biochemical engineering, especially, bacterial cellulose nanocomposite.

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Ullah, M.W., Ul Islam, M., Khan, S. et al. Recent advancements in bioreactions of cellular and cell-free systems: A study of bacterial cellulose as a model. Korean J. Chem. Eng. 34, 1591–1599 (2017). https://doi.org/10.1007/s11814-017-0121-2

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