Skip to main content
SpringerLink
Log in

Morphological, thermal and drug release studies of poly (methacrylic acid)-based molecularly imprinted polymer nanoparticles immobilized in electrospun poly (ε-caprolactone) nanofibers as dexamethasone delivery system

  • Polymer, Industrial Chemistry
  • Published:
Korean Journal of Chemical Engineering Aims and scope Submit manuscript

Abstract

Electrospun poly (ε-caprolactone) (PCL) nanofibers containing molecularly imprinted polymer (MIP) nanoparticles based on methacrylic acid (MAA) were prepared for controlled release of dexamethasone (Dexa). First, the MIPs consisting of Dexa were synthesized via precipitation polymerization. Their recognition sites formation and thermal properties were investigated by FTIR and TGA tests, respectively. The results showed that by selecting a monomer: template (MAA:Dexa) molar ratio of 6 : 1, MIP nanoparticles were produced with imprinting factor of 1.80. The FESEM and TEM images showed the MIPs average diameter of 394±9.7 nm and appropriate immobilization of them in PCL nanofibers, respectively. Moreover, the cumulative release of Dexa from the MIP-loaded nanofibrous samples was studied by UV-vis spectrophotometry and revealed a suitable controlled release of the drug during four days. Afterward, Dexa release followed Higuchi model which indicated the main mechanism was governed by Fickian diffusion theory.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. H. Kim and D. C. Martin, Biomaterials, 27, 3031 (2006).

    Article  CAS  Google Scholar 

  2. I. S. Chronakis, A. Jakob, B. Hagstrom and L. Ye, Langmuir, 22, 8960 (2006).

    Article  CAS  Google Scholar 

  3. Q. Pan, Q. Xu, N. J. Boylan, N. W. Lamb, D. G. Emmert, J. C. Yang, L. Tang, T. Heflin, S. Alwadani and C. G. Eberhart, J. Control. Release, 201, 32 (2015).

    Article  CAS  Google Scholar 

  4. M. A. Kalam, Int. J. Biol. Macromol., 89, 559 (2016).

    Article  Google Scholar 

  5. N. M. Vacanti, H. Cheng, P. S. Hill, J. D. T. Guerreiro, T. T. Dang, M. L. Ma, S. Watson, N. S. Hwang, R. Langer and D. G. Anderson, Biomacromolecules, 13, 3031 (2012).

    Article  CAS  Google Scholar 

  6. J. R. Li, R. Fu, L. Li, G. Yang, S. Ding, Z. D. Zhong and S. B. Zhou, Pharm. Res.-Dordr., 31, 1632 (2014).

    Article  CAS  Google Scholar 

  7. W. M. Chen, D. W. Li, A. EI-Shanshory, M. El-Newehy, H. A. EI-Hamshary, S. S. Al-Deyab, C. L. He and X. M. Mo, Colloid Surf. B-Biointerfaces, 126, 561 (2015).

    Article  CAS  Google Scholar 

  8. Y. F. Li, M. Rubert, Y. Yu, F. Besenbacher and M. L. Chen, Rsc Adv., 5, 34166 (2015).

    Article  CAS  Google Scholar 

  9. C. Giovannoli, C. Passini, L. Anfossi, F. D. Nardo, G. Spano, V. Maurino and C. Baggiani, J. Sep. Sci., 38, 3661 (2015).

    Article  CAS  Google Scholar 

  10. K. Takimoto, E. Takano, Y. Kitayama and T. Takeuchi, Langmuir, 31, 4981 (2015).

    Article  CAS  Google Scholar 

  11. M. Pourfarzib, M. Shekarchi, H. Rastegar, B. Akbari-Adergani, A. Mehramizi and R. Dinarvand, J. Chromatogr. B, 974, 1 (2015).

    Article  CAS  Google Scholar 

  12. E. Asadi, S. Azodi-Deilami, M. Abdouss, D. Kordestani, A. Rahimi and S. Asadi, Korean J. Chem. Eng., 31, 1028 (2014).

    Article  CAS  Google Scholar 

  13. Y. F. Shi, H. L. Lv, X. F. Lu, Y. X. Huang, Y. Zhang and W. Xue, J. Mater. Chem., 22, 3889 (2012).

    Article  CAS  Google Scholar 

  14. Q. Gan, J. Zhu, Y. Yuan, H. Liu, J. Qian, Y. Li and C. Liu, J. Mater. Chem. B, 3, 2056 (2015).

    Article  CAS  Google Scholar 

  15. B. Sellergren and A. J. Hall, Molecularly imprinted polymers: From molecules to nanomaterials, John Wiley & Sons Ltd., New York (2012).

    Book  Google Scholar 

  16. L. Ye and K. Mosbach, Chem. Mat., 20, 859 (2008).

    Article  CAS  Google Scholar 

  17. M. Javanbakht, A. M. Attaran, M. H. Namjumanesh, M. Esfandyari-Manesh and B. Akbari-Adergani, J. Chromatogr. B, 878, 1700 (2010).

    Article  CAS  Google Scholar 

  18. G. Wulff, Chem. Rev., 102, 1 (2002).

    Article  CAS  Google Scholar 

  19. F. Mirata and M. Resmini, Molecularly imprinted polymers in biotechnology, Springer, Heidelberg (2015).

    Google Scholar 

  20. K. Haupt and K. Mosbach, Chem. Rev., 100, 2495 (2000).

    Article  CAS  Google Scholar 

  21. E. Mazzotta, A. Turco, I. Chianella, A. Guerreiro, S. A. Piletsky and C. Malitesta, Sensor. Actuat. B-Chem., 229, 174 (2016).

    Article  CAS  Google Scholar 

  22. E. Turiel, M. Díaz-Álvarez and A. Martín-Esteban, J. Chromatogr. A, 1432, 1 (2016).

    Article  CAS  Google Scholar 

  23. X. Su, X. Li, J. Li, M. Liu, F. Lei, X. Tan, P. Li and W. Luo, Food Chem., 171, 292 (2015).

    Article  CAS  Google Scholar 

  24. M. Kempe, K. Mosbach and L. Fischer, J. Mol. Recognit., 6, 25 (1993).

    Article  CAS  Google Scholar 

  25. J. Yin, G. Yang and Y. Chen, J. Chromatogr. A, 1090, 68 (2005).

    Article  CAS  Google Scholar 

  26. Y. Yang, X. Liu, M. Guo, S. Li, W. Liu and B. Xu, Colloid Surface A, 377, 379 (2011).

    Article  CAS  Google Scholar 

  27. E. Caro, R. M. Marcé, P. A. G. Cormack, D. C. Sherrington and F. Borrull, J. Chromatogr. A, 1047, 175 (2004).

    Article  CAS  Google Scholar 

  28. P. Zahedi, I. Rezaeian, S. H. Jafari and Z. Karami, Macromol. Res., 21, 649 (2013).

    Article  CAS  Google Scholar 

  29. L. T. H. Nguyen, S. Liao, C. K. Chan and S. Ramakrishna, J. Biomat. Sci.-Polym. E., 23, 1771 (2012).

    CAS  Google Scholar 

  30. M. Esfandyari-Manesh, M. Javanbakht, F. Atyabi, A. Mohammadi, S. Mohammadi, B. Akbari-Adergani and R. Dinarvand, Mat. Sci. Eng. C-Mater., 31, 1692 (2011).

    Article  CAS  Google Scholar 

  31. M. Abdouss, E. Asadi, S. Azodi-Deilami, N. Beik-mohammadi and S. A. Aslanzadeh, J. Mater. Sci.-Mater. M., 22, 2273 (2011).

    Article  CAS  Google Scholar 

  32. H. Hiratani, A. Fujiwara, Y. Tamiya, Y. Mizutani and C. Alvarez-Lorenzo, Biomaterials, 26, 1293 (2005).

    Article  CAS  Google Scholar 

  33. B. Malaekeh-Nikouei, F. A. Ghaeni, V. S. Motamedshariaty and S. A. Mohajeri, J. Appl. Polym. Sci., 126, 387 (2012).

    Article  CAS  Google Scholar 

  34. X. F. Lu, Y. F. Shi, H. L. Lv, Y. Y. Fu, D. Ma and W. Xue, J. Mater. Sci.-Mater. M., 25, 1461 (2014).

    Article  CAS  Google Scholar 

  35. G. Cirillo, M. Curcio, O. I. Parisi, F. Puoci, F. Iemma, U. G. Spizzirri, D. Restuccia and N. Picci, Food Chem., 125, 1058 (2011).

    Article  CAS  Google Scholar 

  36. A. Mohebali, M. Abdouss, S. Mazinani and P. Zahedi, Polym. Adv. Technol., 27, 1164 (2016).

    Article  CAS  Google Scholar 

  37. L. Zhang, Y. Guo, W. H. Chi, H. G. Shi, H. Q. Ren and T. Y. Guo, Chin. J. Polym. Sci., 32, 1469 (2014).

    Article  CAS  Google Scholar 

  38. T. Hickey, D. Kreutzer, D. J. Burgess and F. Moussy, J. Biomed. Mater. Res., 61, 180 (2002).

    Article  CAS  Google Scholar 

  39. C. Miura, H. Matsunaga and J. Haginaka, J. Pharmaceut. Biomed., 127, 32 (2016).

    Article  CAS  Google Scholar 

  40. Y. Nakamura, H. Matsunaga and J. Haginaka, J. Sep. Sci., 39, 1542 (2016).

    Article  CAS  Google Scholar 

  41. M. Zamani, M. Morshed, J. Varshosaz and M. Jannesari, Eur. J. Pharm. Biopharm., 75, 179 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P. O. Box, 11155-4563, Tehran, Iran

    Payam Zahedi, Mahshid Fallah-Darrehchi, Shima Ahmadi Nadoushan, Robabeh Aeinehvand, Lida Bagheri & Mohammad Najafi

Authors
  1. Payam Zahedi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mahshid Fallah-Darrehchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shima Ahmadi Nadoushan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robabeh Aeinehvand
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lida Bagheri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mohammad Najafi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Payam Zahedi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zahedi, P., Fallah-Darrehchi, M., Nadoushan, S.A. et al. Morphological, thermal and drug release studies of poly (methacrylic acid)-based molecularly imprinted polymer nanoparticles immobilized in electrospun poly (ε-caprolactone) nanofibers as dexamethasone delivery system. Korean J. Chem. Eng. 34, 2110–2118 (2017). https://doi.org/10.1007/s11814-017-0078-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11814-017-0078-1

Keywords

Search

Navigation