Abstract
There is accumulating evidence that showing oxidative stress plays a critical role in the progression of diabetes. It was reported that geraniol, as monoterpenoid alcohol, has antioxidant properties. This study aimed to investigate the effect of geraniol on serum lipid parameters and antioxidant defense systems in the pancreas, liver, and heart tissues of alloxan-induced diabetic rats. Forty albino wistar rats were randomly divided into five groups, including (I) control group, (II) diabetic group, (III) the diabetic group treated with glibenclamide, (IV) the diabetic group treated with 200 mg/kg geraniol, and (V) the diabetic group receiving the geraniol solvent for four weeks. At the end of treatment, serum glucose level, lipid profile (TG, TC, LDL, and HDL), liver aminotransferases (ALT, AST), and ALP activities in different groups were measured. Furthermore, malondialdehyde (MDA) content, as a lipid peroxidation marker, the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD) enzymes were assessed in pancreas, liver, and heart tissues of different groups. The result indicated that treatment with geraniol decreased fasting blood glucose, HbA1c, triglyceride, total cholesterol, and LDL-cholesterol, whereas the blood high-density lipoprotein -cholesterol level was elevated. In addition, treatment of diabetic rats with geraniol increased the activity of GPx and SOD antioxidant enzymes and decreased the MDA content as a marker of lipid peroxidation in the pancreas, liver, and heart tissues as compared to the diabetic rats. Due to the high potential of geraniol in lowering blood sugar and oxidative parameters in the various tissues of diabetic rats, the antioxidant property of geraniol is the most likely mechanism for its hypoglycemic effect.
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Abbreviations
- DM:
-
Diabetes mellitus
- ROS:
-
Reactive oxygen species
- RNS:
-
Reactive nitrogen species
- GSH:
-
Reduced glutathione
- TBA:
-
Thiobarbituric acid
- TCA:
-
Trichloroacetic acid
- TC:
-
Total cholesterol
- TG:
-
Triglyceride
- LDL:
-
Low density lipoprotein
- HDL:
-
High density lipoproteins
- AST:
-
Aspartate aminotransferase
- ALT:
-
Alanine aminotransferase
- ALP:
-
Alkaline phosphatase
- MDA:
-
Malondialdehyde
- HbA1c:
-
Glycated hemoglobin
- GPx:
-
Glutathione peroxidase
- SOD:
-
Superoxide dismutase
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The authors appreciate the financial support of Lorestan University for this investigation.
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Eskandari, N., Bahramikia, S., Mohammadi, A. et al. Geraniol ameliorated serum lipid profile and improved antioxidant defense system in pancreas, liver and heart tissues of alloxan-induced diabetic rats. Biologia 77, 241–248 (2022). https://doi.org/10.1007/s11756-021-00925-4
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DOI: https://doi.org/10.1007/s11756-021-00925-4