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An instrumental variable approach under dependent censoring

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Abstract

This paper considers the problem of inferring the causal effect of a variable Z on a dependently censored survival time T. We allow for unobserved confounding variables, such that the error term of the regression model for T is dependent on the confounded variable Z. Moreover, T is subject to dependent censoring. This means that T is right censored by a censoring time C, which is dependent on T (even after conditioning out the effects of the measured covariates). A control function approach, relying on an instrumental variable, is leveraged to tackle the confounding issue. Further, it is assumed that T and C follow a joint regression model with bivariate Gaussian error terms and an unspecified covariance matrix, such that the dependent censoring can be handled in a flexible manner. Conditions under which the model is identifiable are given, a two-step estimation procedure is proposed, and it is shown that the resulting estimator is consistent and asymptotically normal. Simulations are used to confirm the validity and finite-sample performance of the estimation procedure. Finally, the proposed method is used to estimate the causal effect of job training programs on unemployment duration.

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References

  • Abadie A, Angrist J, Imbens G (2002) Instrumental variables estimates of the effect of subsidized training on the quantiles of trainee earnings. Econometrica 70(1):91–117

    Article  MathSciNet  Google Scholar 

  • Aldrich JH, Nelson FD (1991) Linear probability, logit, and probit models, 10th edn. Quantitative applications in the social sciences 45, Sage, Newbury Park

  • Angrist JD, Imbens GW, Rubin DB (1996) Identification of causal effects using instrumental variables. J Am Stat Assoc 91(434):444–455

    Article  Google Scholar 

  • Beyhum J, Florens JP, Van Keilegom I (2023) A nonparametric instrumental approach to confounding in competing risks models. Lifetime Data Anal 1–26

  • Beyhum J, Florens JP, Van Keilegom I (2022) Nonparametric instrumental regression with right censored duration outcomes. J Business Econ Stat 40(3):1034–1045

    Article  MathSciNet  Google Scholar 

  • Beyhum J, Tedesco L, Van Keilegom I (2023) Instrumental variable quantile regression under random right censoring. Economet J utad015

  • Bijwaard GE, Ridder G (2005) Correcting for selective compliance in a re-employment bonus experiment. J Econ 125(1):77–111

    MathSciNet  Google Scholar 

  • Blanco G, Chen X, Flores CA et al (2020) Bounds on average and quantile treatment effects on duration outcomes under censoring, selection, and noncompliance. J Business Econ Stat 38(4):901–920

    Article  MathSciNet  Google Scholar 

  • Bloom HS, Orr LL, Bell SH et al (1997) The benefits and costs of jtpa title ii-a programs: key findings from the national job training partnership act study. J Hum Resour 32(3):549–576

    Article  Google Scholar 

  • Braekers R, Veraverbeke N (2005) A copula-graphic estimator for the conditional survival function under dependent censoring. Can J Stat 33(3):429–447

    Article  MathSciNet  Google Scholar 

  • Centorrino S, Florens JP (2021) Nonparametric estimation of accelerated failure-time models with unobservable confounders and random censoring. Electron J Stat 15(2):5333–5379

    Article  MathSciNet  Google Scholar 

  • Chernozhukov V, Fernández-Val I, Kowalski AE (2015) Quantile regression with censoring and endogeneity. J Econ 186(1):201–221

    Article  MathSciNet  Google Scholar 

  • Czado C, Van Keilegom I (2023) Dependent censoring based on parametric copulas. Biometrika 110(3):721–738

    Article  MathSciNet  Google Scholar 

  • Deresa NW, Van Keilegom I (2020) Flexible parametric model for survival data subject to dependent censoring. Biom J 62(1):136–156

    Article  MathSciNet  Google Scholar 

  • Deresa NW, Van Keilegom I (2020) A multivariate normal regression model for survival data subject to different types of dependent censoring. Comput Stat Data Anal 144(106):879

    MathSciNet  Google Scholar 

  • Deresa NW, Van Keilegom I (2020) On semiparametric modelling, estimation and inference for survival data subject to dependent censoring. Biometrika 108(4):965–979

    Article  MathSciNet  Google Scholar 

  • Deresa NW, Van Keilegom I (2023) Copula based Cox proportional hazards models for dependent censoring. J Am Stat Assoc (just-accepted):1–23

  • Emura T, Chen YH (2018) Analysis of survival data with dependent censoring: copula-Based Approaches. Springer

  • Escanciano JC, Jacho-Chávez D, Lewbel A (2016) Identification and estimation of semiparametric two-step models. Quant Econ 7(2):561–589

    Article  MathSciNet  Google Scholar 

  • Frandsen BR (2015) Treatment effects with censoring and endogeneity. J Am Stat Assoc 110(512):1745–1752

    Article  MathSciNet  Google Scholar 

  • Heckman JJ (1979) Sample selection bias as a specification error. Econometrica 47(1):153–161

    Article  MathSciNet  Google Scholar 

  • Huang X, Zhang N (2008) Regression survival analysis with an assumed copula for dependent censoring: a sensitivity analysis approach. Biometrics 64(4):1090–1099

    Article  MathSciNet  Google Scholar 

  • Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53(282):457–481

    Article  MathSciNet  Google Scholar 

  • Khan S, Tamer E (2009) Inference on endogenously censored regression models using conditional moment inequalities. J Econ 152(2):104–119

    Article  MathSciNet  Google Scholar 

  • Lee S (2007) Endogeneity in quantile regression models: a control function approach. J Econ 141(2):1131–1158

    Article  MathSciNet  Google Scholar 

  • Li J, Fine J, Brookhart A (2015) Instrumental variable additive hazards models. Biometrics 71(1):122–130

    Article  MathSciNet  Google Scholar 

  • Manski CF (1988) Identification of binary response models. J Am Stat Assoc 83(403):729–738

    Article  MathSciNet  Google Scholar 

  • Martinussen T, Vansteelandt S (2020) Instrumental variables estimation with competing risk data. Biostatistics 21(1):158–171

    Article  MathSciNet  Google Scholar 

  • Navarro S (2010) Control functions. Palgrave Macmillan UK, London, pp 20–28

    Google Scholar 

  • Newey WK, McFadden D (1994) Large sample estimation and hypothesis testing. Handb Econ 4:2111–2245

    MathSciNet  Google Scholar 

  • Oxley L, McAleer M (1993) Econometric issues in macroeconomic models with generated regressors. J Econ Surv 7(1):1–40

    Article  Google Scholar 

  • Pagan A (1984) Econometric issues in the analysis of regressions with generated regressors. Int Econ Rev 25(1):221–247

    Article  MathSciNet  Google Scholar 

  • Richardson A, Hudgens MG, Fine JP et al (2017) Nonparametric binary instrumental variable analysis of competing risks data. Biostatistics 18(1):48–61

    Article  MathSciNet  Google Scholar 

  • Richardson LF (1911) Ix. The approximate arithmetical solution by finite differences of physical problems involving differential equations, with an application to the stresses in a masonry dam. Philos Transact Royal Soc London Ser A, Contain Papers Math Phys Character 210(459–470):307–357

    Google Scholar 

  • Rivest LP, Wells MT (2001) A martingale approach to the copula-graphic estimator for the survival function under dependent censoring. J Multivar Anal 79(1):138–155

    Article  MathSciNet  Google Scholar 

  • Robins JM, Finkelstein DM (2000) Correcting for noncompliance and dependent censoring in an aids clinical trial with inverse probability of censoring weighted (ipcw) log-rank tests. Biometrics 56(3):779–788

    Article  Google Scholar 

  • Sant’Anna PHC (2016) Program evaluation with right-censored data. arXiv preprint arXiv:1604.02642

  • Sperlich S (2009) A note on non-parametric estimation with predicted variables. Economet J 12(2):382–395

    Article  MathSciNet  Google Scholar 

  • Staplin N, Kimber A, Collett D et al (2015) Dependent censoring in piecewise exponential survival models. Stat Methods Med Res 24(3):325–341

    Article  MathSciNet  Google Scholar 

  • Sujica A, Van Keilegom I (2018) The copula-graphic estimator in censored nonparametric location-scale regression models. Econom Stat 7:89–114

    MathSciNet  Google Scholar 

  • Tchetgen Tchetgen EJ, Walter S, Vansteelandt S et al (2015) Instrumental variable estimation in a survival context. Epidemiology 26(3):402–410

    Article  Google Scholar 

  • Tsiatis A (1975) A nonidentifiability aspect of the problem of competing risks. Proc Natl Acad Sci–PNAS 72(1):20–22

    Article  MathSciNet  Google Scholar 

  • Wooldridge JM (2010) Econometric Analysis of Cross Section and Panel Data. MIT press

  • Wooldridge JM (2015) Control function methods in applied econometrics. J Hum Resour 50(2):420–445

    Article  Google Scholar 

  • Zheng C, Dai R, Hari PN et al (2017) Instrumental variable with competing risk model. Stat Med 36(8):1240–1255

    Article  MathSciNet  Google Scholar 

  • Zheng M, Klein JP (1995) Estimates of marginal survival for dependent competing risks based on an assumed copula. Biometrika 82(1):127–138

    Article  MathSciNet  Google Scholar 

Download references

Acknowledgements

Financial support from the European Research Council (2016-2022, Horizon 2020 / ERC grant agreement No. 694409) is gratefully acknowledged. The authors are grateful for the valuable suggestions and feedback from the reviewers. Moreover, the authors would like to thank Sara Rutten and Ilias Willems for their useful comments and remarks.

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Correspondence to Gilles Crommen.

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Crommen, G., Beyhum, J. & Van Keilegom, I. An instrumental variable approach under dependent censoring. TEST (2023). https://doi.org/10.1007/s11749-023-00903-9

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