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Treatment of bronchial fistula after extraplural pneumonectomy using flexible bronchoscopy with the administration of OK432, fibroblast growth factor basic and fibrin glue sealant

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Abstract

Treatment options for bronchial fistula (BF) after pneumonectomy are often limited and carry significant morbidity and mortality. The patient underwent right extrapleural pneumonectomy for malignant pleural mesothelioma had BF without macroscopic fistula found by bronchography. We treated this minor BF using bronchoscopy with the administration of OK-432, fibroblast growth factor basic, and fibrin glue sealant. Two weeks after this treatment, we confirmed the improvement of the fistula by bronchography. Bronchoscopic therapy for BF was useful for a small, early fistula without infection.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Nobuyuki Kondo, Masaki Hashimoto, Teruhisa Takuwa, Seiji Matsumoto, Yoshitomo Okumura & Seiki Hasegawa

  2. Department of Thoracic Surgery, Itami Municipal Hospital, Hyogo, Japan

    Yoshitomo Okumura

Authors
  1. Nobuyuki Kondo
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  2. Masaki Hashimoto
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  3. Teruhisa Takuwa
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  4. Seiji Matsumoto
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  5. Yoshitomo Okumura
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  6. Seiki Hasegawa
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Correspondence to Nobuyuki Kondo.

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The authors have no conflict of interest.

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The facility’s ethics review board accepted the application for unapproved usage of insured drugs in the form of a post-process under control number 202005-217.

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Informed consent was obtained from the patient.

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Kondo, N., Hashimoto, M., Takuwa, T. et al. Treatment of bronchial fistula after extraplural pneumonectomy using flexible bronchoscopy with the administration of OK432, fibroblast growth factor basic and fibrin glue sealant. Gen Thorac Cardiovasc Surg 68, 1562–1564 (2020). https://doi.org/10.1007/s11748-020-01349-8

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  • DOI: https://doi.org/10.1007/s11748-020-01349-8

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