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Chest wall/parietal pleural invasions worsen prognosis in T4 non-small cell lung cancer patients after resection

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Abstract

Objectives

Appropriate selection for surgery is particularly important in T4 non-small cell lung cancer patients. In clinical settings, patients those who are positive for T4 criteria occasionally are also positive for T3 factors which are independently defined from original T4 or even have multiple T4 factors. Significance of these factors on prognosis is still unknown.

Methods

We retrospectively reviewed clinicopathorogical data of 113 patients with T4 non-small cell lung cancer those who underwent surgery between 1990 and 2015 in Tohoku University Hospital. Significance on prognosis of single or multiple T4 factors and with or without independent T3 factors were statistically analyzed.

Results

No significant difference was seen in the 5-year survival rate between patients with single (35.6%) and multiple (31.4%) T4 factors (P = 0.94), but the rate was significantly lower when patients also had independent T3 factors (19.6%) compared with when they did not (42.5%) (P = 0.011). The 5-year survival rate was particularly lower among patients with invasion of the chest wall or parietal pleura (8.1%) than in those without (40.6%) (P = 0.0052).

Conclusions

Invasion of the chest wall or parietal pleura is poor prognostic factors in T4 non-small cell lung cancer patients.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, 980-8575, Japan

    Hiroshi Yabuki, Akira Sakurada, Shunsuke Eba, Fumihiko Hoshi, Hisashi Oishi, Yasushi Matsuda, Tetsu Sado, Masafumi Noda & Yoshinori Okada

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  1. Hiroshi Yabuki
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  2. Akira Sakurada
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  3. Shunsuke Eba
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  4. Fumihiko Hoshi
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  5. Hisashi Oishi
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  6. Yasushi Matsuda
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  7. Tetsu Sado
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  8. Masafumi Noda
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  9. Yoshinori Okada
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Correspondence to Akira Sakurada.

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Yabuki, H., Sakurada, A., Eba, S. et al. Chest wall/parietal pleural invasions worsen prognosis in T4 non-small cell lung cancer patients after resection. Gen Thorac Cardiovasc Surg 67, 788–793 (2019). https://doi.org/10.1007/s11748-019-01093-8

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  • DOI: https://doi.org/10.1007/s11748-019-01093-8

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