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An entire clinical course of mediastinal myxofibrosarcoma treated by surgery and radiation

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Abstract

A woman in her 70s with an 8.6-cm tumor in the anterior mediastinum underwent tumor excision by median sternotomy, which combined resection of the fifth and sixth ribs. The pathological diagnosis was myxofibrosarcoma, and pathologically curative resection was accomplished. Local recurrence was detected at 10, 19, 23 and 28 months after the initial surgery. After repeated surgical resection, radiation therapy for the fourth unresectable recurrence resulted in failure. She died 34 months after the initial surgery. There have been 3 case reports of mediastinal myxofibrosarcoma. With regard to prognosis, control over local recurrence by surgical resection might be essential to achieve a long survival. However, the clinical course of mediastinal myxofibrosarcoma has not been reported in detail. This is the first description on the entire clinical course of mediastinal myxofibrosarcoma.

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Authors and Affiliations

  1. Department of General Thoracic Surgery, National Hospital Organization, Kanagawa National Hospital, 666-1 Ochiai, Hadano, Kanagawa, 257-8585, Japan

    Yasoo Sugiura, Hiroyuki Fujimoto, Toshinori Hashizume & Etsuo Nemoto

  2. Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan

    Go Ogura

Authors
  1. Yasoo Sugiura
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  2. Hiroyuki Fujimoto
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  3. Toshinori Hashizume
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  4. Go Ogura
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  5. Etsuo Nemoto
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Corresponding author

Correspondence to Yasoo Sugiura.

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The author and co-authors have no potential conflict of interests to disclose.

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Sugiura, Y., Fujimoto, H., Hashizume, T. et al. An entire clinical course of mediastinal myxofibrosarcoma treated by surgery and radiation. Gen Thorac Cardiovasc Surg 66, 748–752 (2018). https://doi.org/10.1007/s11748-018-0935-9

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  • DOI: https://doi.org/10.1007/s11748-018-0935-9

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