Abstract
Hepatitis C virus (HCV) infection is now considered a systemic disease due to the occurrence of extra-hepatic manifestations. Among these, the renal involvement is frequent. HCV infection, in fact, is strongly associated with proteinuria and chronic kidney disease (CKD) and negatively affects the prognosis of renal patients. In the last few years, availability of more specific and effective drugs against HCV has dramatically changed the clinical course of this disease. These drugs may provide further advantages in the CKD population as a whole by reducing progression of renal disease, mortality rate and by increasing the survival of graft in renal transplant recipients. The strict pathogenetic and prognostic link between HCV infection and CKD requires an ongoing relationship among the healthcare professionals involved in the treatment of both HCV infection and CKD. Therefore, Scientific Societies involved in the care of this high-risk population in Italy have organized a joint expert panel. The aim of the panel is to produce a position statement that can be used in daily clinical practice for the management of HCV infected patients across the whole spectrum of renal disease, from the conservative phase to renal replacement treatments (dialysis and transplantation). Sharing specific evidence-based expertise of different professional healthcare is the first step to obtain a common ground of knowledge on which to instate a model for multidisciplinary management of this high-risk population. Statements cover seven areas including epidemiology of CKD, HCV-induced glomerular damage, HCV-related renal risk, staging of liver disease in patients with CKD, prevention of transmission of HCV in hemodialysis units, treatment of HCV infection and management of HCV in kidney transplantation.
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Roberto Minutolo has received speaker honoraria/consultant fees from Abbvie. Alessio Aghemo has received speaker honoraria/ consultant fees/travel grants from Abbvie, Gilead, MSD, Janssen, BMS, Alfasigma and research grants from Gilead and Abbvie. Antonio Chirianni has received speaker honoraria/ consultant fees from Gilead, AbbVie, BMS, MSD. Fabrizio Fabrizi has received consultant fees from Abbvie and MSD. Loreto Gesualdo has no conflict of interest to declare. Edoardo G. Giannini has received speaker honoraria/consultant fees from AbbVie, Bayer, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Janssen Cilag, MSD, and Novartis. Paolo Maggi has received honoraria/ consultant fees/travel grants from Abbvie, Gilead, MSD, Janssen, BMS, ViiV. Vincenzo Montinaro has received speaker honoraria/travel grants from Abbvie, Janssen, ViiV Healthcare, Alexion, Shire, CSL Behring. Ernesto Paoletti has received consultant fees from Abbvie, Novartis, Vifor Fresenius Pharma. Marcello Persico has received speaker honoraria from Abbvie, BMS, Gilead, MSD. Francesco Perticone has no conflict of interest to declare. Salvatore Petta has received speaker honoraria/ consultant fees/travel grants from Abbvie, BMS, Gilead, Intercept, MSD, Polifarma, Tobira. Massimo Puoti has received speaker honoraria from Abbvie Gilead sciences MSD and research grants from Gilead sciences. Giovanni Raimondo has received speaker honoraria/consultant fees from Abbvie, BMS, Gilead Science, Janssen Cilag, MSD, Bayer, and research grants from Abbvie, BMS, Gilead Science. Maria Rendina has received speaker honoraria/consultant fees/travel grants from Abbvie, Gilead, MSD, BMS, Kedrion, Biotest, Griffons, Astellas, Novartis. Anna Linda Zignego has received speaker honoraria/consulting fees from Abbvie, Gilead, MSD, Janssen, BMS.
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This article is co-published in the journals Journal of Nephrology https://doi.org/10.1007/s40620-018-0523-1, Internal and Emergency Medicine https://doi.org/10.1007/s11739-018-1940-9, Infection https://doi.org/10.1007/s15010-018-1209-2 and Digestive and Liver Disease https://doi.org/10.1016/j.dld.2018.08.022.
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Minutolo, R., Aghemo, A., Chirianni, A. et al. Management of hepatitis C virus infection in patients with chronic kidney disease: position statement of the joint committee of Italian association for the study of the liver (AISF), Italian society of internal medicine (SIMI), Italian society of infectious and tropical disease (SIMIT) and Italian society of nephrology (SIN). Intern Emerg Med 13, 1139–1166 (2018). https://doi.org/10.1007/s11739-018-1940-9
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DOI: https://doi.org/10.1007/s11739-018-1940-9