Efficacy and effect on related brain-gut peptides of acupoint sticking therapy for functional dyspepsia

Abstract

Objective

To observe the efficacy of acupoint sticking with Jianpi Tongjing Zhitong ointment in the treatment of functional dyspepsia due to liver-qi stagnation and spleen deficiency and its effect on serum 5-hydroxytryptamine (5-HT) and ghrelin contents.

Methods

One hundred patients with functional dyspepsia due to liver-qi stagnation and spleen deficiency were divided into a treatment group and a control group by the random number table method, with 50 cases in each group. The treatment group received acupoint sticking with Jianpi Tongjing Zhitong ointment and the control group was treated with mosapride citrate orally. Patients were treated for 4 weeks as a course. The therapeutic efficacy was compared after one-course treatment and the differences in gastric emptying rate, and serum 5-HT and ghrelin contents between groups were compared before and after treatment.

Results

The total effective rate was 79.6% in the control group and 89.4% in the treatment group, showing significantly different between groups (P<0.05). After treatment, the gastric emptying rate and serum ghrelin content of the two groups increased significantly, and the serum 5-HT content decreased significantly, the intra-group differences were significant (all P<0.01). After treatment, the gastric emptying rate and serum ghrelin content were significantly higher in the treatment group than those in the control group, while the serum 5-HT was significant lower in the treatment group, the inter-group differences were significant (all P<0.05). A negative correlation (r=−0.59) was observed between serum 5-HT content and gastric emptying rate, and a positive correlation (r=0.64) was observed between serum ghrelin content and gastric emptying rate, showing statistical significance (all P<0.01).

Conclusion

Acupoint sticking with Jianpi Tongjing Zhitong ointment has a remarkable clinical efficacy in treating patients with functional dyspepsia due to liver-qi stagnation and spleen deficiency and is able to influence the secretion of serum 5-HT and ghrelin. Improving the gastrointestinal motility through the regulation of related brain-gut peptides is suggested as an underlying mechanism for this therapy.

摘要

目的

观察健脾通经止痛膏穴位贴敷治疗肝郁脾虚型功能性消化不良的临床疗效及对血清中5-羟色胺 (5-HT)和胃促生长素(Ghrelin)含量的影响。

方法

将100例肝郁脾虚型功能性消化不良患者按随机数字表法分为治疗 组和对照组, 每组50例。治疗组予健脾通经止痛膏穴位贴敷治疗, 对照组予枸橼酸莫沙必利片口服治疗。4周为1个 疗程, 1个疗程后比较两组的临床疗效及治疗前后患者胃排空率、血清5-HT和Ghrelin的含量。

结果

对照组总有效 率为79.6%, 治疗组为89.4%, 两组比较差异有统计学意义(P<0.05)。两组治疗后胃排空率和血清Ghrelin含量显著升 高, 血清5-HT含量明显降低, 组内差异均有统计学意义(均P<0.01)。治疗组胃排空率和血清Ghrelin含量明显高于对 照组, 血清5-HT含量明显低于对照组, 组间差异均有统计学意义(均P<0.05)。血清5-HT水平与胃排空率呈负相关 (r=−0.59), 血清Ghrelin水平与胃排空率呈正相关(r=0.64), 具有统计学意义(均P<0.01)。

结论

健脾通经止痛膏穴位贴 敷治疗肝郁脾虚型功能性消化不良临床疗效显著, 并能影响患者血清5-HT和Ghrelin的分泌; 通过调节脑肠肽的分泌, 从而影响胃肠道运动,可能是其治疗功能性消化不良的潜在作用机制。