Effect of mild moxibustion on cancer-related fatigue, serum ghrelin and adiponectin in patients undergoing chemotherapy after colorectal cancer surgery

Abstract

Objective

To observe the effect of mild moxibustion on cancer-related fatigue, serum ghrelin and adiponectin in patients undergoing chemotherapy after colorectal cancer surgery.

Methods

Seventy patients were divided into a control group and an observation group according to the random number table method, with 35 cases in each group. Patients in both groups were treated with conventional FOLFOX4 chemotherapy regimen. Patients in the control group also received routine treatments such as symptomatic treatment of complications, health education, nutritional support, and exercise intervention. Patients in the observation group received mild moxibustion on the basis of interventions used in the control group. The Piper fatigue scale-revision (PFS-R), Karnofsky performance status (KPS) and spleen and kidney yang deficiency syndrome were scored, and serum ghrelin and adiponectin levels were measured before and after treatment.

Results

After treatment, total score of PFS-R in the control group did not change significantly (P>0.05), while in the observation group it was significantly reduced (P<0.05) and lower than that in the control group (P<0.05); KPS scores in both groups were increased (both P<0.05), and it was significantly higher in the observation group than in the control group (P<0.05); total score of spleen and kidney yang deficiency syndrome in the control group did not change significantly (P>0.05), while it was significantly reduced in the observation group (P<0.05) and lower than that in the control group (P<0.05); serum ghrelin and adiponectin levels in the control group had no significant changes (both P>0.05), but the levels were significantly increased in the observation group (both P<0.05) and higher than those in the control group (both P<0.05).

Conclusion

Based on the routine treatments, mild moxibustion can relieve fatigue, improve quality of life, and improve the symptoms of spleen and kidney yang deficiency in patients undergoing chemotherapy after colorectal cancer surgery, which may be related to the regulation of serum ghrelin and adiponectin levels.

【摘要】

目的: 观察温和灸对大肠癌术后化疗患者癌因性疲乏, 血清胃促生长素及脂联素的影响。方法: 将70例患者根据随机数字表法分为对照组和观察组, 每组35例。两组患者均均采用常规FOLFOX4化疗方案。对照组同时接受并发症对症治疗, 健康教育, 营养支持, 运动干预等常规治疗。观察组在对照组干预基础上加用温和灸。治疗前后进行Piper疲乏修订量表(PFS-R), 卡氏体力状态(KPS)及脾肾阳虚证候评分, 测定血清胃促生长素及脂联素水平。结果: 治疗后, 对照组PFS-R总分无明显改变(P>0.05), 观察组PFS-R总分明显降低(P<0.05), 且低于对照组(P<0.05); 两组KPS评分均升高(均P<0.05), 观察组KPS评分明显高于对照组(P<0.05); 对照组脾肾阳虚证候总分无明显变化(P>0.05), 观察组脾肾阳虚证候总分明显降低(P<0.05), 且低于对照组(P<0.05); 对照组血清胃促生长素和脂联素水平均无明显变化(均P>0.05), 观察组血清胃促生长素和脂联素水平均明显升高(均P<0.05), 且高于对照组(均P<0.05)。结论: 常规治疗基础上加用温和灸可缓解结肠直肠肿瘤术后化疗患者的疲乏程度, 提高生存质量, 改善脾肾阳虚症状, 这可能与其调节血清胃促生长素和脂联素水平相关。